(31 nodes) AAA ATPase, AAA+ lid domain network (Paramormyrops kingsleyae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	LOC111857467	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family. (378 aa)
	atad1	ATPase family AAA domain containing 1b; Belongs to the AAA ATPase family. (373 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (591 aa)
	pex1	Peroxisomal biogenesis factor 1. (1290 aa)
	LOC111845149	N-ethylmaleimide-sensitive factor b. (748 aa)
	vps4b	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (438 aa)
	atad2b	ATPase family AAA domain containing 2B. (1423 aa)
	afg3l2	AFG3-like AAA ATPase 2. (815 aa)
	ENSPKIP00000019672	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (369 aa)
	psmc2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	spg7	SPG7 matrix AAA peptidase subunit, paraplegin. (852 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
	yme1l1	YME1-like 1a. (713 aa)
	Nvl	Nuclear VCP like. (832 aa)
	psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (481 aa)
	psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	LOC111859762	Uncharacterized protein. (750 aa)
	LOC111856597	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	LOC111840957	Zgc:136908; Belongs to the AAA ATPase family. (856 aa)
	SPATA5	Spermatogenesis associated 5. (876 aa)
	katnal1	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. (486 aa)
	LOC111859238	YME1-like 1b. (725 aa)
	Psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (413 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (839 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (752 aa)
	LOC111832706	AAA domain-containing protein. (764 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (505 aa)
	LOC111841780	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	katnal2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (529 aa)
	SPAST-2	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (563 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPKIP00000019672	SPAST	ENSPKIP00000019672	ENSPKIP00000003118	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.455
ENSPKIP00000019672	SPAST-2	ENSPKIP00000019672	ENSPKIP00000008911	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.462
ENSPKIP00000019672	katnal2	ENSPKIP00000019672	ENSPKIP00000006763	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.435
ENSPKIP00000019672	vps4b	ENSPKIP00000019672	ENSPKIP00000016847	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family.	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	0.494
KATNA1	psmc3	ENSPKIP00000001556	ENSPKIP00000033862	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.751
KATNA1	psmc4	ENSPKIP00000001556	ENSPKIP00000034637	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.743
KATNA1	psmc6	ENSPKIP00000001556	ENSPKIP00000005394	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.744
LOC111832706	LOC111859238	ENSPKIP00000001579	ENSPKIP00000039031	AAA domain-containing protein.	YME1-like 1b.	0.455
LOC111832706	spg7	ENSPKIP00000001579	ENSPKIP00000026008	AAA domain-containing protein.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.829
LOC111832706	yme1l1	ENSPKIP00000001579	ENSPKIP00000028192	AAA domain-containing protein.	YME1-like 1a.	0.454
LOC111840957	LOC111841780	ENSPKIP00000036921	ENSPKIP00000006655	Zgc:136908; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.670
LOC111840957	LOC111856597	ENSPKIP00000036921	ENSPKIP00000035487	Zgc:136908; Belongs to the AAA ATPase family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.900
LOC111840957	PSMC1	ENSPKIP00000036921	ENSPKIP00000027097	Zgc:136908; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.670
LOC111840957	Psmc5	ENSPKIP00000036921	ENSPKIP00000039146	Zgc:136908; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.707
LOC111840957	VCP	ENSPKIP00000036921	ENSPKIP00000040089	Zgc:136908; Belongs to the AAA ATPase family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.900
LOC111840957	psmc2	ENSPKIP00000036921	ENSPKIP00000022968	Zgc:136908; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.662
LOC111840957	psmc3	ENSPKIP00000036921	ENSPKIP00000033862	Zgc:136908; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.711
LOC111840957	psmc4	ENSPKIP00000036921	ENSPKIP00000034637	Zgc:136908; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.674
LOC111840957	psmc6	ENSPKIP00000036921	ENSPKIP00000005394	Zgc:136908; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.608
LOC111841780	LOC111840957	ENSPKIP00000006655	ENSPKIP00000036921	AAA domain-containing protein; Belongs to the AAA ATPase family.	Zgc:136908; Belongs to the AAA ATPase family.	0.670