(34 nodes) Negative regulation of cardiac muscle hypertrophy network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Notch1	Neurogenic locus notch homolog protein 1. (2531 aa)
	Atp2b4	Plasma membrane calcium-transporting ATPase 4 isoform X1. (1205 aa)
	Rgs2	Regulator of G-protein signaling 2. (211 aa)
	Rgs4	Regulator of G-protein signaling 4 isoform X1. (204 aa)
	Akap1	A-kinase anchor protein 1, mitochondrial. (890 aa)
	Yy1	Transcriptional repressor protein YY1. (414 aa)
	Jarid2	Protein Jumonji. (1234 aa)
	Fbxo32	F-box only protein 32 isoform X1. (355 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (468 aa)
	Gsk3b	Glycogen synthase kinase 3 beta. (433 aa)
	Tomm70a	Mitochondrial import receptor subunit TOM70. (611 aa)
	Pi16	Peptidase inhibitor 16 isoform X1. (499 aa)
	Smad4	Mothers against decapentaplegic homolog 4. (551 aa)
	Ctdp1	RNA polymerase II subunit A C-terminal domain phosphatase. (960 aa)
	G6pdx	Glucose-6-phosphate 1-dehydrogenase. (515 aa)
	Mlip	Muscular LMNA-interacting protein isoform X1. (967 aa)
	Smad3	Mothers against decapentaplegic homolog 3. (425 aa)
	Glrx3	Glutaredoxin-3 isoform X1. (337 aa)
	Pak1	Serine/threonine-protein kinase PAK 1. (544 aa)
	Gsk3a	Glycogen synthase kinase 3 alpha. (489 aa)
	Zfp418	KRAB domain-containing zinc finger protein. (652 aa)
	Tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (452 aa)
	Pparg	Peroxisome proliferator-activated receptor gamma isoform X1. (505 aa)
	Cav3	Caveolin 3. (151 aa)
	Foxp1	Forkhead box protein P1. (715 aa)
	Bmp10	Bone morphogenetic protein 10. (421 aa)
	P2rx4	P2X purinoceptor 4. (388 aa)
	G6pd2	Glucose-6-phosphate 1-dehydrogenase 2. (514 aa)
	Errfi1	ERBB receptor feedback inhibitor 1. (461 aa)
	Tnfrsf1b	Tumor necrosis factor receptor superfamily member 1B. (474 aa)
	Trim63	Tripartite motif-containing protein 63. (354 aa)
	Lmna	Lamin A/C. (665 aa)
	Foxo1	Forkhead box protein O1. (650 aa)
	Gata5	Transcription factor GATA-5. (345 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp10	Smad4	MGP_CAROLIEiJ_P0074833	MGP_CAROLIEiJ_P0047101	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog 4.	0.503
Cav3	Gsk3b	MGP_CAROLIEiJ_P0075313	MGP_CAROLIEiJ_P0041562	Caveolin 3.	Glycogen synthase kinase 3 beta.	0.445
Fbxo32	Foxo1	MGP_CAROLIEiJ_P0038271	MGP_CAROLIEiJ_P0057614	F-box only protein 32 isoform X1.	Forkhead box protein O1.	0.698
Fbxo32	Trim63	MGP_CAROLIEiJ_P0038271	MGP_CAROLIEiJ_P0065073	F-box only protein 32 isoform X1.	Tripartite motif-containing protein 63.	0.738
Foxo1	Fbxo32	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0038271	Forkhead box protein O1.	F-box only protein 32 isoform X1.	0.698
Foxo1	Gsk3a	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0078025	Forkhead box protein O1.	Glycogen synthase kinase 3 alpha.	0.451
Foxo1	Gsk3b	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0041562	Forkhead box protein O1.	Glycogen synthase kinase 3 beta.	0.651
Foxo1	Lmna	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0058438	Forkhead box protein O1.	Lamin A/C.	0.490
Foxo1	Notch1	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0050383	Forkhead box protein O1.	Neurogenic locus notch homolog protein 1.	0.437
Foxo1	Ppara	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0039338	Forkhead box protein O1.	Peroxisome proliferator-activated receptor alpha.	0.593
Foxo1	Pparg	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0075565	Forkhead box protein O1.	Peroxisome proliferator-activated receptor gamma isoform X1.	0.703
Foxo1	Smad3	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0088272	Forkhead box protein O1.	Mothers against decapentaplegic homolog 3.	0.973
Foxo1	Smad4	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0047101	Forkhead box protein O1.	Mothers against decapentaplegic homolog 4.	0.632
Foxo1	Trim63	MGP_CAROLIEiJ_P0057614	MGP_CAROLIEiJ_P0065073	Forkhead box protein O1.	Tripartite motif-containing protein 63.	0.804
G6pd2	G6pdx	MGP_CAROLIEiJ_P0068234	MGP_CAROLIEiJ_P0091950	Glucose-6-phosphate 1-dehydrogenase 2.	Glucose-6-phosphate 1-dehydrogenase.	0.906
G6pdx	G6pd2	MGP_CAROLIEiJ_P0091950	MGP_CAROLIEiJ_P0068234	Glucose-6-phosphate 1-dehydrogenase.	Glucose-6-phosphate 1-dehydrogenase 2.	0.906
Gsk3a	Foxo1	MGP_CAROLIEiJ_P0078025	MGP_CAROLIEiJ_P0057614	Glycogen synthase kinase 3 alpha.	Forkhead box protein O1.	0.451
Gsk3a	Gsk3b	MGP_CAROLIEiJ_P0078025	MGP_CAROLIEiJ_P0041562	Glycogen synthase kinase 3 alpha.	Glycogen synthase kinase 3 beta.	0.979
Gsk3a	Rgs2	MGP_CAROLIEiJ_P0078025	MGP_CAROLIEiJ_P0020241	Glycogen synthase kinase 3 alpha.	Regulator of G-protein signaling 2.	0.529
Gsk3a	Rgs4	MGP_CAROLIEiJ_P0078025	MGP_CAROLIEiJ_P0021035	Glycogen synthase kinase 3 alpha.	Regulator of G-protein signaling 4 isoform X1.	0.529