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Cyp4f6 Cyp4f6 Cyp19a1 Cyp19a1 Cyp3a18 Cyp3a18 Cyp2b15 Cyp2b15 Cyp4f5 Cyp4f5 Cyp2d4 Cyp2d4 Cyp2d2 Cyp2d2 Cyp4a8 Cyp4a8 Cyp4b1 Cyp4b1 Cyp2c12 Cyp2c12 Cyp2e1 Cyp2e1 Cyp1a2 Cyp1a2 Cyp1a1 Cyp1a1 Cyp2a1 Cyp2a1 Cyp2g1 Cyp2g1 Cyp2b3 Cyp2b3 LOC100910127 LOC100910127 Cyp2d5 Cyp2d5 Cyp2b21 Cyp2b21 Cyp2c7 Cyp2c7 Cyp2b2 Cyp2b2 Cyp2b1 Cyp2b1 Cyp2c24 Cyp2c24 Cyp2c6v1 Cyp2c6v1 Cyp2j10 Cyp2j10 Cyp2c13 Cyp2c13 Cyp3a9 Cyp3a9 Cyp3a2 Cyp3a2 Cyp2d1 Cyp2d1 Cyp2b12 Cyp2b12 Cyp1b1 Cyp1b1 LOC103691072 LOC103691072 Cyp2c11 Cyp2c11 Cyp3a62 Cyp3a62 LOC100361492 LOC100361492
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Cyp4f6Cytochrome P450 4F6; Belongs to the cytochrome P450 family. (537 aa)
Cyp19a1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (503 aa)
Cyp3a18Cytochrome P450 3A18; Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone. (497 aa)
Cyp2b15Cytochrome P450 2B15; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity). (495 aa)
Cyp4f5Cytochrome P450 4F5; Belongs to the cytochrome P450 family. (526 aa)
Cyp2d4Cytochrome P450 2D4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa)
Cyp2d2Cytochrome P450 2D26; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa)
Cyp4a8Cytochrome P450 4A12; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (508 aa)
Cyp4b1Cytochrome P450 4B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (511 aa)
Cyp2c12Cytochrome P450 2C12, female-specific; This P450 is active in 15-beta-hydroxylation of steroid sulfates. (490 aa)
Cyp2e1Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (493 aa)
Cyp1a2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (513 aa)
Cyp1a1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (524 aa)
Cyp2a1Cytochrome P450 2A2; Highly active in the 15-alpha-hydroxylation of testosterone. (494 aa)
Cyp2g1Cytochrome P450 2G1; Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction. (494 aa)
Cyp2b3Cytochrome P450 2B3; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
LOC100910127Cytochrome P450 2B15-like; Belongs to the cytochrome P450 family. (492 aa)
Cyp2d5Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (504 aa)
Cyp2b21Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family. (494 aa)
Cyp2c7Cytochrome P450 2C7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (490 aa)
Cyp2b2Cytochrome P450 2B2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa)
Cyp2b1Cytochrome P450 2B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (499 aa)
Cyp2c24Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE). (490 aa)
Cyp2c6v1Cytochrome P450 2C6; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (490 aa)
Cyp2j10Cytochrome P450 2J3; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9- epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA). (502 aa)
Cyp2c13Cytochrome P450 2C13, male-specific; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (490 aa)
Cyp3a9Cytochrome P450 3A9; This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine. (503 aa)
Cyp3a2Cytochrome P450 3A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (502 aa)
Cyp2d1Cytochrome P450 2D3; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (509 aa)
Cyp2b12Cytochrome P450 2B12; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. (492 aa)
Cyp1b1Cytochrome P450 1B1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2. Metabolizes testosterone and progesterone [...] (541 aa)
LOC103691072Uncharacterized protein. (379 aa)
Cyp2c11Cytochrome P450 2C11; Metabolizes testosterone mainly in positions 2 alpha and 16 alpha; Belongs to the cytochrome P450 family. (430 aa)
Cyp3a62Cytochrome P450, family 3, subfamily a, polypeptide 62. (480 aa)
LOC100361492Cytochrome P450, family 2, subfamily c, polypeptide 55-like; Belongs to the cytochrome P450 family. (488 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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