STRINGSTRING
SOS1 SOS1 K7EXK2_PELSI K7EXK2_PELSI SPRY3 SPRY3 FLRT3 FLRT3 FLRT1 FLRT1 FNDC3A FNDC3A FLRT2 FLRT2 MKNK1 MKNK1 UBC UBC PTPN11 PTPN11 NRAS NRAS CSDE1 CSDE1 GAB1 GAB1 FGF10 FGF10 ANOS1 ANOS1 PPP2CA PPP2CA LOC102447645 LOC102447645 SPRED1 SPRED1 K7FGG7_PELSI K7FGG7_PELSI FNDC3B FNDC3B K7FIQ5_PELSI K7FIQ5_PELSI K7FJ02_PELSI K7FJ02_PELSI FRS3 FRS3 FGF17 FGF17 FGF8 FGF8 FGF3 FGF3 SPRED2 SPRED2 FGF4 FGF4 GRB2 GRB2 FGFRL1 FGFRL1 SPRY2 SPRY2 UBA52 UBA52 FGF6 FGF6 FGF23 FGF23 BRAF BRAF FGF18 FGF18 FGF5 FGF5 FGF2 FGF2 K7FZH9_PELSI K7FZH9_PELSI FRS2 FRS2 MKNK2 MKNK2 KRAS KRAS HRAS HRAS FGF1 FGF1 PIK3CA PIK3CA RPS27A RPS27A LOC102443910 LOC102443910 K7G5M9_PELSI K7G5M9_PELSI PPP2CB PPP2CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
K7EXK2_PELSIUbiquitin-like domain-containing protein. (32 aa)
SPRY3Sprouty RTK signaling antagonist 3. (290 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (661 aa)
FNDC3AFibronectin type III domain containing 3A. (1142 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (661 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
UBCUncharacterized protein. (355 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (591 aa)
NRASNRAS proto-oncogene, GTPase. (123 aa)
CSDE1Cold shock domain containing E1. (471 aa)
GAB1GRB2 associated binding protein 1. (687 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ANOS1Anosmin 1. (678 aa)
PPP2CASerine/threonine-protein phosphatase. (244 aa)
LOC102447645Uncharacterized protein. (227 aa)
SPRED1Sprouty related EVH1 domain containing 1. (213 aa)
K7FGG7_PELSIUncharacterized protein. (738 aa)
FNDC3BFibronectin type III domain containing 3B. (1211 aa)
K7FIQ5_PELSIPI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (211 aa)
K7FJ02_PELSIPhosphatidylinositol 3-kinase catalytic subunit type 3. (787 aa)
FRS3Fibroblast growth factor receptor substrate 3; Belongs to the peptidase A1 family. (738 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
SPRED2Sprouty related EVH1 domain containing 2. (410 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FGFRL1Fibroblast growth factor receptor like 1. (487 aa)
SPRY2Sprouty RTK signaling antagonist 2. (313 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (250 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (760 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (204 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (97 aa)
K7FZH9_PELSIUncharacterized protein. (310 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (467 aa)
KRASKRAS proto-oncogene, GTPase. (227 aa)
HRASHRas proto-oncogene, GTPase. (190 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
RPS27AUbiquitin-like domain-containing protein. (140 aa)
LOC102443910Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
K7G5M9_PELSIUncharacterized protein. (120 aa)
PPP2CBSerine/threonine-protein phosphatase. (307 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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