STRINGSTRING
U7PWP3_SPOS1 U7PWP3_SPOS1 U7PVY0_SPOS1 U7PVY0_SPOS1 LSM3 LSM3 U7PVL2_SPOS1 U7PVL2_SPOS1 U7PUL5_SPOS1 U7PUL5_SPOS1 U7PUB8_SPOS1 U7PUB8_SPOS1 U7PU94_SPOS1 U7PU94_SPOS1 U7PU07_SPOS1 U7PU07_SPOS1 TRM82 TRM82 U7PTC3_SPOS1 U7PTC3_SPOS1 U7PT78_SPOS1 U7PT78_SPOS1 U7PT16_SPOS1 U7PT16_SPOS1 U7PSJ9_SPOS1 U7PSJ9_SPOS1 U7PS44_SPOS1 U7PS44_SPOS1 U7PRY4_SPOS1 U7PRY4_SPOS1 U7PRT4_SPOS1 U7PRT4_SPOS1 U7PRI2_SPOS1 U7PRI2_SPOS1 U7PRH8_SPOS1 U7PRH8_SPOS1 U7PRD1_SPOS1 U7PRD1_SPOS1 U7PR86_SPOS1 U7PR86_SPOS1 U7PR18_SPOS1 U7PR18_SPOS1 U7PR15_SPOS1 U7PR15_SPOS1 U7PQY7_SPOS1 U7PQY7_SPOS1 U7PQI1_SPOS1 U7PQI1_SPOS1 U7PQ71_SPOS1 U7PQ71_SPOS1 U7PQ64_SPOS1 U7PQ64_SPOS1 U7PPQ5_SPOS1 U7PPQ5_SPOS1 U7PPJ2_SPOS1 U7PPJ2_SPOS1 U7PP09_SPOS1 U7PP09_SPOS1 LSM4 LSM4 U7PNY7_SPOS1 U7PNY7_SPOS1 U7PNW1_SPOS1 U7PNW1_SPOS1 U7PNV2_SPOS1 U7PNV2_SPOS1 U7PNR6_SPOS1 U7PNR6_SPOS1 U7PND8_SPOS1 U7PND8_SPOS1 U7PNB7_SPOS1 U7PNB7_SPOS1 U7PN02_SPOS1 U7PN02_SPOS1 U7PMY8_SPOS1 U7PMY8_SPOS1 U7PMP6_SPOS1 U7PMP6_SPOS1 U7PME3_SPOS1 U7PME3_SPOS1 U7PM08_SPOS1 U7PM08_SPOS1 U7PLQ3_SPOS1 U7PLQ3_SPOS1 U7PLF9_SPOS1 U7PLF9_SPOS1 uba4 uba4 U7PJT2_SPOS1 U7PJT2_SPOS1 U7PJS9_SPOS1 U7PJS9_SPOS1 URM1 URM1 U7PJC2_SPOS1 U7PJC2_SPOS1 U7PJA1_SPOS1 U7PJA1_SPOS1 U7PHZ6_SPOS1 U7PHZ6_SPOS1 U7PHE5_SPOS1 U7PHE5_SPOS1 U7Q8T1_SPOS1 U7Q8T1_SPOS1 U7Q838_SPOS1 U7Q838_SPOS1 U7Q7U7_SPOS1 U7Q7U7_SPOS1 U7Q7R0_SPOS1 U7Q7R0_SPOS1 U7Q7J7_SPOS1 U7Q7J7_SPOS1 U7Q7H2_SPOS1 U7Q7H2_SPOS1 U7Q6H7_SPOS1 U7Q6H7_SPOS1 U7Q6E1_SPOS1 U7Q6E1_SPOS1 U7Q6B1_SPOS1 U7Q6B1_SPOS1 U7Q6A3_SPOS1 U7Q6A3_SPOS1 U7Q5T0_SPOS1 U7Q5T0_SPOS1 U7Q5H8_SPOS1 U7Q5H8_SPOS1 U7Q5G3_SPOS1 U7Q5G3_SPOS1 TRM5 TRM5 KAE1 KAE1 ALA1 ALA1 U7Q555_SPOS1 U7Q555_SPOS1 U7Q4Y2_SPOS1 U7Q4Y2_SPOS1 U7Q4K7_SPOS1 U7Q4K7_SPOS1 U7Q4I1_SPOS1 U7Q4I1_SPOS1 LSM5 LSM5 U7Q4D7_SPOS1 U7Q4D7_SPOS1 U7Q493_SPOS1 U7Q493_SPOS1 NAT10 NAT10 U7Q3R8_SPOS1 U7Q3R8_SPOS1 U7Q3I6_SPOS1 U7Q3I6_SPOS1 U7Q367_SPOS1 U7Q367_SPOS1 U7Q340_SPOS1 U7Q340_SPOS1 U7Q2X1_SPOS1 U7Q2X1_SPOS1 U7Q2Q3_SPOS1 U7Q2Q3_SPOS1 U7Q2E5_SPOS1 U7Q2E5_SPOS1 U7Q274_SPOS1 U7Q274_SPOS1 U7Q1V8_SPOS1 U7Q1V8_SPOS1 U7Q1L3_SPOS1 U7Q1L3_SPOS1 U7Q1A8_SPOS1 U7Q1A8_SPOS1 U7Q166_SPOS1 U7Q166_SPOS1 AIM41 AIM41 U7Q127_SPOS1 U7Q127_SPOS1 U7Q109_SPOS1 U7Q109_SPOS1 U7Q0X4_SPOS1 U7Q0X4_SPOS1 U7Q0V7_SPOS1 U7Q0V7_SPOS1 U7Q0N1_SPOS1 U7Q0N1_SPOS1 U7Q0L7_SPOS1 U7Q0L7_SPOS1 U7Q0G9_SPOS1 U7Q0G9_SPOS1 U7Q0B3_SPOS1 U7Q0B3_SPOS1 U7PZT4_SPOS1 U7PZT4_SPOS1 U7PZS3_SPOS1 U7PZS3_SPOS1 TRM8 TRM8 U7PZD3_SPOS1 U7PZD3_SPOS1 U7PYR1_SPOS1 U7PYR1_SPOS1 U7PYN2_SPOS1 U7PYN2_SPOS1 U7PYD4_SPOS1 U7PYD4_SPOS1 U7PYD3_SPOS1 U7PYD3_SPOS1 U7PY83_SPOS1 U7PY83_SPOS1 U7PXW2_SPOS1 U7PXW2_SPOS1 U7PXS7_SPOS1 U7PXS7_SPOS1 U7PXD5_SPOS1 U7PXD5_SPOS1 NCS6 NCS6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
U7PWP3_SPOS1Uncharacterized protein. (217 aa)
U7PVY0_SPOS1DUF2428 domain-containing protein. (1586 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (92 aa)
U7PVL2_SPOS1tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. (787 aa)
U7PUL5_SPOS1Uncharacterized protein. (127 aa)
U7PUB8_SPOS1Uncharacterized protein. (356 aa)
