(24 nodes) Amyloid-beta metabolic process network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ren1	Renin. (402 aa)
	Ncstn	Nicastrin. (708 aa)
	Bace1	Beta-site APP-cleaving enzyme 1 (memapsin 2). (501 aa)
	Becn1	Beclin-1. (448 aa)
	LOC110296552-2	N-acetyltransferase family 8 member 3. (227 aa)
	LOC110296552	Probable N-acetyltransferase CML3. (227 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (265 aa)
	Mme	Neprilysin. (750 aa)
	Ide	Insulin-degrading enzyme isoform X1. (1044 aa)
	Bace2	Beta-site APP-cleaving enzyme 2 (memapsin 1). (514 aa)
	Dyrk1a	Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1. (763 aa)
	Mgat3	Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase. (538 aa)
	Psen1	Presenilin 1. (467 aa)
	Ace	Angiotensin-converting enzyme. (1312 aa)
	Psen2	Presenilin 2. (448 aa)
	LOC110296552-3	N-acetyltransferase family 8 member 3. (227 aa)
	Abca7	ATP-binding cassette, subfamily A (ABC1), member 7. (2167 aa)
	Apeh	Acylamino-acid-releasing enzyme. (732 aa)
	Nat8f1	N-acetyltransferase 8 (GCN5-related) family member 1. (273 aa)
	Psenen	Gamma-secretase subunit PEN-2. (101 aa)
	Unc13a	Protein unc-13 homolog A. (1733 aa)
	Aph1b	Gamma-secretase subunit APH-1B. (257 aa)
	MGP_CAROLIEiJ_P0088450	Putative gamma-secretase subunit APH-1C. (187 aa)
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (749 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca7	Psen1	MGP_CAROLIEiJ_P0023815	MGP_CAROLIEiJ_P0032762	ATP-binding cassette, subfamily A (ABC1), member 7.	Presenilin 1.	0.562
Abca7	Psen2	MGP_CAROLIEiJ_P0023815	MGP_CAROLIEiJ_P0021594	ATP-binding cassette, subfamily A (ABC1), member 7.	Presenilin 2.	0.577
Ace	Ide	MGP_CAROLIEiJ_P0030507	MGP_CAROLIEiJ_P0048668	Angiotensin-converting enzyme.	Insulin-degrading enzyme isoform X1.	0.418
Ace	Mme	MGP_CAROLIEiJ_P0030507	MGP_CAROLIEiJ_P0057849	Angiotensin-converting enzyme.	Neprilysin.	0.732
Ace	Ren1	MGP_CAROLIEiJ_P0030507	MGP_CAROLIEiJ_P0019874	Angiotensin-converting enzyme.	Renin.	0.846
Adam10	Aph1b	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0088448	Disintegrin and metalloproteinase domain-containing protein 10.	Gamma-secretase subunit APH-1B.	0.416
Adam10	Bace1	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0087647	Disintegrin and metalloproteinase domain-containing protein 10.	Beta-site APP-cleaving enzyme 1 (memapsin 2).	0.726
Adam10	Bace2	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0042539	Disintegrin and metalloproteinase domain-containing protein 10.	Beta-site APP-cleaving enzyme 2 (memapsin 1).	0.485
Adam10	Ide	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0048668	Disintegrin and metalloproteinase domain-containing protein 10.	Insulin-degrading enzyme isoform X1.	0.538
Adam10	MGP_CAROLIEiJ_P0088450	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0088450	Disintegrin and metalloproteinase domain-containing protein 10.	Putative gamma-secretase subunit APH-1C.	0.400
Adam10	Mme	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0057849	Disintegrin and metalloproteinase domain-containing protein 10.	Neprilysin.	0.498
Adam10	Ncstn	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0021254	Disintegrin and metalloproteinase domain-containing protein 10.	Nicastrin.	0.663
Adam10	Psen1	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0032762	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin 1.	0.641
Adam10	Psen2	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0021594	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin 2.	0.587
Adam10	Psenen	MGP_CAROLIEiJ_P0088540	MGP_CAROLIEiJ_P0078697	Disintegrin and metalloproteinase domain-containing protein 10.	Gamma-secretase subunit PEN-2.	0.618
Apeh	Ncstn	MGP_CAROLIEiJ_P0089894	MGP_CAROLIEiJ_P0021254	Acylamino-acid-releasing enzyme.	Nicastrin.	0.744
Apeh	Psenen	MGP_CAROLIEiJ_P0089894	MGP_CAROLIEiJ_P0078697	Acylamino-acid-releasing enzyme.	Gamma-secretase subunit PEN-2.	0.661
Aph1a	Aph1b	MGP_CAROLIEiJ_P0059263	MGP_CAROLIEiJ_P0088448	Gamma-secretase subunit APH-1A.	Gamma-secretase subunit APH-1B.	0.964
Aph1a	Bace1	MGP_CAROLIEiJ_P0059263	MGP_CAROLIEiJ_P0087647	Gamma-secretase subunit APH-1A.	Beta-site APP-cleaving enzyme 1 (memapsin 2).	0.416
Aph1a	MGP_CAROLIEiJ_P0088450	MGP_CAROLIEiJ_P0059263	MGP_CAROLIEiJ_P0088450	Gamma-secretase subunit APH-1A.	Putative gamma-secretase subunit APH-1C.	0.964