STRINGSTRING
Tff2 Tff2 Muc5ac Muc5ac Muc3 Muc3 Muc4 Muc4 Muc15 Muc15 Muc13 Muc13 Muc20 Muc20 Muc5b Muc5b Gm9573 Gm9573 Muc6 Muc6 Muc2 Muc2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tff2Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). (129 aa)
Muc5acMucin 5, subtypes A and C, tracheobronchial/gastric. (2751 aa)
Muc3Mucin 3, intestinal. (378 aa)
Muc4Mucin-4. (3470 aa)
Muc15Mucin-15. (331 aa)
Muc13Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. (573 aa)
Muc20Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity). (688 aa)
Muc5bMucin 5, subtype B, tracheobronchial. (4800 aa)
Gm9573Predicted gene 9573. (1606 aa)
Muc6Mucin-6; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. (2918 aa)
Muc2Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. (923 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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