STRINGSTRING
ESE81392.1 ESE81392.1 ppc ppc ESE87547.1 ESE87547.1 ESE87548.1 ESE87548.1 ESE87555.1 ESE87555.1 prpD prpD ESE87616.1 ESE87616.1 ESE87617.1 ESE87617.1 nuoN nuoN ESE87381.1 ESE87381.1 ESE87382.1 ESE87382.1 nuoK nuoK nuoI nuoI nuoH nuoH ESE87387.1 ESE87387.1 mdh mdh ESE85195.1 ESE85195.1 ESE85198.1 ESE85198.1 ESE84696.1 ESE84696.1 ESE84523.1 ESE84523.1 aceK aceK ESE83870.1 ESE83870.1 ESE82807.1 ESE82807.1 ubiE ubiE gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA ESE82165.1 ESE82165.1 sucC sucC sucD sucD ESE82184.1 ESE82184.1 ESE82185.1 ESE82185.1 ESE82186.1 ESE82186.1 fumC fumC ESE81606.1 ESE81606.1 ESE81607.1 ESE81607.1 ESE81608.1 ESE81608.1 aspA aspA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESE81392.1COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (883 aa)
ESE87547.1COG1271 Cytochrome bd-type quinol oxidase, subunit 1. (467 aa)
ESE87548.1COG1294 Cytochrome bd-type quinol oxidase, subunit 2. (336 aa)
ESE87555.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (389 aa)
prpD2-methylcitrate dehydratase; COG2079 Uncharacterized protein involved in propionate catabolism. (483 aa)
ESE87616.1COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3. (204 aa)
ESE87617.1COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Belongs to the heme-copper respiratory oxidase family. (663 aa)
nuoNNADH:ubiquinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (485 aa)
ESE87381.1COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M). (509 aa)
ESE87382.1COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit. (613 aa)
nuoKNADH:ubiquinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoINADH dehydrogenase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoHNADH:ubiquinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (325 aa)
ESE87387.1NADH dehydrogenase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (908 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
ESE85195.1COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I). (180 aa)
ESE85198.1COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit. (608 aa)
ESE84696.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
ESE84523.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; COG1049 Aconitase B; Belongs to the aconitase/IPM isomerase family. (865 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (581 aa)
ESE83870.1COG2225 Malate synthase; Belongs to the malate synthase family. (533 aa)
ESE82807.1COG0538 Isocitrate dehydrogenases. (416 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (427 aa)
sdhCCOG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (129 aa)
sdhDSuccinate dehydrogenase cytochrome b556 small membrane subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucACOG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (933 aa)
ESE82165.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
ESE82184.1COG1271 Cytochrome bd-type quinol oxidase, subunit 1. (522 aa)
ESE82185.1COG1294 Cytochrome bd-type quinol oxidase, subunit 2. (379 aa)
ESE82186.1Cyd operon protein YbgT; COG4890 Predicted outer membrane lipoprotein. (37 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
ESE81606.1Hypothetical protein. (29 aa)
ESE81607.1COG1294 Cytochrome bd-type quinol oxidase, subunit 2. (378 aa)
ESE81608.1COG1271 Cytochrome bd-type quinol oxidase, subunit 1. (514 aa)
aspACOG1027 Aspartate ammonia-lyase. (478 aa)
Your Current Organism:
Salmonella enterica indica
NCBI taxonomy Id: 1173950
Other names: S. enterica subsp. indica serovar 6,14,25:z10:1,(2),7 str. 1121, Salmonella enterica subsp. indica serovar 6,14,25:z10:1,(2),7 str. 1121
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