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Fdxr Fdxr Pcyox1l Pcyox1l Il4i1 Il4i1 Rnls Rnls Smox Smox Pdpr Pdpr Fmo9 Fmo9 Maob Maob Gpd2 Gpd2 Fmo1 Fmo1 Aifm3 Aifm3 Mto1 Mto1 LOC685351 LOC685351 Fmo13 Fmo13 Sqor Sqor RGD1308564 RGD1308564 Paox Paox Maoa Maoa Fmo6 Fmo6 Gsr Gsr Gdi1 Gdi1 Foxred1 Foxred1 Aifm2 Aifm2 Txnrd3 Txnrd3 Mical3 Mical3 Dpyd Dpyd Mical2 Mical2 Dmgdh Dmgdh Gdi2 Gdi2 Chdh Chdh Pyroxd2 Pyroxd2 Osgin1 Osgin1 Retsat Retsat Sdha Sdha Pyroxd1 Pyroxd1 Coq6 Coq6 Txnrd1 Txnrd1 Etfdh Etfdh Pcyox1 Pcyox1 Kdm1b Kdm1b Sqle Sqle Osgin2 Osgin2 Pipox Pipox Sardh Sardh Lao1 Lao1 Dld Dld Aifm1 Aifm1 Foxred2 Foxred2 L2hgdh L2hgdh Kmo Kmo Ppox Ppox Fmo3 Fmo3 Fmo2 Fmo2 Fmo4 Fmo4 Txnrd2 Txnrd2 Mical1 Mical1 Chm Chm Fmo5 Fmo5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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FdxrNADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. (494 aa)
Pcyox1lPrenylcysteine oxidase 1-like. (494 aa)
Il4i1Amine oxidase. (648 aa)
RnlsRenalase; Catalyzes the oxidation of the less abundant 1,2-dihydro- beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+) (By similarity). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and [...] (315 aa)
SmoxRCG27151, isoform CRA_a. (555 aa)
PdprSimilar to pyruvate dehydrogenase phosphatase regulatory subunit (Predicted). (878 aa)
Fmo9Dimethylaniline monooxygenase [N-oxide-forming]. (543 aa)
MaobAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. (520 aa)
Gpd2Glycerol-3-phosphate dehydrogenase, mitochondrial. (726 aa)
Fmo1Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. (532 aa)
Aifm3Apoptosis-inducing factor, mitochondria-associated 3. (604 aa)
Mto1Mitochondrial tRNA translation optimization 1. (661 aa)
LOC685351Dimethylaniline monooxygenase [N-oxide-forming]. (538 aa)
Fmo13Dimethylaniline monooxygenase [N-oxide-forming]. (536 aa)
SqorSulfide quinone reductase-like (Yeast), isoform CRA_a. (450 aa)
RGD1308564Amine oxidase. (536 aa)
PaoxRCG47968, isoform CRA_a. (531 aa)
MaoaAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. (526 aa)
Fmo6Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
GsrGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (417 aa)
Gdi1Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. (447 aa)
Foxred1FAD-dependent oxidoreductase domain containing 1. (487 aa)
Aifm2Apoptosis-inducing factor, mitochondria-associated 2. (373 aa)
Txnrd3Thioredoxin reductase 3. (651 aa)
Mical3Microtubule-associated monooxygenase, calponin and LIM domain-containing 3. (1997 aa)
DpydDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). (948 aa)
Mical2[F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the n [...] (1103 aa)
DmgdhDimethylglycine dehydrogenase, mitochondrial; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. Belongs to the GcvT family. (884 aa)
Gdi2Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (445 aa)
ChdhCholine dehydrogenase, mitochondrial; Belongs to the GMC oxidoreductase family. (599 aa)
Pyroxd2Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase. (581 aa)
Osgin1Pregnancy-induced growth inhibitor, isoform CRA_a. (478 aa)
RetsatAll-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. (609 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (656 aa)
Pyroxd1Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity). (498 aa)
Coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6; Belongs to the UbiH/COQ6 family. (476 aa)
Txnrd1Thioredoxin reductase 1, cytoplasmic. (498 aa)
EtfdhElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family. (616 aa)
Pcyox1Prenylcysteine oxidase; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity). (504 aa)
Kdm1bAmine oxidase, flavin containing 1 (Predicted). (824 aa)
SqleSqualene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. (573 aa)
Osgin2Similar to Protein C8orf1 (HT41) (Predicted), isoform CRA_b. (550 aa)
PipoxPipecolic acid and sarcosine oxidase. (390 aa)
SardhSarcosine dehydrogenase, mitochondrial. (919 aa)
Lao1Amine oxidase. (519 aa)
DldDihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] (509 aa)
Aifm1Apoptosis-inducing factor 1, mitochondrial; Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (By similarity). Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and [...] (612 aa)
Foxred2FAD-dependent oxidoreductase domain-containing 2. (665 aa)
L2hgdhL-2-hydroxyglutarate dehydrogenase (Predicted). (463 aa)
KmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (478 aa)
PpoxProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (477 aa)
Fmo3Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] (531 aa)
Fmo2Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (535 aa)
Fmo4Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (560 aa)
Txnrd2Thioredoxin reductase 2, mitochondrial; Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains mitochondrial thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. (525 aa)
Mical1[F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation [...] (1047 aa)
ChmRab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] (647 aa)
Fmo5Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. (533 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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