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| Aff3 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. (1229 aa) | ||||
| Aff4 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family. (1160 aa) | ||||
| Aff2 | AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure; Belongs to the AF4 family. (1272 aa) | ||||
| Aff1 | AF4/FMR2 family member 1; Belongs to the AF4 family. (1226 aa) | ||||