(58 nodes) Valine, leucine and isoleucine degradation network (Panaeolus cyanescens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CVT24_000195	Dihydrolipoyl dehydrogenase. (502 aa)
	CVT24_011006	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (503 aa)
	CVT24_007903	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (495 aa)
	CVT24_006073	Uncharacterized protein. (789 aa)
	CVT24_007093	CoA carboxyltransferase C-terminal domain-containing protein. (604 aa)
	CVT24_010629	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa)
	CVT24_010609	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (494 aa)
	CVT24_010620	AB hydrolase-1 domain-containing protein. (496 aa)
	CVT24_007413	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (502 aa)
	CVT24_007417	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (500 aa)
	CVT24_007414	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
	CVT24_002319	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (441 aa)
	CVT24_011695	Uncharacterized protein. (236 aa)
	CVT24_011633	APH domain-containing protein. (476 aa)
	CVT24_001299	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
	CVT24_004127	YCII domain-containing protein; Belongs to the enoyl-CoA hydratase/isomerase family. (442 aa)
	CVT24_007789	Thiolase_C domain-containing protein. (132 aa)
	CVT24_006083	Aldedh domain-containing protein. (544 aa)
	CVT24_009090	Uncharacterized protein. (417 aa)
	CVT24_003224	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (531 aa)
	CVT24_011475	Uncharacterized protein. (1475 aa)
	CVT24_011513	Transket_pyr domain-containing protein. (421 aa)
	CVT24_005043	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (420 aa)
	CVT24_013274	Amino_oxidase domain-containing protein. (748 aa)
	CVT24_013279	Uncharacterized protein. (92 aa)
	CVT24_001074	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (523 aa)
	CVT24_006486	Thiolase_C domain-containing protein. (132 aa)
	CVT24_007942	Uncharacterized protein. (443 aa)
	CVT24_010143	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (504 aa)
	CVT24_008782	Amino_oxidase domain-containing protein. (363 aa)
	CVT24_011914	Uncharacterized protein. (696 aa)
	CVT24_002796	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	CVT24_000144	Pyruvate carboxyltransferase domain-containing protein. (360 aa)
	CVT24_013153	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (526 aa)
	CVT24_000503	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (406 aa)
	CVT24_005965	APH domain-containing protein. (391 aa)
	CVT24_008331	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (503 aa)
	CVT24_008325	Thiolase_N domain-containing protein. (211 aa)
	CVT24_005740	25S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family. (575 aa)
	CVT24_008868	Uncharacterized protein. (359 aa)
	CVT24_006081	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (376 aa)
	CVT24_010061	Amino_oxidase domain-containing protein. (329 aa)
	CVT24_009853	SET domain-containing protein. (433 aa)
	CVT24_006863	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	CVT24_003863	Uncharacterized protein. (625 aa)
	CVT24_011575	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	CVT24_006312	Amino_oxidase domain-containing protein. (756 aa)
	CVT24_006311	Amino_oxidase domain-containing protein. (611 aa)
	CVT24_000382	Uncharacterized protein. (739 aa)
	CVT24_005809	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (474 aa)
	CVT24_004262	FSH1 domain-containing protein. (1108 aa)
	CVT24_004272	Uncharacterized protein. (839 aa)
	CVT24_009661	Uncharacterized protein. (333 aa)
	CVT24_005313	Uncharacterized protein. (1035 aa)
	CVT24_003388	Uncharacterized protein. (421 aa)
	CVT24_003346	Uncharacterized protein. (652 aa)
	CVT24_003369	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (499 aa)
	CVT24_003999	Uncharacterized protein. (704 aa)

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT24_000144	CVT24_000503	A0A409WBT8	A0A409VAG6	Pyruvate carboxyltransferase domain-containing protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.850
CVT24_000144	CVT24_001074	A0A409WBT8	A0A409VX31	Pyruvate carboxyltransferase domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.490
CVT24_000144	CVT24_001299	A0A409WBT8	A0A409YG15	Pyruvate carboxyltransferase domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.490
CVT24_000144	CVT24_002319	A0A409WBT8	A0A409YII8	Pyruvate carboxyltransferase domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.774
CVT24_000144	CVT24_002796	A0A409WBT8	A0A409WCH5	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.932
CVT24_000144	CVT24_003224	A0A409WBT8	A0A409VFV2	Pyruvate carboxyltransferase domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.658
CVT24_000144	CVT24_003346	A0A409WBT8	A0A409Y760	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein.	0.900
CVT24_000144	CVT24_003369	A0A409WBT8	A0A409Y6X3	Pyruvate carboxyltransferase domain-containing protein.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.678
CVT24_000144	CVT24_003388	A0A409WBT8	A0A409Y762	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein.	0.475
CVT24_000144	CVT24_003999	A0A409WBT8	A0A409Y6D6	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein.	0.941
CVT24_000144	CVT24_004127	A0A409WBT8	A0A409Y678	Pyruvate carboxyltransferase domain-containing protein.	YCII domain-containing protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.761
CVT24_000144	CVT24_005043	A0A409WBT8	A0A409VPM5	Pyruvate carboxyltransferase domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.490
CVT24_000144	CVT24_005313	A0A409WBT8	A0A409Y9K0	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein.	0.825
CVT24_000144	CVT24_005809	A0A409WBT8	A0A409V902	Pyruvate carboxyltransferase domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.947
CVT24_000144	CVT24_006073	A0A409WBT8	A0A409VE58	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein.	0.634
CVT24_000144	CVT24_006081	A0A409WBT8	A0A409V8R5	Pyruvate carboxyltransferase domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.932
CVT24_000144	CVT24_006083	A0A409WBT8	A0A409VE60	Pyruvate carboxyltransferase domain-containing protein.	Aldedh domain-containing protein.	0.770
CVT24_000144	CVT24_006486	A0A409WBT8	A0A409WSX2	Pyruvate carboxyltransferase domain-containing protein.	Thiolase_C domain-containing protein.	0.721
CVT24_000144	CVT24_007093	A0A409WBT8	A0A409YNV8	Pyruvate carboxyltransferase domain-containing protein.	CoA carboxyltransferase C-terminal domain-containing protein.	0.825
CVT24_000144	CVT24_007413	A0A409WBT8	A0A409YKZ4	Pyruvate carboxyltransferase domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.490