(51 nodes) Embryonic cranial skeleton morphogenesis network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tfap2a	Transcription factor AP-2-alpha isoform X1. (440 aa)
	Rdh10	Retinol dehydrogenase 10. (341 aa)
	Twist2	Twist-related protein 2. (160 aa)
	Prrx1	Paired mesoderm homeobox protein 1 isoform X1. (245 aa)
	Tgfb2	Transforming growth factor beta-2 isoform X1. (442 aa)
	Mthfd1l	Monofunctional C1-tetrahydrofolate synthase, mitochondrial. (977 aa)
	Nodal	Nodal homolog. (354 aa)
	Slc39a3	Solute carrier family 39 (zinc transporter), member 1/2/3. (317 aa)
	Chst11	Carbohydrate sulfotransferase 11 isoform X1. (352 aa)
	Lhx1	LIM/homeobox protein Lhx1. (406 aa)
	Wnt9b	Wingless-type MMTV integration site family, member 9. (359 aa)
	Eif4a3	Eukaryotic initiation factor 4A-III. (411 aa)
	Twist1	Twist-related protein 1. (206 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	Six4	Homeobox protein SIX4. (775 aa)
	Tgfb3	Transforming growth factor beta-3. (412 aa)
	Tgfbr2	TGF-beta receptor type-2 isoform X1. (592 aa)
	Setd2	[histone H3]-dimethyl-L-lysine36 N-methyltransferase. (2530 aa)
	Smad3	Mothers against decapentaplegic homolog 3. (425 aa)
	Foxc2	Forkhead box protein C2. (494 aa)
	Irx5	Iroquois-class homeodomain protein IRX-5 isoform X1. (484 aa)
	Fgfr2	Fibroblast growth factor receptor 2 isoform X1. (838 aa)
	Fuz	Protein fuzzy homolog isoform X1. (415 aa)
	Tulp3	Tubby-related protein 3. (463 aa)
	Hoxa2	Homeobox protein HoxA/B2. (372 aa)
	Hoxa1	Homeobox protein Hox-A1 isoform X1. (336 aa)
	Med12	Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2190 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha isoform X1. (1089 aa)
	Wdr19	WD repeat-containing protein 19. (1341 aa)
	Tgfbr1	TGF-beta receptor type-1. (503 aa)
	Pax5	Paired box 5. (390 aa)
	Mmp16	Matrix metalloproteinase-16 (membrane-inserted). (607 aa)
	Alx3	Homeobox protein aristaless-like 3. (341 aa)
	Tbx15	T-box transcription factor TBX15 isoform X1. (602 aa)
	Slc39a1	Solute carrier family 39 (zinc transporter), member 1/2/3. (324 aa)
	Gnas	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1. (1134 aa)
	Dlx2	Homeobox protein DLX-2. (332 aa)
	Prrx2	Paired mesoderm homeobox protein 2 isoform X1. (251 aa)
	Fgf8	Fibroblast growth factor 8 isoform X1. (268 aa)
	Smad2	Mothers against decapentaplegic homolog 2 isoform X1. (467 aa)
	Ndst1	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1. (882 aa)
	Six2	Homeobox protein SIX2. (296 aa)
	Gli3	Transcriptional activator GLI3. (1583 aa)
	Runx2	Runt-related transcription factor 2 isoform X1. (594 aa)
	Ift140	Intraflagellar transport protein 140 homolog. (1464 aa)
	Tbx1	T-box transcription factor TBX1 isoform X1. (488 aa)
	Grhl2	Transcription factor CP2 and related proteins. (625 aa)
	Nipbl	Cohesin loading factor subunit SCC2. (2798 aa)
	Mmp14	Matrix metalloproteinase-14 (membrane-inserted). (582 aa)
	Bmp4	Bone morphogenetic protein 4. (408 aa)
	Mef2c	Myocyte-specific enhancer factor 2C isoform X1. (483 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp4	Dlx2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0052255	Bone morphogenetic protein 4.	Homeobox protein DLX-2.	0.441
Bmp4	Fgf8	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0048966	Bone morphogenetic protein 4.	Fibroblast growth factor 8 isoform X1.	0.645
Bmp4	Fgfr2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0082706	Bone morphogenetic protein 4.	Fibroblast growth factor receptor 2 isoform X1.	0.529
Bmp4	Gli3	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0033730	Bone morphogenetic protein 4.	Transcriptional activator GLI3.	0.400
Bmp4	Mef2c	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0034984	Bone morphogenetic protein 4.	Myocyte-specific enhancer factor 2C isoform X1.	0.410
Bmp4	Pdgfra	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0068689	Bone morphogenetic protein 4.	Platelet-derived growth factor receptor alpha isoform X1.	0.532
Bmp4	Runx2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0044861	Bone morphogenetic protein 4.	Runt-related transcription factor 2 isoform X1.	0.766
Bmp4	Six1	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0032522	Bone morphogenetic protein 4.	Homeobox protein SIX1.	0.402
Bmp4	Smad2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0047151	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog 2 isoform X1.	0.730
Bmp4	Smad3	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0088272	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog 3.	0.688
Bmp4	Tgfbr1	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0062295	Bone morphogenetic protein 4.	TGF-beta receptor type-1.	0.778
Bmp4	Tgfbr2	MGP_CAROLIEiJ_P0036330	MGP_CAROLIEiJ_P0090480	Bone morphogenetic protein 4.	TGF-beta receptor type-2 isoform X1.	0.671
Dlx2	Bmp4	MGP_CAROLIEiJ_P0052255	MGP_CAROLIEiJ_P0036330	Homeobox protein DLX-2.	Bone morphogenetic protein 4.	0.441
Dlx2	Fgf8	MGP_CAROLIEiJ_P0052255	MGP_CAROLIEiJ_P0048966	Homeobox protein DLX-2.	Fibroblast growth factor 8 isoform X1.	0.472
Dlx2	Runx2	MGP_CAROLIEiJ_P0052255	MGP_CAROLIEiJ_P0044861	Homeobox protein DLX-2.	Runt-related transcription factor 2 isoform X1.	0.743
Fgf8	Bmp4	MGP_CAROLIEiJ_P0048966	MGP_CAROLIEiJ_P0036330	Fibroblast growth factor 8 isoform X1.	Bone morphogenetic protein 4.	0.645
Fgf8	Dlx2	MGP_CAROLIEiJ_P0048966	MGP_CAROLIEiJ_P0052255	Fibroblast growth factor 8 isoform X1.	Homeobox protein DLX-2.	0.472
Fgf8	Fgfr2	MGP_CAROLIEiJ_P0048966	MGP_CAROLIEiJ_P0082706	Fibroblast growth factor 8 isoform X1.	Fibroblast growth factor receptor 2 isoform X1.	0.993
Fgf8	Gli3	MGP_CAROLIEiJ_P0048966	MGP_CAROLIEiJ_P0033730	Fibroblast growth factor 8 isoform X1.	Transcriptional activator GLI3.	0.424
Fgf8	Pdgfra	MGP_CAROLIEiJ_P0048966	MGP_CAROLIEiJ_P0068689	Fibroblast growth factor 8 isoform X1.	Platelet-derived growth factor receptor alpha isoform X1.	0.898