| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Arsb | Galns | ENSRNOP00000014860 | ENSRNOP00000019528 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | N-acetylgalactosamine-6-sulfatase. | 0.515 |
| Arsb | Gusb | ENSRNOP00000014860 | ENSRNOP00000045033 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | 0.696 |
| Arsb | Hyal1 | ENSRNOP00000014860 | ENSRNOP00000021408 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | 0.931 |
| Arsb | Hyal2 | ENSRNOP00000014860 | ENSRNOP00000075204 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family. | 0.917 |
| Arsb | Hyal3 | ENSRNOP00000014860 | ENSRNOP00000021590 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro [...] | 0.903 |
| Arsb | Hyal4 | ENSRNOP00000014860 | ENSRNOP00000072978 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase. | 0.911 |
| Arsb | Hyal5 | ENSRNOP00000014860 | ENSRNOP00000057222 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase. | 0.914 |
| Arsb | Hyal6 | ENSRNOP00000014860 | ENSRNOP00000009405 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase. | 0.908 |
| Arsb | Idua | ENSRNOP00000014860 | ENSRNOP00000000048 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Alpha-L-iduronidase. | 0.969 |
| Arsb | LOC100909505 | ENSRNOP00000014860 | ENSRNOP00000006566 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.497 |
| Arsb | Naglu | ENSRNOP00000014860 | ENSRNOP00000051302 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | N-acetyl-alpha-glucosaminidase. | 0.608 |
| Arsb | Sgsh | ENSRNOP00000014860 | ENSRNOP00000065414 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Uncharacterized protein. | 0.599 |
| Arsb | Spam1 | ENSRNOP00000014860 | ENSRNOP00000009537 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity). | 0.908 |
| Galns | Arsb | ENSRNOP00000019528 | ENSRNOP00000014860 | N-acetylgalactosamine-6-sulfatase. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | 0.515 |
| Galns | Glb1 | ENSRNOP00000019528 | ENSRNOP00000013632 | N-acetylgalactosamine-6-sulfatase. | Beta-galactosidase. | 0.971 |
| Galns | Gusb | ENSRNOP00000019528 | ENSRNOP00000045033 | N-acetylgalactosamine-6-sulfatase. | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | 0.679 |
| Galns | Idua | ENSRNOP00000019528 | ENSRNOP00000000048 | N-acetylgalactosamine-6-sulfatase. | Alpha-L-iduronidase. | 0.588 |
| Galns | LOC100909505 | ENSRNOP00000019528 | ENSRNOP00000006566 | N-acetylgalactosamine-6-sulfatase. | N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.481 |
| Galns | Naglu | ENSRNOP00000019528 | ENSRNOP00000051302 | N-acetylgalactosamine-6-sulfatase. | N-acetyl-alpha-glucosaminidase. | 0.623 |
| Galns | Sgsh | ENSRNOP00000019528 | ENSRNOP00000065414 | N-acetylgalactosamine-6-sulfatase. | Uncharacterized protein. | 0.675 |