(76 nodes) Pyruvate metabolism network (Elysia chlorotica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EGW08_005536	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (520 aa)
	EGW08_010109	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
	EGW08_020142	Malate dehydrogenase. (259 aa)
	EGW08_010208	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	EGW08_013297	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (562 aa)
	EGW08_016961	Bms1-type G domain-containing protein. (821 aa)
	EGW08_017232	Uncharacterized protein. (299 aa)
	EGW08_014696	Uncharacterized protein. (299 aa)
	EGW08_015099	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1196 aa)
	EGW08_021780	PK_C domain-containing protein. (154 aa)
	EGW08_023199	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (307 aa)
	EGW08_023025	Uncharacterized protein. (432 aa)
	EGW08_001310	Lactamase_B domain-containing protein. (299 aa)
	EGW08_000373	Lactamase_B domain-containing protein. (323 aa)
	EGW08_000273	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (71 aa)
	EGW08_000245	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
	EGW08_002262	Epimerase domain-containing protein. (357 aa)
	EGW08_001455	Malic enzyme. (555 aa)
	EGW08_002858	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (415 aa)
	EGW08_002860	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (242 aa)
	EGW08_004206	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (522 aa)
	EGW08_005261	Malate dehydrogenase. (331 aa)
	EGW08_005299	FAD-binding PCMH-type domain-containing protein. (173 aa)
	EGW08_009740	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
	EGW08_010036	Uncharacterized protein. (577 aa)
	EGW08_012330	DJ-1_PfpI domain-containing protein. (240 aa)
	EGW08_013719	Pyruvate kinase; Belongs to the pyruvate kinase family. (226 aa)
	EGW08_014206	Uncharacterized protein. (495 aa)
	EGW08_015018	Glutaredoxin domain-containing protein. (455 aa)
	EGW08_015307	Uncharacterized protein. (822 aa)
	EGW08_016625	Ldh_1_N domain-containing protein. (212 aa)
	EGW08_017011	Acetyl-coenzyme A synthetase. (689 aa)
	EGW08_017143	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (515 aa)
	EGW08_017229	Urb2 domain-containing protein. (118 aa)
	EGW08_018639	BBS1 domain-containing protein. (578 aa)
	EGW08_018852	Peripheral subunit-binding (PSBD) domain-containing protein. (438 aa)
	EGW08_018972	Uncharacterized protein. (484 aa)
	EGW08_019919	Pyruvate kinase; Belongs to the pyruvate kinase family. (282 aa)
	EGW08_020846	Lactamase_B domain-containing protein. (376 aa)
	EGW08_021115	Pyruvate kinase; Belongs to the pyruvate kinase family. (389 aa)
	EGW08_021179	Malic domain-containing protein. (134 aa)
	EGW08_021792	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (233 aa)
	EGW08_021916	Uncharacterized protein. (143 aa)
	EGW08_022291	Dihydrolipoyl dehydrogenase. (440 aa)
	EGW08_022167	Pyr_redox_2 domain-containing protein. (135 aa)
	EGW08_022605	Epimerase domain-containing protein. (201 aa)
	EGW08_022571	Lactamase_B domain-containing protein. (208 aa)
	EGW08_023156	Uncharacterized protein. (563 aa)
	EGW08_007614	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (139 aa)
	EGW08_020322	Uncharacterized protein. (643 aa)
	EGW08_021159	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	EGW08_023475	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (212 aa)
	EGW08_023683	FAD-binding PCMH-type domain-containing protein. (166 aa)
	EGW08_000418	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (411 aa)
	EGW08_014650	3Beta_HSD domain-containing protein. (285 aa)
	EGW08_004765	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (719 aa)
	EGW08_005297	Uncharacterized protein. (631 aa)
	EGW08_001481	Uncharacterized protein. (617 aa)
	EGW08_007042	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	EGW08_008067	PPDK_N domain-containing protein. (1241 aa)
	EGW08_014400	RING-type domain-containing protein. (541 aa)
	EGW08_015881	Uncharacterized protein. (530 aa)
	EGW08_016809	Uncharacterized protein. (662 aa)
	EGW08_013632	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (426 aa)
	EGW08_022880	Uncharacterized protein. (472 aa)
	EGW08_022943	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (354 aa)
	EGW08_019375	Malic enzyme. (448 aa)
	EGW08_005215	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (539 aa)
	EGW08_008947	Uncharacterized protein. (356 aa)
	EGW08_010108	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (362 aa)
	EGW08_000001	FAD-binding PCMH-type domain-containing protein. (318 aa)
	EGW08_003237	Lactamase_B domain-containing protein. (243 aa)
	EGW08_004475	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
	EGW08_004750	Uncharacterized protein. (320 aa)
	EGW08_004876	Dihydrolipoyl dehydrogenase. (505 aa)
	EGW08_005807	NmrA domain-containing protein. (453 aa)

