STRINGSTRING
Pla2g4c Pla2g4c Pnpla6 Pnpla6 Fasn Fasn Pla2g4b Pla2g4b Pla2g6 Pla2g6 Pla2g4a Pla2g4a Pla2g4d Pla2g4d Pnpla8 Pnpla8 Pnpla1 Pnpla1 Pnpla4 Pnpla4 Pnpla5 Pnpla5 Pla2g4e Pla2g4e Pnpla2 Pnpla2 Pnpla3 Pnpla3 Mcat Mcat Pnpla7 Pnpla7 Pla2g4f Pla2g4f
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pla2g4cPhospholipase A2 group IVC. (604 aa)
Pnpla6Patatin-like phospholipase domain-containing 6. (1354 aa)
Fasn3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2505 aa)
Pla2g4bPhospholipase A2. (791 aa)
Pla2g685/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide- induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose- stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2- induced chemotaxis through regulation of F-actin polymerization at the pseudopods (By [...] (807 aa)
Pla2g4aCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (752 aa)
Pla2g4dPhospholipase A2. (825 aa)
Pnpla8Patatin-like phospholipase domain-containing 8. (776 aa)
Pnpla1Patatin-like phospholipase domain-containing 1. (589 aa)
Pnpla4Patatin-like phospholipase domain-containing 4. (252 aa)
Pnpla5Patatin-like phospholipase domain containing 5 (Predicted). (453 aa)
Pla2g4ePhospholipase A2. (828 aa)
Pnpla2Patatin-like phospholipase domain-containing protein 2; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. (478 aa)
Pnpla3Patatin-like phospholipase domain-containing 3. (425 aa)
McatMalonyl-CoA-acyl carrier protein transacylase. (380 aa)
Pnpla7Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. (1349 aa)
Pla2g4fPhospholipase A2. (733 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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