STRINGSTRING
BRAF BRAF FGF8 FGF8 FGF9 FGF9 FGF17 FGF17 FRS3 FRS3 K7FJ02_PELSI K7FJ02_PELSI K7FIQ5_PELSI K7FIQ5_PELSI FNDC3B FNDC3B K7FGG7_PELSI K7FGG7_PELSI LOC102447645 LOC102447645 PPP2CA PPP2CA GAB1 GAB1 CSDE1 CSDE1 NRAS NRAS PTPN11 PTPN11 UBC UBC MKNK1 MKNK1 FNDC3A FNDC3A SPRY3 SPRY3 FGFR3 FGFR3 SPRY2 SPRY2 FGF20 FGF20 UBA52 UBA52 FGF23 FGF23 FGF4 FGF4 FGF18 FGF18 FGF2 FGF2 K7FZH9_PELSI K7FZH9_PELSI RPS27A RPS27A SOS1 SOS1 PPP2CB PPP2CB K7EXK2_PELSI K7EXK2_PELSI K7G5M9_PELSI K7G5M9_PELSI LOC102443910 LOC102443910 PIK3CA PIK3CA FGF1 FGF1 HRAS HRAS KRAS KRAS MKNK2 MKNK2 FRS2 FRS2 FGF16 FGF16 FGF5 FGF5 GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRAFB-Raf proto-oncogene, serine/threonine kinase. (760 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FRS3Fibroblast growth factor receptor substrate 3; Belongs to the peptidase A1 family. (738 aa)
K7FJ02_PELSIPhosphatidylinositol 3-kinase catalytic subunit type 3. (787 aa)
K7FIQ5_PELSIPI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (211 aa)
FNDC3BFibronectin type III domain containing 3B. (1211 aa)
K7FGG7_PELSIUncharacterized protein. (738 aa)
LOC102447645Uncharacterized protein. (227 aa)
PPP2CASerine/threonine-protein phosphatase. (244 aa)
GAB1GRB2 associated binding protein 1. (687 aa)
CSDE1Cold shock domain containing E1. (471 aa)
NRASNRAS proto-oncogene, GTPase. (123 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (591 aa)
UBCUncharacterized protein. (355 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
FNDC3AFibronectin type III domain containing 3A. (1142 aa)
SPRY3Sprouty RTK signaling antagonist 3. (290 aa)
FGFR3Fibroblast growth factor receptor. (827 aa)
SPRY2Sprouty RTK signaling antagonist 2. (313 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (250 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (204 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (97 aa)
K7FZH9_PELSIUncharacterized protein. (310 aa)
RPS27AUbiquitin-like domain-containing protein. (140 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
PPP2CBSerine/threonine-protein phosphatase. (307 aa)
K7EXK2_PELSIUbiquitin-like domain-containing protein. (32 aa)
K7G5M9_PELSIUncharacterized protein. (120 aa)
LOC102443910Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HRASHRas proto-oncogene, GTPase. (190 aa)
KRASKRAS proto-oncogene, GTPase. (227 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (467 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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