(9 nodes) Telomeric DNA binding network (Kwoniella bestiolae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I302_09130	Uncharacterized protein. (371 aa)
	I302_08576	Ku domain-containing protein. (850 aa)
	I302_08000	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1042 aa)
	I302_07389	Telomere_reg-2 domain-containing protein. (1105 aa)
	I302_07429	Ku domain-containing protein. (751 aa)
	I302_06949	Uncharacterized protein. (231 aa)
	I302_05736	DNA repair protein RAD50. (1357 aa)
	I302_06133	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (612 aa)
	I302_05123	PINc domain-containing protein. (1172 aa)

Your Current Organism:

Kwoniella bestiolae

NCBI taxonomy Id: 1296100
Other names: Cryptococcus bestiolae CBS 10118, Cryptococcus bestiolae CBS10118, K. bestiolae CBS 10118, Kwoniella bestiolae CBS 10118

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I302_05123	I302_07429	A0A1B9G2R1	A0A1B9FWE0	PINc domain-containing protein.	Ku domain-containing protein.	0.570
I302_05123	I302_08000	A0A1B9G2R1	A0A1B9FUA0	PINc domain-containing protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.825
I302_05123	I302_08576	A0A1B9G2R1	A0A1B9FSP5	PINc domain-containing protein.	Ku domain-containing protein.	0.599
I302_05736	I302_06133	A0A1B9FZS9	A0A1B9G0X3	DNA repair protein RAD50.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.859
I302_05736	I302_07429	A0A1B9FZS9	A0A1B9FWE0	DNA repair protein RAD50.	Ku domain-containing protein.	0.945
I302_05736	I302_08000	A0A1B9FZS9	A0A1B9FUA0	DNA repair protein RAD50.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.683
I302_05736	I302_08576	A0A1B9FZS9	A0A1B9FSP5	DNA repair protein RAD50.	Ku domain-containing protein.	0.848
I302_06133	I302_05736	A0A1B9G0X3	A0A1B9FZS9	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	DNA repair protein RAD50.	0.859
I302_06133	I302_07429	A0A1B9G0X3	A0A1B9FWE0	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	Ku domain-containing protein.	0.850
I302_06133	I302_08000	A0A1B9G0X3	A0A1B9FUA0	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.898
I302_06133	I302_08576	A0A1B9G0X3	A0A1B9FSP5	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	Ku domain-containing protein.	0.563
I302_06133	I302_09130	A0A1B9G0X3	A0A1B9FRR4	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	Uncharacterized protein.	0.433
I302_07429	I302_05123	A0A1B9FWE0	A0A1B9G2R1	Ku domain-containing protein.	PINc domain-containing protein.	0.570
I302_07429	I302_05736	A0A1B9FWE0	A0A1B9FZS9	Ku domain-containing protein.	DNA repair protein RAD50.	0.945
I302_07429	I302_06133	A0A1B9FWE0	A0A1B9G0X3	Ku domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.850
I302_07429	I302_08000	A0A1B9FWE0	A0A1B9FUA0	Ku domain-containing protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.864
I302_07429	I302_08576	A0A1B9FWE0	A0A1B9FSP5	Ku domain-containing protein.	Ku domain-containing protein.	0.999
I302_08000	I302_05123	A0A1B9FUA0	A0A1B9G2R1	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	PINc domain-containing protein.	0.825
I302_08000	I302_05736	A0A1B9FUA0	A0A1B9FZS9	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	DNA repair protein RAD50.	0.683
I302_08000	I302_06133	A0A1B9FUA0	A0A1B9G0X3	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.898