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KXI14858.1 KXI14858.1 rpmE rpmE KXI14478.1 KXI14478.1 rplS rplS gltX gltX rpsB rpsB tsf tsf rplT rplT rpmI rpmI map map selB selB rpmF rpmF rpmB rpmB rpmA rpmA rplU rplU rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN1 rpsN1 rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO secY secY KXI13120.1 KXI13120.1 infA infA rpmJ rpmJ rpsM rpsM rpsK rpsK rplQ rplQ rpmH rpmH rpsF rpsF rpsR rpsR rplI rplI rpsI rpsI rplM rplM rpmG2 rpmG2 rplK rplK rplA rplA rplJ rplJ rplL rplL rpsT rpsT rpsP rpsP tuf tuf fusA fusA rpsG rpsG rpsL rpsL KXI11054.1 KXI11054.1 rpsO rpsO KXI10930.1 KXI10930.1 rpsD rpsD rpsU rpsU
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KXI14858.1S1 RNA binding domain protein; KEGG: fma:FMG_0826 1.2e-54 fused penicillin tolerance LytB domain-containing protein/30S ribosomal protein S1; K02945 small subunit ribosomal protein S1; K03527 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Psort location: Cytoplasmic, score: 9.97. (432 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (66 aa)
KXI14478.1KEGG: acl:ACL_0298 1.1e-131 fusA; translation elongation factor EF-G K02355; Psort location: Cytoplasmic, score: 9.97. (642 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (124 aa)
gltXglutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (547 aa)
rpsBRibosomal protein S2; KEGG: apb:SAR116_0519 1.1e-60 30S ribosomal protein S2 K02967; Psort location: Cytoplasmic, score: 9.97; Belongs to the universal ribosomal protein uS2 family. (259 aa)
tsfTranslation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (302 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
rpmIRibosomal protein L35; Psort location: Cytoplasmic, score: 9.67; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
mapMethionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (288 aa)
selBKEGG: clj:CLJU_c07480 9.4e-149 selenocysteine-specific translation elongation factor; Psort location: Cytoplasmic, score: 9.97. (629 aa)
rpmFRibosomal protein L32; KEGG: apb:SAR116_0011 5.9e-05 50S ribosomal protein L32 K02911; Psort location: Cytoplasmic, score: 9.67; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
rpmBRibosomal protein L28; KEGG: apb:SAR116_1905 0.0023 50S ribosomal protein L28 K02902; Psort location: Cytoplasmic, score: 9.67; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
rpmARibosomal protein L27; KEGG: apb:SAR116_1855 5.3e-20 50S ribosomal protein L27 K02899; Psort location: Cytoplasmic, score: 9.67; Belongs to the bacterial ribosomal protein bL27 family. (96 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (209 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (207 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (96 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplVRibosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (118 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (265 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (140 aa)
rpmCRibosomal protein L29; KEGG: apb:SAR116_2399 3.0e-10 50S ribosomal protein L29 K02904; Psort location: Cytoplasmic, score: 7.50; Belongs to the universal ribosomal protein uL29 family. (67 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (93 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (101 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rpsN1Ribosomal protein S14p/S29e; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (180 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (125 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (169 aa)
rpmDRibosomal protein L30; KEGG: apb:SAR116_2409 4.6e-05 50S ribosomal protein L30 K02907; Psort location: Cytoplasmic, score: 9.67. (61 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
secYPreprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (422 aa)
KXI13120.1KEGG: cbt:CLH_0474 0.0072 hemK; protein-(glutamine-N5) methyltransferase; K02493 release factor glutamine methyltransferase; Psort location: Cytoplasmic, score: 7.50. (89 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
rpmJRibosomal protein L36; Psort location: Cytoplasmic, score: 9.67; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (123 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (133 aa)
rplQRibosomal protein L17; KEGG: apb:SAR116_2416 1.9e-22 50S ribosomal protein L17 K02879; Psort location: Cytoplasmic, score: 9.97. (113 aa)
rpmHRibosomal protein L34; KEGG: rri:A1G_05155 1.0e-09 rpmH; 50S ribosomal protein L34 K02914; Psort location: Cytoplasmic, score: 9.67; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (82 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (148 aa)
rpsIRibosomal protein S9; KEGG: apb:SAR116_0492 1.6e-27 30S ribosomal protein S9 K02996; Psort location: Cytoplasmic, score: 9.67; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (164 aa)
rpmG2Ribosomal protein L33; KEGG: mmo:MMOB5490 5.0e-08 rpmG; 50S ribosomal protein L33 K02913; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (232 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (172 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (121 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
rpsPRibosomal protein S16; KEGG: apb:SAR116_1817 3.8e-17 30S ribosomal protein S16 K02959; Psort location: Cytoplasmic, score: 9.95; Belongs to the bacterial ribosomal protein bS16 family. (83 aa)
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (688 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLRibosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (140 aa)
KXI11054.1Putative translation elongation factor G; KEGG: efu:HMPREF0351_10054 3.6e-60 fusA; protein-synthesizing GTPase K02355; Psort location: Cytoplasmic, score: 9.97. (644 aa)
rpsORibosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (85 aa)
KXI10930.1Ribosomal protein L7Ae. (105 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa)
rpsURibosomal protein S21; KEGG: sew:SeSA_A3399 1.6e-11 rpsU; 30S ribosomal protein S21 K02970; Psort location: Cytoplasmic, score: 9.97; Belongs to the bacterial ribosomal protein bS21 family. (77 aa)
Your Current Organism:
Peptostreptococcus anaerobius
NCBI taxonomy Id: 1261
Other names: ATCC 27337, CCUG 7835, CIP 104411, DSM 2949, LMG 15865, LMG:15865, NCTC 11460, P. anaerobius, Streptococcus anaerob, Streptococcus anaerobius, VPI 4330
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