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| | aroK | COG1685 Archaeal shikimate kinase. (290 aa) |
| | C495_00815 | COG1605 Chorismate mutase. (106 aa) |
| | C495_00925 | COG0174 Glutamine synthetase. (451 aa) |
| | C495_01410 | COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (328 aa) |
| | C495_01565 | Glycine dehydrogenase subunit 1; COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain. (424 aa) |
| | C495_01570 | Glycine dehydrogenase subunit 2; COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain. (492 aa) |
| | C495_02135 | (R)-citramalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (510 aa) |
| | C495_02605 | COG0620 Methionine synthase II (cobalamin-independent). (358 aa) |
| | C495_02610 | Cobalamin-independent synthase MetE domain-containing protein; COG0620 Methionine synthase II (cobalamin-independent). (332 aa) |
| | C495_02730 | Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (366 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | C495_03147 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (426 aa) |
| | C495_03167 | COG1171 Threonine dehydratase. (416 aa) |
| | C495_03177 | Class III aminotransferase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | C495_03207 | Acetylornithine transaminase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa) |
| | C495_03212 | COG0506 Proline dehydrogenase. (282 aa) |
| | C495_03227 | COG0498 Threonine synthase. (397 aa) |
| | C495_03462 | CoA-disulfide reductase; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. (471 aa) |
| | C495_03887 | COG0473 Isocitrate/isopropylmalate dehydrogenase. (326 aa) |
| | C495_03902 | COG0066 3-isopropylmalate dehydratase small subunit. (243 aa) |
| | C495_03907 | COG0065 3-isopropylmalate dehydratase large subunit. (473 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa) |
| | C495_03922 | COG0440 Acetolactate synthase, small (regulatory) subunit. (223 aa) |
| | C495_03927 | Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (605 aa) |
| | C495_03932 | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (346 aa) |
| | C495_04312 | Spermine synthase; COG4262 Predicted spermidine synthase with an N-terminal membrane domain. (551 aa) |
| | C495_04397 | COG0174 Glutamine synthetase. (451 aa) |
| | C495_04532 | COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase. (297 aa) |
| | C495_04672 | COG0460 Homoserine dehydrogenase. (315 aa) |
| | C495_04877 | COG0067 Glutamate synthase domain 1. (1485 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (383 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa) |
| | C495_05427 | COG0547 Anthranilate phosphoribosyltransferase. (356 aa) |
| | C495_06223 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (419 aa) |
| | C495_06228 | COG0078 Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (309 aa) |
| | lysK-2 | Acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (356 aa) |
| | lysJ | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (383 aa) |
| | lysZ | Acetylglutamate/acetylaminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (283 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (348 aa) |
| | C495_06253 | Lysine biosynthesis protein LysX; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (295 aa) |
| | C495_06258 | Lysine biosynthesis protein LysW. (54 aa) |
| | argH | COG0165 Argininosuccinate lyase. (434 aa) |
| | argG | COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (398 aa) |
| | ahcY | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (429 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (288 aa) |
| | ala | Ornithine cyclodeaminase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (330 aa) |
| | C495_07068 | COG0077 Prephenate dehydratase. (270 aa) |
| | C495_07333 | COG1045 Serine acetyltransferase. (169 aa) |
| | C495_07590 | COG0527 Aspartokinases; Belongs to the aspartokinase family. (392 aa) |
| | tnaA | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; COG3033 Tryptophanase. (448 aa) |
| | C495_07785 | COG2873 O-acetylhomoserine sulfhydrylase. (447 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (403 aa) |
| | C495_07805 | COG0560 Phosphoserine phosphatase. (218 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (123 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (245 aa) |
| | hisB | COG0131 Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisE | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (94 aa) |
| | C495_08625 | Peptidase M20; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (366 aa) |
| | C495_08745 | FAD dependent oxidoreductase; COG0665 Glycine/D-amino acid oxidases (deaminating). (521 aa) |
| | C495_08915 | COG1387 Histidinol phosphatase and related hydrolases of the PHP family. (260 aa) |
| | C495_09060 | Folate-binding protein YgfZ; COG0404 Glycine cleavage system T protein (aminomethyltransferase). (365 aa) |
| | C495_09115 | Class III aminotransferase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa) |
| | solA | COG0665 Glycine/D-amino acid oxidases (deaminating). (376 aa) |
| | C495_09275 | Pyruvoyl-dependent arginine decarboxylase. (159 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa) |
| | C495_09809 | Agmatinase; COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (304 aa) |
| | C495_09944 | COG2873 O-acetylhomoserine sulfhydrylase. (429 aa) |
| | C495_10544 | COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (387 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (311 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | dapD | COG2171 Tetrahydrodipicolinate N-succinyltransferase. (278 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (255 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (309 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (361 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (226 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (333 aa) |
| | trpB-2 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (421 aa) |
| | trpC | COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa) |
| | katG | Catalase/hydroperoxidase HPI(I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (714 aa) |
| | C495_11664 | COG0436 Aspartate/tyrosine/aromatic aminotransferase. (382 aa) |
| | C495_12210 | Nitrilase; COG0388 Predicted amidohydrolase. (361 aa) |
| | C495_12505 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa) |
| | C495_12520 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa) |
| | C495_12545 | COG1012 NAD-dependent aldehyde dehydrogenases. (511 aa) |
| | C495_12614 | FAD dependent oxidoreductase; COG0665 Glycine/D-amino acid oxidases (deaminating). (394 aa) |
| | C495_12914 | Aminodeoxychorismate lyase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (296 aa) |
| | C495_12919 | Glutamine amidotransferase of anthranilate synthase; COG0512 Anthranilate/para-aminobenzoate synthases component II. (224 aa) |
| | C495_12924 | COG0147 Anthranilate/para-aminobenzoate synthases component I. (550 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | C495_13386 | COG0287 Prephenate dehydrogenase. (268 aa) |
| | C495_13616 | COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog. (329 aa) |
| | C495_14077 | COG0031 Cysteine synthase. (207 aa) |
| | C495_14147 | Acetylornithine transaminase; COG0160 4-aminobutyrate aminotransferase and related aminotransferases. (287 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | gcvT | Glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (373 aa) |
| | C495_14492 | Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (373 aa) |
| | C495_14542 | Thiamine pyrophosphate domain-containing TPP-binding protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (563 aa) |
| | hisC | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (379 aa) |
| | C495_14952 | COG0136 Aspartate-semialdehyde dehydrogenase. (344 aa) |
| | hisD | Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | C495_15002 | Serine--pyruvate transaminase; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. (401 aa) |
| | cysS | COG0215 Cysteinyl-tRNA synthetase. (497 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | ilvD | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (578 aa) |
| | C495_15943 | Glutamine amidotransferase of anthranilate synthase; COG0512 Anthranilate/para-aminobenzoate synthases component II. (214 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (558 aa) |
| | trpF | COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (222 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (247 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (279 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (443 aa) |