U7PU94_SPOS1PPM-type phosphatase domain-containing protein. (650 aa)
U7PU07_SPOS1DPH-type MB domain-containing protein. (210 aa)
TRM82tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (588 aa)
U7PTC3_SPOS1Uncharacterized protein. (445 aa)
U7PT78_SPOS1Uncharacterized protein. (416 aa)
U7PT16_SPOS1Uncharacterized protein. (456 aa)
U7PSJ9_SPOS1Uncharacterized protein. (532 aa)
U7PS44_SPOS1TYW3 domain-containing protein. (377 aa)
U7PRY4_SPOS1Uncharacterized protein. (942 aa)
U7PRT4_SPOS1Sm domain-containing protein. (216 aa)
U7PRI2_SPOS1Uncharacterized protein. (561 aa)
U7PRH8_SPOS1Uncharacterized protein. (281 aa)
U7PRD1_SPOS1CMP/dCMP-type deaminase domain-containing protein. (494 aa)
U7PR86_SPOS1Uncharacterized protein. (1053 aa)
U7PR18_SPOS1Uncharacterized protein. (242 aa)
U7PR15_SPOS1PseudoU_synth_2 domain-containing protein. (589 aa)
U7PQY7_SPOS1tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA. (721 aa)
U7PQI1_SPOS1Uncharacterized protein. (370 aa)
U7PQ71_SPOS1Lysine-tRNA ligase. (660 aa)
U7PQ64_SPOS1Uncharacterized protein. (653 aa)
U7PPQ5_SPOS1Uncharacterized protein. (380 aa)
U7PPJ2_SPOS1Dextranase. (620 aa)
U7PP09_SPOS1Uncharacterized protein. (315 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (159 aa)
U7PNY7_SPOS1Formyl_trans_N domain-containing protein. (495 aa)
U7PNW1_SPOS1Uncharacterized protein. (396 aa)
U7PNV2_SPOS1Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (674 aa)
U7PNR6_SPOS1tRNA pseudouridine(38-40) synthase. (641 aa)
U7PND8_SPOS1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1340 aa)
U7PNB7_SPOS1SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (936 aa)
U7PN02_SPOS1tRNA pseudouridine(38-40) synthase. (568 aa)
U7PMY8_SPOS1Uncharacterized protein. (337 aa)
U7PMP6_SPOS1Alkylated DNA repair protein AlkB. (385 aa)
U7PME3_SPOS1Uncharacterized protein. (225 aa)
U7PM08_SPOS1Uncharacterized protein. (402 aa)
U7PLQ3_SPOS1Queuosine salvage protein; Involved in salvaging queuosine. (366 aa)
U7PLF9_SPOS1Uncharacterized protein. (270 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (489 aa)
U7PJT2_SPOS1Diphthamide biosynthesis protein 3. (86 aa)
U7PJS9_SPOS1tRNA-intron endonuclease. (616 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (110 aa)
U7PJC2_SPOS1Uncharacterized protein; Belongs to the CGI121/TPRKB family. (194 aa)
U7PJA1_SPOS1Uncharacterized protein. (959 aa)
U7PHZ6_SPOS1tRNA modification GTPase TrmE. (552 aa)
U7PHE5_SPOS1SAM_MT_TRM5_TYW2 domain-containing protein. (506 aa)
U7Q8T1_SPOS1ATP_bind_3 domain-containing protein. (787 aa)
U7Q838_SPOS1Uncharacterized protein. (416 aa)
U7Q7U7_SPOS1Uncharacterized protein. (315 aa)
U7Q7R0_SPOS1THUMP domain-containing protein. (218 aa)
U7Q7J7_SPOS1tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (536 aa)
U7Q7H2_SPOS1Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (559 aa)
U7Q6H7_SPOS1DUF3453 domain-containing protein. (819 aa)
U7Q6E1_SPOS1N2,N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (722 aa)
U7Q6B1_SPOS1Cysteine desulfurase, mitochondrial. (529 aa)
