STRINGSTRING
AGP52065.1 AGP52065.1 glyA glyA AGP52170.1 AGP52170.1 AGP52379.1 AGP52379.1 AGP52657.1 AGP52657.1 AGP52658.1 AGP52658.1 AGP52738.1 AGP52738.1 AGP52860.1 AGP52860.1 AGP53073.1 AGP53073.1 pfkA pfkA AGP53452.1 AGP53452.1 AGP53999.1 AGP53999.1 AGP54131.1 AGP54131.1 AGP54327.1 AGP54327.1 fbiD fbiD AGP54801.1 AGP54801.1 glyA-2 glyA-2 pfkA-2 pfkA-2 AGP54934.1 AGP54934.1 ackA ackA glyA-3 glyA-3 glpX glpX ppc ppc fbiC fbiC AGP55731.1 AGP55731.1 AGP56265.1 AGP56265.1 AGP56358.1 AGP56358.1 AGP56558.1 AGP56558.1 pfp pfp acsA acsA gpmA gpmA serC serC mdh mdh glyA-4 glyA-4 eno eno fbiB fbiB fbiA fbiA AGP58244.1 AGP58244.1 pfp-2 pfp-2 AGP58855.1 AGP58855.1 AGP59025.1 AGP59025.1 fbiC-2 fbiC-2 fbiD-2 fbiD-2 AGP59710.1 AGP59710.1 AGP59865.1 AGP59865.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AGP52065.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (250 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa)
AGP52170.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
AGP52379.1Aldehyde-activating protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (179 aa)
AGP52657.1Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1087 aa)
AGP52658.1Ferredoxin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (342 aa)
AGP52738.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (537 aa)
AGP52860.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (279 aa)
AGP53073.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (421 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AGP53452.15,10-methylenetetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (347 aa)
AGP53999.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (568 aa)
AGP54131.1Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (649 aa)
AGP54327.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (565 aa)
fbiD2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (273 aa)
AGP54801.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AGP54934.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (708 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (381 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
glpXType II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (343 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (906 aa)
fbiCRadical SAM protein; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (870 aa)
AGP55731.1Molecular chaperone GroES; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (349 aa)
AGP56265.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
AGP56358.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (484 aa)
AGP56558.1Hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (210 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (667 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
glyA-4Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
fbiBF420-0--gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (483 aa)
fbiA2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (320 aa)
AGP58244.1Molecular chaperone GroES; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa)
pfp-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AGP58855.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (410 aa)
AGP59025.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (204 aa)
fbiC-2Radical SAM protein; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (836 aa)
fbiD-2Hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (220 aa)
AGP59710.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (356 aa)
AGP59865.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (312 aa)
Your Current Organism:
Streptomyces rapamycinicus
NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491
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