(47 nodes) Regulation of platelet activation network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Serpine2	Glia-derived nexin. (397 aa)
	Syk	Tyrosine-protein kinase SYK. (629 aa)
	Prkcd	Protein kinase C delta type isoform X1. (700 aa)
	Ctsg	Cathepsin G. (259 aa)
	Blk	Tyrosine-protein kinase Blk. (499 aa)
	Dmtn	Dematin actin binding protein. (383 aa)
	Pdgfb	Platelet-derived growth factor subunit B. (242 aa)
	Abat	4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase. (500 aa)
	Gp1bb	Platelet glycoprotein Ib beta chain. (214 aa)
	Hrg	Histidine-rich glycoprotein. (536 aa)
	Gp5	Platelet glycoprotein V. (567 aa)
	Emilin2	Elastin microfibril interfacer 2. (1031 aa)
	Adrb2	Adrenergic receptor beta-2. (418 aa)
	Gnaq	Guanine nucleotide-binding protein G(q) subunit alpha. (359 aa)
	Jak2	Tyrosine-protein kinase JAK2. (1132 aa)
	Prkg1	CGMP-dependent protein kinase 1 isoform X1. (686 aa)
	Prkcq	Protein kinase C theta type isoform X1. (707 aa)
	Ptprj	Receptor-type tyrosine-protein phosphatase eta. (1352 aa)
	Fgg	Fibrinogen gamma chain isoform X1. (443 aa)
	Il6ra	Interleukin-6 receptor subunit alpha isoform X1. (460 aa)
	Ptger3	Prostaglandin E2 receptor EP3 subtype isoform X1. (366 aa)
	Tlr4	Toll-like receptor 4. (835 aa)
	Fundc2	FUN14 domain-containing protein 2. (151 aa)
	Flna	Filamin-A isoform X1. (2647 aa)
	Ubash3b	Ubiquitin-associated and SH3 domain-containing protein B isoform X1. (638 aa)
	Adamts18	A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1. (1219 aa)
	Vps33b	Vacuolar protein sorting-associated protein 33B isoform X1. (617 aa)
	Apoe	Apolipoprotein E. (312 aa)
	Mmrn1	Multimerin-1 isoform X1. (1212 aa)
	Pdgfa	Platelet-derived growth factor subunit A isoform X1. (211 aa)
	Sh2b3	SH2B adapter protein 3 isoform X1. (548 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha isoform X1. (1089 aa)
	Tec	LOW QUALITY PROTEIN: tyrosine-protein kinase Tec. (632 aa)
	Txk	Tyrosine-protein kinase TXK isoform X1. (527 aa)
	Emilin1	EMILIN-1. (1023 aa)
	Il6	Interleukin 6. (211 aa)
	Pdpn	Podoplanin isoform X1. (172 aa)
	Pla2g4a	Cytosolic phospholipase A2 isoform X1. (748 aa)
	Selp	Selectin, platelet. (768 aa)
	Fcer1g	High affinity immunoglobulin epsilon receptor subunit gamma. (92 aa)
	F11r	Junctional adhesion molecule 1. (300 aa)
	Plek	Pleckstrin isoform X1. (350 aa)
	Alox12	Arachidonate 12-lipoxygenase, 12S-type isoform X1. (663 aa)
	Gp1ba	Platelet glycoprotein Ib alpha chain. (718 aa)
	Prkca	Classical protein kinase C alpha type. (672 aa)
	C1qtnf1	Complement C1q tumor necrosis factor-related protein 1/6/8. (281 aa)
