STRINGSTRING
Wfikkn1 Wfikkn1 Slco1a5 Slco1a5 Gm6614 Gm6614 Gm10267 Gm10267 Agrn Agrn Spock1 Spock1 Spink8 Spink8 Gm36368 Gm36368 Slco6d1 Slco6d1 Tmeff1 Tmeff1 Spink4 Spink4 Reck Reck Sparcl1 Sparcl1 Slco1c1 Slco1c1 Slco2a1 Slco2a1 Igfbpl1 Igfbpl1 Slco1a1 Slco1a1 Fstl5 Fstl5 Fstl4 Fstl4 Slco1b2 Slco1b2 Slco4a1 Slco4a1 Wfikkn2 Wfikkn2 Spink14 Spink14 Spink10 Spink10 Spinkl Spinkl Spink5 Spink5 Spink2 Spink2 Spink6 Spink6 Htra1 Htra1 Sparc Sparc Fstl3 Fstl3 Smoc2 Smoc2 Spink1 Spink1 Slco3a1 Slco3a1 Slco6c1 Slco6c1 Fst Fst Slco4c1 Slco4c1 Spink7 Spink7 Cfi Cfi Spink12 Spink12 Tmeff2 Tmeff2 Htra4 Htra4 Htra3 Htra3 Spink13 Spink13 Gm10542 Gm10542 Spink11 Spink11 Slco2b1 Slco2b1 Smoc1 Smoc1 Slco1a6 Slco1a6 Kazald1 Kazald1 Fstl1 Fstl1 Slco5a1 Slco5a1 Spock3 Spock3 Spock2 Spock2 Gm5724 Gm5724 Igfbp7 Igfbp7 Slco1a4 Slco1a4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Wfikkn1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). (552 aa)
Slco1a5Solute carrier organic anion transporter family member 1A5; Mediates the Na(+)-independent transport of organic anions such as taurocholate and thyroid hormones; Belongs to the organo anion transporter (TC 2.A.60) family. (670 aa)
Gm6614Solute carrier organic anion transporter family member. (650 aa)
Gm10267Predicted gene 10267. (85 aa)
AgrnAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium [...] (2034 aa)
Spock1Testican-1; May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. (442 aa)
Spink8Serine protease inhibitor Kazal-type 8; Probable serine protease inhibitor. (105 aa)
Gm36368Predicted gene, 36368. (91 aa)
Slco6d1Solute carrier organic anion transporter family, member 6d1. (683 aa)
Tmeff1Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning. Belongs to the tomoregulin family. (372 aa)
Spink4Serine protease inhibitor Kazal-type 4. (86 aa)
ReckReversion-inducing cysteine-rich protein with Kazal motifs; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7- specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity). ADGRA2 is then required to deliver RECK-bound [...] (971 aa)
Sparcl1SPARC-like protein 1; Belongs to the SPARC family. (650 aa)
Slco1c1Solute carrier organic anion transporter family member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol- 17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a significant role in regulating T4 flux into and out of the brain (By similarity). (715 aa)
Slco2a1Solute carrier organic anion transporter family member 2A1; May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A; Belongs to the organo anion transporter (TC 2.A.60) family. (643 aa)
Igfbpl1Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). (270 aa)
Slco1a1Solute carrier organic anion transporter family member 1A1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, prostaglandin E2 (PGE2), dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate, sulfobromophthalein (BSP), ouabain and gadoxetate; Belongs to the organo anion transporter (TC 2.A.60) family. (670 aa)
Fstl5Follistatin-related protein 5. (847 aa)
Fstl4Follistatin-related protein 4. (841 aa)
Slco1b2Solute carrier organic anion transporter family member 1B2; Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2; Belongs to the organo anion transporter (TC 2.A.60) family. (689 aa)
Slco4a1Solute carrier organic anion transporter family member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormone T3 (triiodo-L-thyronine) and of taurocholate. (723 aa)
Wfikkn2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). Inhibits the biological activity of mature myostatin, but not activin; Belongs to the WFIKKN family. (571 aa)
Spink14Serine peptidase inhibitor, Kazal type 14. (96 aa)
Spink10Serine protease inhibitor Kazal-type 10; Probable serine protease inhibitor. (162 aa)
SpinklSerine protease inhibitor kazal-like protein, major form; Does not function as an inhibitor of trypsin, chymotrypsin, subtilisin or elastase. Binds sperm and enhances sperm motility. May act as a decapacitation factor, suppresses BSA-stimulated sperm capacitation and blocks sperm-oocyte interactions in vitro. (90 aa)
Spink5Serine peptidase inhibitor, Kazal type 5. (1017 aa)
Spink2Serine protease inhibitor Kazal-type 2; As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin. (86 aa)
Spink6Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8. (105 aa)
Htra1Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] (480 aa)
SparcSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; Belongs to the SPARC family. (302 aa)
Fstl3Follistatin-related protein 3; The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nucl [...] (256 aa)
Smoc2SPARC-related modular calcium-binding protein 2; Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness. (447 aa)
Spink1Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. (80 aa)
Slco3a1Solute carrier organic anion transporter family member 3A1; Mediates the Na(+)-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin. (710 aa)
Slco6c1Solute carrier organic anion transporter family, member 6c1. (706 aa)
FstFollistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (343 aa)
Slco4c1Solute carrier organic anion transporter family member 4C1; Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by en [...] (722 aa)
Spink7Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. (85 aa)
CfiComplement factor I heavy chain; Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired [...] (603 aa)
Spink12Serine protease inhibitor Kazal-type 12; Inhibits trypsin. (105 aa)
Tmeff2Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity). (374 aa)
Htra4Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. (483 aa)
Htra3Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). (459 aa)
Spink13Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). (97 aa)
Gm10542Predicted gene 10542. (90 aa)
Spink11Serine protease inhibitor Kazal-type 11; Probable serine protease inhibitor. (114 aa)
Slco2b1Solute carrier organic anion transporter family member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost; Belongs to the organo anion transporter (TC 2.A.60) family. (693 aa)
Smoc1SPARC-related modular calcium-binding protein 1; Probable regulator of osteoblast differentiation. Plays essential roles in both eye and limb development. (463 aa)
Slco1a6Solute carrier organic anion transporter family member 1A6; May mediate the Na(+)-independent transport of organic anions; Belongs to the organo anion transporter (TC 2.A.60) family. (670 aa)
Kazald1Kazal-type serine protease inhibitor domain-containing protein 1; Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly. (313 aa)
Fstl1Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). (306 aa)
Slco5a1Solute carrier organic anion transporter family member. (850 aa)
Spock3Testican-3; May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion (By similarity). (436 aa)
Spock2Testican-2; May participate in diverse steps of neurogenesis. Binds calcium (By similarity). (423 aa)
Gm5724Solute carrier organic anion transporter family member. (670 aa)
Igfbp7Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity). (313 aa)
Slco1a4Solute carrier organic anion transporter family member 1A4; Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone- 3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones; Belongs to the organo anion transporter (TC 2.A.60) family. (670 aa)
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.