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Exoc6b Exoc6b Stard3nl Stard3nl Exoc5 Exoc5 Trappc12 Trappc12 Trappc4 Trappc4 Trappc3 Trappc3 Exoc7 Exoc7 Trappc6b Trappc6b Trip11 Trip11 Trappc13 Trappc13 Trappc8 Trappc8 Wdr11 Wdr11 Exoc8 Exoc8 Trappc5 Trappc5 Tbc1d23 Tbc1d23 Stard3 Stard3 Trappc2l Trappc2l Trappc6a Trappc6a Trappc10 Trappc10 5730455P16Rik 5730455P16Rik Trappc1 Trappc1 Exoc2 Exoc2 Trappc9 Trappc9 Exoc6 Exoc6 Exoc4 Exoc4 Trappc11 Trappc11 Exoc3 Exoc3 Fam91a1 Fam91a1 Exoc1 Exoc1 Trappc2 Trappc2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Exoc6bExocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (810 aa)
Stard3nlSTARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB. (263 aa)
Exoc5Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (708 aa)
Trappc12Trafficking protein particle complex subunit 12; Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores. (797 aa)
Trappc4Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi. May play a role in dendrite postsynaptic membrane trafficking; Belongs to the TRAPP small subunits family. TRAPPC4 subfamily. (219 aa)
Trappc3Trafficking protein particle complex subunit 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily. (180 aa)
Exoc7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion; Belongs to the EXO70 family. (697 aa)
Trappc6bTrafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity). Belongs to the TRAPP small subunits family. BET3 subfamily. (158 aa)
Trip11Thyroid hormone receptor interactor 11. (1976 aa)
Trappc13Trafficking protein particle complex subunit 13; Belongs to the TRAPPC13 family. (418 aa)
Trappc8Trafficking protein particle complex 8. (1437 aa)
Wdr11WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)- derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (By similarity). (1223 aa)
Exoc8Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (716 aa)
Trappc5Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily. (188 aa)
Tbc1d23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly t [...] (684 aa)
Stard3StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] (446 aa)
Trappc2lTrafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (139 aa)
Trappc6aTrafficking protein particle complex subunit 6A; May play a role in vesicular transport during the biogenesis of melanosomes. (159 aa)
Trappc10Trafficking protein particle complex subunit 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (1258 aa)
5730455P16RikProtein Njmu-R1; May have a role in spermatogenesis. (393 aa)
Trappc1Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (145 aa)
Exoc2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
Trappc9Trafficking protein particle complex subunit 9; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. (1139 aa)
Exoc6Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis; Belongs to the SEC15 family. (804 aa)
Exoc4Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC8 family. (975 aa)
Trappc11Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Belongs to the TRAPPC11 family. (1133 aa)
Exoc3Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (755 aa)
Fam91a1Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. (837 aa)
Exoc1Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (901 aa)
Trappc2Trafficking protein particle complex subunit 2; Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). (140 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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