	Mfsd2b	Major facilitator superfamily domain-containing protein 2B. (493 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adrb2	Gnaq	MGP_CAROLIEiJ_P0046887	MGP_CAROLIEiJ_P0048330	Adrenergic receptor beta-2.	Guanine nucleotide-binding protein G(q) subunit alpha.	0.585
Adrb2	Il6	MGP_CAROLIEiJ_P0046887	MGP_CAROLIEiJ_P0067110	Adrenergic receptor beta-2.	Interleukin 6.	0.410
Alox12	Pla2g4a	MGP_CAROLIEiJ_P0027807	MGP_CAROLIEiJ_P0020264	Arachidonate 12-lipoxygenase, 12S-type isoform X1.	Cytosolic phospholipase A2 isoform X1.	0.915
Apoe	Il6	MGP_CAROLIEiJ_P0077810	MGP_CAROLIEiJ_P0067110	Apolipoprotein E.	Interleukin 6.	0.701
Apoe	Selp	MGP_CAROLIEiJ_P0077810	MGP_CAROLIEiJ_P0020853	Apolipoprotein E.	Selectin, platelet.	0.566
Apoe	Tlr4	MGP_CAROLIEiJ_P0077810	MGP_CAROLIEiJ_P0062683	Apolipoprotein E.	Toll-like receptor 4.	0.565
Blk	Syk	MGP_CAROLIEiJ_P0037100	MGP_CAROLIEiJ_P0034362	Tyrosine-protein kinase Blk.	Tyrosine-protein kinase SYK.	0.462
Ctsg	Il6	MGP_CAROLIEiJ_P0036918	MGP_CAROLIEiJ_P0067110	Cathepsin G.	Interleukin 6.	0.416
Ctsg	Selp	MGP_CAROLIEiJ_P0036918	MGP_CAROLIEiJ_P0020853	Cathepsin G.	Selectin, platelet.	0.423
F11r	Selp	MGP_CAROLIEiJ_P0021219	MGP_CAROLIEiJ_P0020853	Junctional adhesion molecule 1.	Selectin, platelet.	0.579
Fcer1g	Syk	MGP_CAROLIEiJ_P0021133	MGP_CAROLIEiJ_P0034362	High affinity immunoglobulin epsilon receptor subunit gamma.	Tyrosine-protein kinase SYK.	0.998
Fgg	Hrg	MGP_CAROLIEiJ_P0058138	MGP_CAROLIEiJ_P0041067	Fibrinogen gamma chain isoform X1.	Histidine-rich glycoprotein.	0.655
Fgg	Il6	MGP_CAROLIEiJ_P0058138	MGP_CAROLIEiJ_P0067110	Fibrinogen gamma chain isoform X1.	Interleukin 6.	0.402
Flna	Gp1ba	MGP_CAROLIEiJ_P0091839	MGP_CAROLIEiJ_P0027878	Filamin-A isoform X1.	Platelet glycoprotein Ib alpha chain.	0.956
Flna	Gp1bb	MGP_CAROLIEiJ_P0091839	MGP_CAROLIEiJ_P0040835	Filamin-A isoform X1.	Platelet glycoprotein Ib beta chain.	0.720
Flna	Tlr4	MGP_CAROLIEiJ_P0091839	MGP_CAROLIEiJ_P0062683	Filamin-A isoform X1.	Toll-like receptor 4.	0.600
Gnaq	Adrb2	MGP_CAROLIEiJ_P0048330	MGP_CAROLIEiJ_P0046887	Guanine nucleotide-binding protein G(q) subunit alpha.	Adrenergic receptor beta-2.	0.585
Gnaq	Pla2g4a	MGP_CAROLIEiJ_P0048330	MGP_CAROLIEiJ_P0020264	Guanine nucleotide-binding protein G(q) subunit alpha.	Cytosolic phospholipase A2 isoform X1.	0.956
Gnaq	Prkca	MGP_CAROLIEiJ_P0048330	MGP_CAROLIEiJ_P0030650	Guanine nucleotide-binding protein G(q) subunit alpha.	Classical protein kinase C alpha type.	0.452
Gnaq	Ptger3	MGP_CAROLIEiJ_P0048330	MGP_CAROLIEiJ_P0061206	Guanine nucleotide-binding protein G(q) subunit alpha.	Prostaglandin E2 receptor EP3 subtype isoform X1.	0.859