(34 nodes) Positive regulation of transforming growth factor beta receptor signaling pathway network (Mus caroli)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cited2	Cbp/p300-interacting transactivator 2. (269 aa)
	Cited1	Cbp/p300-interacting transactivator 1 isoform X1. (203 aa)
	Rnf111	E3 ubiquitin-protein ligase Arkadia isoform X1. (989 aa)
	Gipc1	PDZ domain-containing protein GIPC1. (333 aa)
	Ing2	Inhibitor of growth protein 2. (281 aa)
	Cdkn1c	Cyclin-dependent kinase inhibitor 1C isoform X1. (348 aa)
	Tgfb1i1-2	Transforming growth factor beta 1 induced transcript 1. (350 aa)
	Tgfb1i1	Transforming growth factor beta-1-induced transcript 1 protein isoform X1. (461 aa)
	Furin	Furin isoform X1. (793 aa)
	Hipk2	Homeodomain-interacting protein kinase 2. (1127 aa)
	Tgfbr3	Transforming growth factor beta receptor type 3. (850 aa)
	Cdkn2b	Cyclin-dependent kinase 4 inhibitor B. (130 aa)
	Sdcbp	Syntenin-1 isoform X1. (299 aa)
	Gipc2	PDZ domain-containing protein GIPC2. (314 aa)
	Slc2a10	MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 10. (536 aa)
	Fermt1	Fermitin family homolog 1 isoform X1. (677 aa)
	1700037H04Rik	UPF0687 protein C20orf27 homolog. (177 aa)
	Thbs1	Thrombospondin 1. (1171 aa)
	Zeb2	Zinc finger E-box-binding homeobox 2. (1259 aa)
	Itga8	Integrin alpha-8 isoform X1. (1062 aa)
	Got1	Aspartate aminotransferase, cytoplasmic. (413 aa)
	Men1	Menin isoform X1. (617 aa)
	Smad4	Mothers against decapentaplegic homolog 4. (551 aa)
	Lrg1	Leucine-rich alpha-2-glycoprotein. (342 aa)
	Axin1	Axin-1 isoform X1. (868 aa)
	Crebbp	E1A/CREB-binding protein. (2444 aa)
	Ep300	LOW QUALITY PROTEIN: histone acetyltransferase p300. (2365 aa)
	Dab2	Disabled homolog 2. (766 aa)
	Snw1	SNW domain-containing protein 1. (536 aa)
	Adam17	Disintegrin and metalloproteinase domain-containing protein 17. (846 aa)
	Myocd	Myocardin isoform X1. (983 aa)
	Flcn	Folliculin. (501 aa)
	Gipc3	PDZ domain-containing protein GIPC3. (297 aa)
	Stk11	Serine/threonine-protein kinase STK11 isoform X1. (441 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	Furin	MGP_CAROLIEiJ_P0031984	MGP_CAROLIEiJ_P0080387	Disintegrin and metalloproteinase domain-containing protein 17.	Furin isoform X1.	0.692
Axin1	Dab2	MGP_CAROLIEiJ_P0043428	MGP_CAROLIEiJ_P0037758	Axin-1 isoform X1.	Disabled homolog 2.	0.781
Axin1	Hipk2	MGP_CAROLIEiJ_P0043428	MGP_CAROLIEiJ_P0073331	Axin-1 isoform X1.	Homeodomain-interacting protein kinase 2.	0.813
Axin1	Rnf111	MGP_CAROLIEiJ_P0043428	MGP_CAROLIEiJ_P0088534	Axin-1 isoform X1.	E3 ubiquitin-protein ligase Arkadia isoform X1.	0.779
Axin1	Smad4	MGP_CAROLIEiJ_P0043428	MGP_CAROLIEiJ_P0047101	Axin-1 isoform X1.	Mothers against decapentaplegic homolog 4.	0.449
Axin1	Stk11	MGP_CAROLIEiJ_P0043428	MGP_CAROLIEiJ_P0023840	Axin-1 isoform X1.	Serine/threonine-protein kinase STK11 isoform X1.	0.839
Cdkn1c	Cdkn2b	MGP_CAROLIEiJ_P0083468	MGP_CAROLIEiJ_P0062933	Cyclin-dependent kinase inhibitor 1C isoform X1.	Cyclin-dependent kinase 4 inhibitor B.	0.763
Cdkn2b	Cdkn1c	MGP_CAROLIEiJ_P0062933	MGP_CAROLIEiJ_P0083468	Cyclin-dependent kinase 4 inhibitor B.	Cyclin-dependent kinase inhibitor 1C isoform X1.	0.763
Cdkn2b	Smad4	MGP_CAROLIEiJ_P0062933	MGP_CAROLIEiJ_P0047101	Cyclin-dependent kinase 4 inhibitor B.	Mothers against decapentaplegic homolog 4.	0.479
Cited1	Crebbp	MGP_CAROLIEiJ_P0092381	MGP_CAROLIEiJ_P0040166	Cbp/p300-interacting transactivator 1 isoform X1.	E1A/CREB-binding protein.	0.631
Cited1	Ep300	MGP_CAROLIEiJ_P0092381	MGP_CAROLIEiJ_P0039103	Cbp/p300-interacting transactivator 1 isoform X1.	LOW QUALITY PROTEIN: histone acetyltransferase p300.	0.673
Cited2	Crebbp	MGP_CAROLIEiJ_P0022362	MGP_CAROLIEiJ_P0040166	Cbp/p300-interacting transactivator 2.	E1A/CREB-binding protein.	0.955
Cited2	Ep300	MGP_CAROLIEiJ_P0022362	MGP_CAROLIEiJ_P0039103	Cbp/p300-interacting transactivator 2.	LOW QUALITY PROTEIN: histone acetyltransferase p300.	0.938
Crebbp	Cited1	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0092381	E1A/CREB-binding protein.	Cbp/p300-interacting transactivator 1 isoform X1.	0.631
Crebbp	Cited2	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0022362	E1A/CREB-binding protein.	Cbp/p300-interacting transactivator 2.	0.955
Crebbp	Ep300	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0039103	E1A/CREB-binding protein.	LOW QUALITY PROTEIN: histone acetyltransferase p300.	0.999
Crebbp	Hipk2	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0073331	E1A/CREB-binding protein.	Homeodomain-interacting protein kinase 2.	0.716
Crebbp	Ing2	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0084412	E1A/CREB-binding protein.	Inhibitor of growth protein 2.	0.554
Crebbp	Smad4	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0047101	E1A/CREB-binding protein.	Mothers against decapentaplegic homolog 4.	0.856
Crebbp	Snw1	MGP_CAROLIEiJ_P0040166	MGP_CAROLIEiJ_P0033001	E1A/CREB-binding protein.	SNW domain-containing protein 1.	0.802