Your Current Organism:

Elysia chlorotica

NCBI taxonomy Id: 188477
Other names: E. chlorotica, eastern emerald elysia, emerald elysia

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGW08_000001	EGW08_000245	A0A3S1A2F3	A0A433UE40	FAD-binding PCMH-type domain-containing protein.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.911
EGW08_000001	EGW08_000373	A0A3S1A2F3	A0A433UDH2	FAD-binding PCMH-type domain-containing protein.	Lactamase_B domain-containing protein.	0.413
EGW08_000001	EGW08_001310	A0A3S1A2F3	A0A433UAU4	FAD-binding PCMH-type domain-containing protein.	Lactamase_B domain-containing protein.	0.902
EGW08_000001	EGW08_001455	A0A3S1A2F3	A0A433UA87	FAD-binding PCMH-type domain-containing protein.	Malic enzyme.	0.910
EGW08_000001	EGW08_003237	A0A3S1A2F3	A0A3S0ZXA5	FAD-binding PCMH-type domain-containing protein.	Lactamase_B domain-containing protein.	0.413
EGW08_000001	EGW08_004750	A0A3S1A2F3	A0A3S0ZV51	FAD-binding PCMH-type domain-containing protein.	Uncharacterized protein.	0.549
EGW08_000001	EGW08_005299	A0A3S1A2F3	A0A433TZG3	FAD-binding PCMH-type domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.941
EGW08_000001	EGW08_010108	A0A3S1A2F3	A0A3S1A3W3	FAD-binding PCMH-type domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.909
EGW08_000001	EGW08_013719	A0A3S1A2F3	A0A433TA93	FAD-binding PCMH-type domain-containing protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.803
EGW08_000001	EGW08_014696	A0A3S1A2F3	A0A3S0ZH61	FAD-binding PCMH-type domain-containing protein.	Uncharacterized protein.	0.474
EGW08_000001	EGW08_015099	A0A3S1A2F3	A0A3S0ZEL0	FAD-binding PCMH-type domain-containing protein.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.901
EGW08_000001	EGW08_019375	A0A3S1A2F3	A0A3S1AUX1	FAD-binding PCMH-type domain-containing protein.	Malic enzyme.	0.826
EGW08_000001	EGW08_019919	A0A3S1A2F3	A0A433SST9	FAD-binding PCMH-type domain-containing protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.803
EGW08_000001	EGW08_020846	A0A3S1A2F3	A0A433SQ70	FAD-binding PCMH-type domain-containing protein.	Lactamase_B domain-containing protein.	0.413
EGW08_000001	EGW08_021115	A0A3S1A2F3	A0A433SPH1	FAD-binding PCMH-type domain-containing protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.823
EGW08_000001	EGW08_021179	A0A3S1A2F3	A0A433SPB2	FAD-binding PCMH-type domain-containing protein.	Malic domain-containing protein.	0.898
EGW08_000001	EGW08_021780	A0A3S1A2F3	A0A3S0ZAH6	FAD-binding PCMH-type domain-containing protein.	PK_C domain-containing protein.	0.823
EGW08_000001	EGW08_022571	A0A3S1A2F3	A0A433SKK1	FAD-binding PCMH-type domain-containing protein.	Lactamase_B domain-containing protein.	0.413
EGW08_000001	EGW08_023199	A0A3S1A2F3	A0A3S0Z491	FAD-binding PCMH-type domain-containing protein.	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	0.650
EGW08_000001	EGW08_023475	A0A3S1A2F3	A0A3S1GYL3	FAD-binding PCMH-type domain-containing protein.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.474