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AGS66930.1 AGS66930.1 AGS67146.1 AGS67146.1 AGS67312.1 AGS67312.1 AGS67677.1 AGS67677.1 hisG hisG hisE hisE aroB aroB aroK aroK aroC aroC aroE aroE AGS68417.1 AGS68417.1 argH argH argR argR argD argD argB argB argJ argJ argC argC AGS68464.1 AGS68464.1 AGS68576.1 AGS68576.1 AGS68650.1 AGS68650.1 AGS68756.1 AGS68756.1 dapA dapA dapD dapD aroQ aroQ AGS68929.1 AGS68929.1 trpA trpA trpB trpB trpC trpC trpE trpE hisI hisI AGS68968.1 AGS68968.1 AGS68969.1 AGS68969.1 hisF hisF AGS68971.1 AGS68971.1 priA-2 priA-2 hisH hisH AGS68974.1 AGS68974.1 hisB hisB hisC hisC hisD hisD AGS68978.1 AGS68978.1 AGS68979.1 AGS68979.1 AGS68980.1 AGS68980.1 AGS68981.1 AGS68981.1 AGS69043.1 AGS69043.1 AGS69044.1 AGS69044.1 trpD1 trpD1 asd asd AGS69739.1 AGS69739.1 AGS70574.1 AGS70574.1 pat pat AGS70674.1 AGS70674.1 lysY lysY AGS70808.1 AGS70808.1 AGS70849.1 AGS70849.1 asd-2 asd-2 AGS70902.1 AGS70902.1 AGS71302.1 AGS71302.1 AGS71552.1 AGS71552.1 AGS71553.1 AGS71553.1 trpD2 trpD2 AGS71571.1 AGS71571.1 AGS71639.1 AGS71639.1 AGS71642.1 AGS71642.1 AGS71719.1 AGS71719.1 aroA aroA lysA lysA aguA aguA dapB dapB dapA-2 dapA-2 dapF dapF arcA arcA AGS72360.1 AGS72360.1 AGS72398.1 AGS72398.1 AGS72424.1 AGS72424.1 argG argG AGS73087.1 AGS73087.1 AGS73548.1 AGS73548.1 AGS73549.1 AGS73549.1 AGS73550.1 AGS73550.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AGS66930.1Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (434 aa)
AGS67146.1COG0165 Argininosuccinate lyase. (539 aa)
AGS67312.1Amino acid decarboxylase; COG1982 Arginine/lysine/ornithine decarboxylases. (492 aa)
AGS67677.1COG1748 Saccharopine dehydrogenase and related proteins. (406 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
hisECOG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (90 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
aroECOG0169 Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (267 aa)
AGS68417.1COG0147 Anthranilate/para-aminobenzoate synthases component I. (365 aa)
argHCOG0165 Argininosuccinate lyase. (477 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (181 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa)
AGS68464.1Hypothetical protein. (147 aa)
AGS68576.1Orn/DAP/Arg decarboxylase 2; COG0019 Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (450 aa)
AGS68650.1COG0287 Prephenate dehydrogenase. (361 aa)
AGS68756.1Hypothetical protein; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (363 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
dapDTransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (328 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
AGS68929.1COG1605 Chorismate mutase. (116 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa)
trpCCOG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (498 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (133 aa)
AGS68968.1Integral membrane efflux protein; COG0477 Permeases of the major facilitator superfamily. (417 aa)
AGS68969.1COG0640 Predicted transcriptional regulators. (195 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
AGS68971.1Hypothetical protein; COG0251 Putative translation initiation inhibitor, yjgF family. (133 aa)
priA-2Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (241 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa)
AGS68974.1Hypothetical protein. (54 aa)
hisBCOG0131 Imidazoleglycerol-phosphate dehydratase. (200 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa)
hisDBifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
AGS68978.1Hypothetical protein. (525 aa)
AGS68979.1Hypothetical protein. (349 aa)
AGS68980.1COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease. (246 aa)
AGS68981.1Transcriptional regulator; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (166 aa)
AGS69043.1Phospho-2-dehydro-3-deoxyheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (416 aa)
AGS69044.1COG0147 Anthranilate/para-aminobenzoate synthases component I. (618 aa)
trpD1Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
AGS69739.1Agmatinase; COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (322 aa)
AGS70574.1COG0077 Prephenate dehydratase. (294 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
AGS70674.1COG0512 Anthranilate/para-aminobenzoate synthases component II. (212 aa)
lysYPutative LysW-gamma-L-alpha-aminoadipyl-6-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (355 aa)
AGS70808.1Aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (391 aa)
AGS70849.1COG0527 Aspartokinases; Belongs to the aspartokinase family. (423 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (360 aa)
AGS70902.1Morphological differentiation-associated protein; COG0560 Phosphoserine phosphatase. (268 aa)
AGS71302.1Hypothetical protein; COG1605 Chorismate mutase. (89 aa)
AGS71552.1COG0147 Anthranilate/para-aminobenzoate synthases component I. (504 aa)
AGS71553.1Glutamine amidotransferase of anthranilate synthase; COG0512 Anthranilate/para-aminobenzoate synthases component II. (195 aa)
trpD2Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (358 aa)
AGS71571.1COG0078 Ornithine carbamoyltransferase. (322 aa)
AGS71639.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (365 aa)
AGS71642.1COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (359 aa)
AGS71719.1COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (266 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
aguACOG2957 Peptidylarginine deiminase and related enzymes. (346 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
arcACOG2235 Arginine deiminase. (407 aa)
AGS72360.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (335 aa)
AGS72398.1COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
AGS72424.1COG0019 Diaminopimelate decarboxylase. (398 aa)
argGCOG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (482 aa)
AGS73087.1COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (341 aa)
AGS73548.1COG0165 Argininosuccinate lyase. (539 aa)
AGS73549.1GHMP kinase; COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase. (327 aa)
AGS73550.1COG0031 Cysteine synthase. (757 aa)
Your Current Organism:
Streptomyces collinus
NCBI taxonomy Id: 1214242
Other names: S. collinus Tu 365, Streptomyces collinus Tu 365
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