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Fau Fau Rps28 Rps28 Rps27 Rps27 Rpl14 Rpl14 Rpl26 Rpl26 Rps13 Rps13 Rpl10-ps3 Rpl10-ps3 Rpl27a Rpl27a Zcchc17 Zcchc17 Rps20 Rps20 Uba52 Uba52 Rps15a Rps15a Apod Apod Repin1 Repin1 Rpl22 Rpl22 Rpl29 Rpl29 Rpl12 Rpl12 Ppargc1a Ppargc1a Rpl13a Rpl13a Rpl39 Rpl39 Rpl35a Rpl35a Rps10 Rps10 Rpl9 Rpl9 Rpl19 Rpl19 Rpl36a Rpl36a Rpl36al Rpl36al Rpl30 Rpl30 Rps9 Rps9 Rps5 Rps5 Rps19 Rps19 Rps16 Rps16 Rpl27 Rpl27 Rpl38 Rpl38 Rpl10l Rpl10l Mcts2 Mcts2 Rpl7a Rpl7a Rps27a Rps27a Rps6 Rps6 Gm2000 Gm2000 Rps8 Rps8 Rpl11 Rpl11 Rpl23a Rpl23a Rpl23 Rpl23 Larp4 Larp4 Rps2 Rps2 Hba-a2 Hba-a2 Gm11808 Gm11808 Rpl34 Rpl34 Rpl31 Rpl31 Rplp0 Rplp0 Rpl10 Rpl10 Rpl5 Rpl5 Rpl3 Rpl3 Rpl35 Rpl35 Rps17 Rps17 Rpl36 Rpl36 Rps25 Rps25 Rpl15 Rpl15 Rps7 Rps7 Rpl7 Rpl7 Rps15 Rps15 Eif2d Eif2d Rps27rt Rps27rt Rpl37a Rpl37a Rps21 Rps21 Rpl18a Rpl18a Rps23 Rps23 Rpl10a Rpl10a Rps18 Rps18 Rplp1 Rplp1 Eif2ak4 Eif2ak4 Rpl37 Rpl37 Rpl21 Rpl21 Mcts1 Mcts1 Rpl13 Rpl13 Ddx3x Ddx3x Rps11 Rps11 Rps29 Rps29 D1Pas1 D1Pas1 Dhx29 Dhx29 Rpsa Rpsa Rpl4 Rpl4 Rps4x Rps4x Rps3 Rps3 Rpl28 Rpl28 Rpl6 Rpl6 Rps3a1 Rps3a1 Rps26 Rps26 Rpl24 Rpl24 Rps14 Rps14 Rpl17 Rpl17 Rpl8 Rpl8 Rps24 Rps24 Rps12 Rps12 Rpl18 Rpl18 Rpl32 Rpl32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FauUbiquitin-like protein FUBI; Belongs to the ubiquitin family. (133 aa)
Rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (69 aa)
Rps27Ribosomal protein S27. (84 aa)
Rpl1460S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family. (217 aa)
Rpl2660S ribosomal protein L26; Component of the large ribosomal subunit. (145 aa)
Rps1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
Rpl10-ps3Ribosomal protein L10, pseudogene 3. (214 aa)
Rpl27a60S ribosomal protein L27a. (148 aa)
Zcchc17Nucleolar protein of 40 kDa. (241 aa)
Rps2040S ribosomal protein S20. (119 aa)
Uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
Rps15a40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family. (130 aa)
ApodApolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
Repin1Replication initiator 1; Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'- ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity). (601 aa)
Rpl2260S ribosomal protein L22. (128 aa)
Rpl2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (160 aa)
Rpl1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA. (165 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (797 aa)
Rpl13a60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as cerupla [...] (203 aa)
Rpl3960S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
Rpl35a60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. (110 aa)
Rps1040S ribosomal protein S10; Component of the 40S ribosomal subunit. (165 aa)
Rpl960S ribosomal protein L9; Belongs to the universal ribosomal protein uL6 family. (192 aa)
Rpl1960S ribosomal protein L19. (196 aa)
Rpl36aRibosomal protein L36A. (106 aa)
Rpl36al60S ribosomal protein L36a. (106 aa)
Rpl3060S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family. (115 aa)
Rps940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
Rps540S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. (204 aa)
Rps1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
Rps1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (146 aa)
Rpl2760S ribosomal protein L27; Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). (136 aa)
Rpl3860S ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
Rpl10l60S ribosomal protein L10-like; Belongs to the universal ribosomal protein uL16 family. (214 aa)
Mcts2Malignant T-cell-amplified sequence 2. (181 aa)
Rpl7a60S ribosomal protein L7a. (266 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Rps640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
Gm2000Predicted gene 2000. (123 aa)
Rps840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
Rpl1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (178 aa)
Rpl23a60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. (156 aa)
Rpl2360S ribosomal protein L23. (140 aa)
Larp4La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization. (719 aa)
Rps240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (293 aa)
Hba-a2Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
Gm11808Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
Rpl3460S ribosomal protein L34; Component of the large ribosomal subunit. (117 aa)
Rpl3160S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. (125 aa)
Rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
Rpl1060S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. (214 aa)
Rpl560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
Rpl360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (403 aa)
Rpl3560S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family. (123 aa)
Rps1740S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family. (135 aa)
Rpl3660S ribosomal protein L36; Component of the large ribosomal subunit. (105 aa)
Rps2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (125 aa)
Rpl1560S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
Rps740S ribosomal protein S7; Required for rRNA maturation. (194 aa)
Rpl760S ribosomal protein L7; Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (270 aa)
Rps1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
Eif2dEukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its [...] (570 aa)
Rps27rt40S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). (84 aa)
Rpl37a60S ribosomal protein L37a; Belongs to the eukaryotic ribosomal protein eL43 family. (92 aa)
Rps2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
Rpl18a60S ribosomal protein L18a. (176 aa)
Rps2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
Rpl10a60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family. (217 aa)
Rps1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
Rplp160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
Eif2ak4eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2- alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a transl [...] (1648 aa)
Rpl3760S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (97 aa)
Rpl2160S ribosomal protein L21; Component of the large ribosomal subunit. (160 aa)
Mcts1Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] (181 aa)
Rpl1360S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (211 aa)
Ddx3xATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 t [...] (662 aa)
Rps1140S ribosomal protein S11. (158 aa)
Rps2940S ribosomal protein S29. (56 aa)
D1Pas1Putative ATP-dependent RNA helicase Pl10; Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process; Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (660 aa)
Dhx29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1365 aa)
Rpsa40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
Rpl460S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (419 aa)
Rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
Rps340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] (243 aa)
Rpl2860S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family. (137 aa)
Rpl660S ribosomal protein L6; Component of the large ribosomal subunit. (296 aa)
Rps3a140S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
Rps2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
Rpl2460S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (157 aa)
Rps1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
Rpl1760S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family. (184 aa)
Rpl860S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family. (257 aa)
Rps2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. (133 aa)
Rps1240S ribosomal protein S12. (132 aa)
Rpl1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
Rpl3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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