(16 nodes) Ribosomal protein S5 domain 2-type fold, subgroup network (Sphaerochaeta globosa)

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Your Input:
	ADY11893.1	KEGG: tde:TDE2245 DNA topoisomerase IV subunit B; PFAM: DNA topoisomerase, type IIA, subunit B, domain 2; ATPase-like, ATP-binding domain; SMART: DNA topoisomerase, type IIA, subunit B/N-terminal; ATPase-like, ATP-binding domain. (600 aa)
	rnpA	Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (116 aa)
	ADY12220.1	Galactokinase; KEGG: bpb:bpr_I2414 GHMP kinase family protein; PFAM: GHMP kinase; GHMP kinase, C-terminal; Belongs to the GHMP kinase family. (394 aa)
	ADY13063.1	TIGRFAM: Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; KEGG: ssm:Spirs_2536 small GTP-binding protein; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal. (694 aa)
	fusA	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (676 aa)
	mutL	DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (588 aa)
	lon	Anti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (823 aa)
	ADY13530.1	KEGG: galK; galactokinase; PFAM: Galactokinase galactose-binding domain; GHMP kinase. (424 aa)
	ispE	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (294 aa)
	rpsI	PFAM: Ribosomal protein S9; KEGG: ssm:Spirs_3752 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (137 aa)
	fusA-2	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (702 aa)
	ADY14602.1	Galactokinase; KEGG: ssm:Spirs_3175 galactokinase; PFAM: GHMP kinase, C-terminal. (389 aa)
	rpsE	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (170 aa)
	ADY14736.1	Hypothetical protein; KEGG: ssm:Spirs_0321 peptidase S16 lon domain protein. (677 aa)
	radA	DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (450 aa)
	gyrB	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (677 aa)

Your Current Organism:

Sphaerochaeta globosa

NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADY12220.1	ADY13530.1	SpiBuddy_0384	SpiBuddy_1705	Galactokinase; KEGG: bpb:bpr_I2414 GHMP kinase family protein; PFAM: GHMP kinase; GHMP kinase, C-terminal; Belongs to the GHMP kinase family.	KEGG: galK; galactokinase; PFAM: Galactokinase galactose-binding domain; GHMP kinase.	0.929
ADY12220.1	ADY14602.1	SpiBuddy_0384	SpiBuddy_2794	Galactokinase; KEGG: bpb:bpr_I2414 GHMP kinase family protein; PFAM: GHMP kinase; GHMP kinase, C-terminal; Belongs to the GHMP kinase family.	Galactokinase; KEGG: ssm:Spirs_3175 galactokinase; PFAM: GHMP kinase, C-terminal.	0.976
ADY13063.1	fusA	SpiBuddy_1238	SpiBuddy_1240	TIGRFAM: Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; KEGG: ssm:Spirs_2536 small GTP-binding protein; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal.	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	0.495
ADY13063.1	rpsE	SpiBuddy_1238	SpiBuddy_2833	TIGRFAM: Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; KEGG: ssm:Spirs_2536 small GTP-binding protein; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal.	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	0.980
ADY13063.1	rpsI	SpiBuddy_1238	SpiBuddy_2195	TIGRFAM: Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; KEGG: ssm:Spirs_2536 small GTP-binding protein; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal.	PFAM: Ribosomal protein S9; KEGG: ssm:Spirs_3752 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.938
ADY13530.1	ADY12220.1	SpiBuddy_1705	SpiBuddy_0384	KEGG: galK; galactokinase; PFAM: Galactokinase galactose-binding domain; GHMP kinase.	Galactokinase; KEGG: bpb:bpr_I2414 GHMP kinase family protein; PFAM: GHMP kinase; GHMP kinase, C-terminal; Belongs to the GHMP kinase family.	0.929
ADY13530.1	ADY14602.1	SpiBuddy_1705	SpiBuddy_2794	KEGG: galK; galactokinase; PFAM: Galactokinase galactose-binding domain; GHMP kinase.	Galactokinase; KEGG: ssm:Spirs_3175 galactokinase; PFAM: GHMP kinase, C-terminal.	0.969
ADY14602.1	ADY12220.1	SpiBuddy_2794	SpiBuddy_0384	Galactokinase; KEGG: ssm:Spirs_3175 galactokinase; PFAM: GHMP kinase, C-terminal.	Galactokinase; KEGG: bpb:bpr_I2414 GHMP kinase family protein; PFAM: GHMP kinase; GHMP kinase, C-terminal; Belongs to the GHMP kinase family.	0.976
ADY14602.1	ADY13530.1	SpiBuddy_2794	SpiBuddy_1705	Galactokinase; KEGG: ssm:Spirs_3175 galactokinase; PFAM: GHMP kinase, C-terminal.	KEGG: galK; galactokinase; PFAM: Galactokinase galactose-binding domain; GHMP kinase.	0.969
fusA	ADY13063.1	SpiBuddy_1240	SpiBuddy_1238	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	TIGRFAM: Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; KEGG: ssm:Spirs_2536 small GTP-binding protein; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal.	0.495
fusA	rpsE	SpiBuddy_1240	SpiBuddy_2833	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	0.979
fusA	rpsI	SpiBuddy_1240	SpiBuddy_2195	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	PFAM: Ribosomal protein S9; KEGG: ssm:Spirs_3752 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.948
fusA-2	rpsE	SpiBuddy_2273	SpiBuddy_2833	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	0.960
fusA-2	rpsI	SpiBuddy_2273	SpiBuddy_2195	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	PFAM: Ribosomal protein S9; KEGG: ssm:Spirs_3752 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.929
rnpA	rpsE	SpiBuddy_0006	SpiBuddy_2833	Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	0.523
rnpA	rpsI	SpiBuddy_0006	SpiBuddy_2195	Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.	PFAM: Ribosomal protein S9; KEGG: ssm:Spirs_3752 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.691
rpsE	ADY13063.1	SpiBuddy_2833	SpiBuddy_1238	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	TIGRFAM: Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; KEGG: ssm:Spirs_2536 small GTP-binding protein; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal.	0.980
rpsE	fusA	SpiBuddy_2833	SpiBuddy_1240	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	0.979
rpsE	fusA-2	SpiBuddy_2833	SpiBuddy_2273	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	0.960
rpsE	rnpA	SpiBuddy_2833	SpiBuddy_0006	Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.	Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.	0.523