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Idua Idua Hpse Hpse LOC100909505 LOC100909505 Hyal6 Hyal6 Spam1 Spam1 Glb1 Glb1 Hexa Hexa Arsb Arsb Galns Galns Hyal1 Hyal1 Hyal3 Hyal3 Gusb Gusb Naglu Naglu Hyal5 Hyal5 Hpse2 Hpse2 Sgsh Sgsh Hyal4 Hyal4 Hyal2 Hyal2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IduaAlpha-L-iduronidase. (643 aa)
HpseHeparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially [...] (535 aa)
LOC100909505N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (544 aa)
Hyal6Hyaluronidase. (481 aa)
Spam1Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity). (512 aa)
Glb1Beta-galactosidase. (647 aa)
HexaBeta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (528 aa)
ArsbArylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). (528 aa)
GalnsN-acetylgalactosamine-6-sulfatase. (524 aa)
Hyal1Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. (449 aa)
Hyal3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro [...] (412 aa)
GusbBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (808 aa)
NagluN-acetyl-alpha-glucosaminidase. (739 aa)
Hyal5Hyaluronidase. (526 aa)
Hpse2Uncharacterized protein. (152 aa)
SgshUncharacterized protein. (306 aa)
Hyal4Hyaluronidase. (481 aa)
Hyal2Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family. (473 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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