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Pla2g1b Pla2g1b Pcyt1a Pcyt1a Pafah1b1 Pafah1b1 Pla2g10 Pla2g10 Lpcat4 Lpcat4 Phospho1 Phospho1 Lypla1 Lypla1 Pnpla7 Pnpla7 Enpp6 Enpp6 Lypla2 Lypla2 Chkb Chkb Pcyt1b Pcyt1b Lpcat3 Lpcat3 Etnk1 Etnk1 Ptdss2 Ptdss2 Lpcat2 Lpcat2 Pla2g2f Pla2g2f Pla2g2d Pla2g2d Pla2g5 Pla2g5 Pla2g2a Pla2g2a Chka Chka Lpcat1 Lpcat1 Pisd Pisd Gdpd3 Gdpd3 Pla2g15 Pla2g15 Fads2 Fads2 Pafah1b3 Pafah1b3 Pla2g4e Pla2g4e Pla2g3 Pla2g3 Pla2g7 Pla2g7 Pld4 Pld4 Cept1 Cept1 Pafah2 Pafah2 Mboat1 Mboat1 Plaat3 Plaat3 Pcyt2 Pcyt2 Pld2 Pld2 Pld3 Pld3 Pla2g4c Pla2g4c Plb1 Plb1 Pla2g4b Pla2g4b Etnk2 Etnk2 Lpgat1 Lpgat1 Pnpla6 Pnpla6 Etnppl Etnppl Pla2g12b Pla2g12b Pafah1b2 Pafah1b2 Tmem189 Tmem189 Tmem86b Tmem86b Ptdss1 Ptdss1 Pla1a Pla1a Chpt1 Chpt1 Pla2g2c Pla2g2c Selenoi Selenoi Pld1 Pld1 Pla2g12a Pla2g12a Lpcat2b Lpcat2b Pemt Pemt Gpcpd1 Gpcpd1 Pla2g4a Pla2g4a
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Pla2g1bPhospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (146 aa)
Pcyt1aCholine-phosphate cytidylyltransferase A; Controls phosphatidylcholine synthesis; Belongs to the cytidylyltransferase family. (367 aa)
Pafah1b1Platelet-activating factor acetylhydrolase IB subunit alpha; Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule slidi [...] (410 aa)
Pla2g10Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids (By similarity). Belongs to the phospholipase A2 family. (151 aa)
Lpcat4Lysophosphatidylcholine acyltransferase 4. (522 aa)
Phospho1Phosphoethanolamine/phosphocholine phosphatase 1. (289 aa)
Lypla1Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity). (230 aa)
Pnpla7Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. (1349 aa)
Enpp6Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. (440 aa)
Lypla2Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). (231 aa)
ChkbCholine/ethanolamine kinase; Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis. (394 aa)
Pcyt1bCholine-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis. (369 aa)
Lpcat3Lysophospholipid acyltransferase 5; Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity). (487 aa)
Etnk1Ethanolamine kinase 1 (Predicted). (363 aa)
Ptdss2Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity); Belongs to the phosphatidyl serine synthase family. (471 aa)
Lpcat2Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, ac [...] (544 aa)
Pla2g2fPhospholipase A(2). (210 aa)
Pla2g2dPhospholipase A(2). (144 aa)
Pla2g5Calcium-dependent phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L-alpha- palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1- palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2- arachidonyl phosphatidylethanolamine or L-alpha-1-stearoyl-2- arachidonyl phosphatidylinositol. (137 aa)
Pla2g2aPhospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Independent of its catalytic activity, activates integrins by binding to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and inducing integrin conformational changes and enhanced ligand binding to site [...] (146 aa)
ChkaCholine kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (By similarity). (453 aa)
Lpcat1Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3- phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1- myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size (By similarity). (534 aa)
PisdPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (406 aa)
Gdpd3Glycerophosphodiester phosphodiesterase domain-containing 3. (330 aa)
Pla2g15Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (413 aa)
Fads2Acyl-CoA 6-desaturase; Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA [...] (386 aa)
Pafah1b3Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain. (232 aa)
Pla2g4ePhospholipase A2. (828 aa)
Pla2g3Phospholipase A2, group III (Predicted), isoform CRA_a. (506 aa)
Pla2g7Platelet-activating factor acetylhydrolase. (440 aa)
Pld4Similar to phospholipase D family, member 4. (529 aa)
Cept1Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (By similarity). (416 aa)
Pafah2Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme. Catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N- acetylsphingosine (C2-ceramide) respectively. Acts as a PAF- acetylhydrolase in the absence of lipid acceptor molecules. (390 aa)
Mboat1Membrane-bound O-acyltransferase domain-containing 1; Belongs to the membrane-bound acyltransferase family. (492 aa)
Plaat3Phospholipase A and acyltransferase 3; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), ccatalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer o [...] (160 aa)
Pcyt2Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP- ethanolamine (By similarity); Belongs to the cytidylyltransferase family. (404 aa)
Pld2Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Belongs to the phospholipase D family. (931 aa)
Pld35'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (488 aa)
Pla2g4cPhospholipase A2 group IVC. (604 aa)
Plb1Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. (1111 aa)
Pla2g4bPhospholipase A2. (791 aa)
Etnk2Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity. (191 aa)
Lpgat1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
Pnpla6Patatin-like phospholipase domain-containing 6. (1354 aa)
EtnpplEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (499 aa)
Pla2g12bPhospholipase A2, group XIIB. (195 aa)
Pafah1b2Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. (229 aa)
Tmem189Transmembrane protein 189. (258 aa)
Tmem86bLysoplasmalogenase; Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties. (233 aa)
Ptdss1Phosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity). (502 aa)
Pla1aPhospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. (456 aa)
Chpt1Cholinephosphotransferase 1; Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity). (398 aa)
Pla2g2cGroup IIC secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides; Belongs to the phospholipase A2 family. (158 aa)
SelenoiSelenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (394 aa)
Pld1Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). (1077 aa)
Pla2g12aPhospholipase A2, group XIIA. (192 aa)
Lpcat2bLysophosphatidylcholine acyltransferase 2B; Probable acetyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (517 aa)
PemtPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). (199 aa)
Gpcpd1Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. (671 aa)
Pla2g4aCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (752 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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