(21 nodes) Leukocyte tethering or rolling network (Mus caroli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Selplg	P-selectin glycoprotein ligand 1. (398 aa)
	Lep	Leptin. (167 aa)
	Add2	Beta-adducin. (639 aa)
	Itgb7	Integrin beta 7. (806 aa)
	Podxl2	Podocalyxin-like protein 2. (589 aa)
	Spn	Leukosialin. (386 aa)
	Chst4	Carbohydrate 6-sulfotransferase 4. (388 aa)
	Itgb1	Integrin beta 1. (798 aa)
	Cx3cr1	CX3C chemokine receptor 1. (354 aa)
	Jam2	Junctional adhesion molecule B isoform X1. (298 aa)
	Tnf	Tumor necrosis factor superfamily, member 2. (235 aa)
	Rock1	Rho-associated protein kinase 1 isoform X1. (1354 aa)
	Gcnt1	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase. (428 aa)
	Itga4	Integrin alpha 4. (1032 aa)
	Vcam1	Vascular cell adhesion molecule 1. (739 aa)
	Sele	Selectin, endothelial cell. (619 aa)
	Sell	L-selectin isoform X1. (387 aa)
	Selp	Selectin, platelet. (768 aa)
	Madcam1	Mucosal addressin cell adhesion molecule 1 isoform X1. (405 aa)
	Golph3	Golgi phosphoprotein 3. (168 aa)
	Ext1	Glucuronyl/N-acetylglucosaminyl transferase EXT1. (746 aa)

Your Current Organism:

Mus caroli

NCBI taxonomy Id: 10089
Other names: M. caroli, Mus formosanus, Ryukyu mouse, ricefield mouse

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chst4	Gcnt1	MGP_CAROLIEiJ_P0085998	MGP_CAROLIEiJ_P0048339	Carbohydrate 6-sulfotransferase 4.	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.	0.558
Chst4	Sell	MGP_CAROLIEiJ_P0085998	MGP_CAROLIEiJ_P0020851	Carbohydrate 6-sulfotransferase 4.	L-selectin isoform X1.	0.587
Cx3cr1	Sell	MGP_CAROLIEiJ_P0090580	MGP_CAROLIEiJ_P0020851	CX3C chemokine receptor 1.	L-selectin isoform X1.	0.489
Cx3cr1	Tnf	MGP_CAROLIEiJ_P0090580	MGP_CAROLIEiJ_P0044486	CX3C chemokine receptor 1.	Tumor necrosis factor superfamily, member 2.	0.533
Cx3cr1	Vcam1	MGP_CAROLIEiJ_P0090580	MGP_CAROLIEiJ_P0060107	CX3C chemokine receptor 1.	Vascular cell adhesion molecule 1.	0.596
Gcnt1	Chst4	MGP_CAROLIEiJ_P0048339	MGP_CAROLIEiJ_P0085998	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.	Carbohydrate 6-sulfotransferase 4.	0.558
Gcnt1	Sele	MGP_CAROLIEiJ_P0048339	MGP_CAROLIEiJ_P0020848	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.	Selectin, endothelial cell.	0.404
Gcnt1	Selplg	MGP_CAROLIEiJ_P0048339	MGP_CAROLIEiJ_P0069928	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.	P-selectin glycoprotein ligand 1.	0.426
Itga4	Itgb1	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0086610	Integrin alpha 4.	Integrin beta 1.	0.999
Itga4	Itgb7	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0039964	Integrin alpha 4.	Integrin beta 7.	0.999
Itga4	Jam2	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0042095	Integrin alpha 4.	Junctional adhesion molecule B isoform X1.	0.965
Itga4	Madcam1	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0023717	Integrin alpha 4.	Mucosal addressin cell adhesion molecule 1 isoform X1.	0.923
Itga4	Sele	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0020848	Integrin alpha 4.	Selectin, endothelial cell.	0.624
Itga4	Sell	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0020851	Integrin alpha 4.	L-selectin isoform X1.	0.630
Itga4	Selp	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0020853	Integrin alpha 4.	Selectin, platelet.	0.598
Itga4	Selplg	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0069928	Integrin alpha 4.	P-selectin glycoprotein ligand 1.	0.410
Itga4	Tnf	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0044486	Integrin alpha 4.	Tumor necrosis factor superfamily, member 2.	0.574
Itga4	Vcam1	MGP_CAROLIEiJ_P0052495	MGP_CAROLIEiJ_P0060107	Integrin alpha 4.	Vascular cell adhesion molecule 1.	0.994
Itgb1	Itga4	MGP_CAROLIEiJ_P0086610	MGP_CAROLIEiJ_P0052495	Integrin beta 1.	Integrin alpha 4.	0.999
Itgb1	Itgb7	MGP_CAROLIEiJ_P0086610	MGP_CAROLIEiJ_P0039964	Integrin beta 1.	Integrin beta 7.	0.780