U7Q6A3_SPOS1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (467 aa)
U7Q5T0_SPOS1Sua5/YciO/YrdC/YwlC family protein. (463 aa)
U7Q5H8_SPOS1Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (386 aa)
U7Q5G3_SPOS1Uncharacterized protein. (691 aa)
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (559 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (401 aa)
ALA1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (960 aa)
U7Q555_SPOS1Uncharacterized protein. (145 aa)
U7Q4Y2_SPOS1Uncharacterized protein. (342 aa)
U7Q4K7_SPOS1Uncharacterized protein. (497 aa)
U7Q4I1_SPOS1tRNA pseudouridine(55) synthase. (526 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (80 aa)
U7Q4D7_SPOS1RRM domain-containing protein. (914 aa)
U7Q493_SPOS1SAM-dependent MTase TRM10-type domain-containing protein. (459 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1164 aa)
U7Q3R8_SPOS1tRNA_SAD domain-containing protein. (315 aa)
U7Q3I6_SPOS1U6 snRNA-associated Sm-like protein LSm6. (84 aa)
U7Q367_SPOS1Uncharacterized protein. (408 aa)
U7Q340_SPOS1Uncharacterized protein. (269 aa)
U7Q2X1_SPOS1Uncharacterized protein. (284 aa)
U7Q2Q3_SPOS1tRNA ligase. (844 aa)
U7Q2E5_SPOS1Uncharacterized protein. (529 aa)
U7Q274_SPOS1tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (297 aa)
U7Q1V8_SPOS1Uncharacterized protein. (355 aa)
U7Q1L3_SPOS1Ribonuclease P protein subunit. (304 aa)
U7Q1A8_SPOS1Uncharacterized protein. (303 aa)
U7Q166_SPOS1BUD32 protein kinase. (307 aa)
AIM41Altered inheritance of mitochondria protein 41. (201 aa)
U7Q127_SPOS1Flavodoxin-like domain-containing protein. (888 aa)
U7Q109_SPOS1tRNA_int_endo domain-containing protein. (446 aa)
U7Q0X4_SPOS1Uncharacterized protein. (494 aa)
U7Q0V7_SPOS1Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (1071 aa)
U7Q0N1_SPOS1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (111 aa)
U7Q0L7_SPOS1UPF0020 domain-containing protein. (518 aa)
U7Q0G9_SPOS1Sen15 domain-containing protein. (192 aa)
U7Q0B3_SPOS1Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (579 aa)
U7PZT4_SPOS1ThiF domain-containing protein. (600 aa)
U7PZS3_SPOS1Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (375 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (316 aa)
U7PZD3_SPOS1YrdC-like domain-containing protein. (242 aa)
U7PYR1_SPOS1Uncharacterized protein. (609 aa)
U7PYN2_SPOS1Methyltransf_25 domain-containing protein. (367 aa)
U7PYD4_SPOS1TRUD domain-containing protein. (882 aa)
U7PYD3_SPOS1tRNA_int_end_N2 domain-containing protein. (675 aa)
U7PY83_SPOS1WD_REPEATS_REGION domain-containing protein. (1377 aa)
U7PXW2_SPOS1A to I editase domain-containing protein. (413 aa)
U7PXS7_SPOS1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (310 aa)
U7PXD5_SPOS1Uncharacterized protein. (342 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (445 aa)
Your Current Organism:
Sporothrix schenckii
NCBI taxonomy Id: 1391915
Other names: S. schenckii ATCC 58251, Sporothrix schenckii ATCC 58251
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