STRINGSTRING
C495_01790 C495_01790 priS priS C495_02000 C495_02000 C495_02635 C495_02635 C495_02685 C495_02685 nusG nusG C495_03717 C495_03717 C495_03822 C495_03822 C495_04267 C495_04267 C495_05107 C495_05107 C495_05497 C495_05497 cca cca C495_06193 C495_06193 C495_06213 C495_06213 radA radA pcn pcn priL priL C495_07033 C495_07033 polC polC C495_07238 C495_07238 C495_07480 C495_07480 polB polB rfc rfc spt4 spt4 C495_09200 C495_09200 C495_09690 C495_09690 tmk tmk rnhB rnhB C495_10964 C495_10964 fen fen C495_12510 C495_12510 topA topA mre11 mre11 rad50 rad50 C495_13466 C495_13466 C495_14102 C495_14102 thyA thyA rfcL rfcL C495_14557 C495_14557 C495_14622 C495_14622 lig lig C495_15117 C495_15117 dbh dbh C495_15933 C495_15933 radB radB C495_16330 C495_16330 C495_16825 C495_16825 C495_17207 C495_17207
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
C495_01790COG0328 Ribonuclease HI. (197 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (391 aa)
C495_02000Cell division control protein 6-like protein; Involved in regulation of DNA replication. (398 aa)
C495_02635COG1491 Predicted RNA-binding protein. (198 aa)
C495_02685Hypothetical protein; Involved in DNA damage repair. (433 aa)
nusGTranscription antitermination protein NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (145 aa)
C495_03717Hypothetical protein; COG1948 ERCC4-type nuclease. (147 aa)
C495_03822DNA-directed DNA polymerase type II; COG0417 DNA polymerase elongation subunit (family B). (818 aa)
C495_04267COG0012 Predicted GTPase, probable translation factor. (399 aa)
C495_05107Cell division control protein 6-like protein; Involved in regulation of DNA replication. (399 aa)
C495_05497Replication factor A; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins. (477 aa)
ccatRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (467 aa)
C495_06193Hypothetical protein; COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family. (1260 aa)
C495_06213Cell division control protein 21; COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family; Belongs to the MCM family. (1172 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (343 aa)
pcnDNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (359 aa)
C495_07033Thermosome; COG0459 Chaperonin GroEL (HSP60 family); Belongs to the TCP-1 chaperonin family. (557 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1719 aa)
C495_07238Hef nuclease; COG1111 ERCC4-like helicases. (811 aa)
C495_07480Cell division control protein 6-like protein; Involved in regulation of DNA replication. (532 aa)
polBDNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (518 aa)
rfcReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (329 aa)
spt4DNA-directed RNA polymerase subunit E, RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (65 aa)
C495_09200Deoxyuridine 5'-triphosphate nucleotidohydrolase; COG0717 Deoxycytidine deaminase. (160 aa)
C495_09690Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (410 aa)
tmkCOG0125 Thymidylate kinase. (200 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (219 aa)
C495_10964Cell division control protein 6; Involved in regulation of DNA replication. (395 aa)
fenFlap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (325 aa)
C495_12510Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (427 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (828 aa)
mre11Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. (442 aa)
rad50Chromosome segregation protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily. (892 aa)
C495_13466COG0417 DNA polymerase elongation subunit (family B). (1321 aa)
C495_14102COG0262 Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (177 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (338 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (494 aa)
C495_14557COG0012 Predicted GTPase, probable translation factor. (392 aa)
C495_14622Orc1/cdc6 family replication initiation protein; COG1474 Cdc6-related protein, AAA superfamily ATPase. (337 aa)
ligATP-dependent DNA ligase I; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (563 aa)
C495_15117Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (412 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (423 aa)
C495_15933Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1037 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (235 aa)
C495_16330Cell division control protein 6; Involved in regulation of DNA replication. (418 aa)
C495_16825Cell division control protein 6; Involved in regulation of DNA replication. (409 aa)
C495_17207ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (419 aa)
Your Current Organism:
Natronorubrum sulfidifaciens
NCBI taxonomy Id: 1230460
Other names: N. sulfidifaciens JCM 14089, Natronorubrum sp. AD2, Natronorubrum sulfidifaciens AD2, Natronorubrum sulfidifaciens JCM 14089
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