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| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa) |
| | dnaN | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (366 aa) |
| | rep | ATP-dependent DNA helicase rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (673 aa) |
| | xerC | Integrase/recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges [...] (298 aa) |
| | uvrD | DNA helicase II; Escherichia coli K-12 ortholog: b3813; Escherichia coli O157:H7 ortholog: z5330. (738 aa) |
| | recQ | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. (611 aa) |
| | yigW | Conserved hypothetical protein; 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily. (264 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (756 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. (483 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa) |
| | c5175 | Hypothetical protein; Residues 1 to 43 of 43 are 88.37 pct identical to residues 358 to 400 of 400 from GenPept.129 : >gb|AAK69271.1|AF336309_66 (AF336309) unknown [Yersinia enterocolitica]. (43 aa) |
| | hepA | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (968 aa) |
| | polB | DNA polymerase II; Escherichia coli K-12 ortholog: b0060; Escherichia coli O157:H7 ortholog: z0068. (783 aa) |
| | c0072 | Transposase; Residues 18 to 169 of 169 are 94.07 pct identical to residues 1 to 152 of 152 from SwissProt.40 : >sp|Q57334|T200_SALTY Transposase for insertion sequence element IS200. (169 aa) |
| | c0086 | Transposase; Residues 18 to 169 of 169 are 95.39 pct identical to residues 1 to 152 of 152 from SwissProt.40 : >sp|Q57334|T200_SALTY Transposase for insertion sequence element IS200. (169 aa) |
| | c0138 | Unknown protein of IS629 encoded within prophage; Escherichia coli O157:H7 ortholog: z2982. (108 aa) |
| | dnaE | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). (1160 aa) |
| | dnaQ | DNA polymerase III, epsilon chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (246 aa) |
| | c0256 | Hypothetical protein; Residues 7 to 69 of 73 are 66.66 pct identical to residues 5 to 67 of 141 from GenPept.129 : >gb|AAG55763.1|AE005312_9 (AE005312) unknown in putative ISEc8 [Escherichia coli O157:H7 EDL933]. (73 aa) |
| | c0261 | Hypothetical protein; Residues 8 to 372 of 377 are 47.26 pct identical to residues 39 to 390 of 390 from SwissProt.40 : >sp|P55626|Y4QE_RHISN PUTATIVE TRANSPOSASE Y4QE. (377 aa) |
| | c0349 | Putative Transposase within prophage; Required for the transposition of the insertion element. (374 aa) |
| | dinP | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). (351 aa) |
| | xseB | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa) |
| | dnaX | DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (643 aa) |
| | holA | DNA polymerase III, delta subunit; Escherichia coli K-12 ortholog: b0640; Escherichia coli O157:H7 ortholog: z0787. (343 aa) |
| | phrB | Deoxyribodipyrimidine photolyase; Escherichia coli K-12 ortholog: b0708; Escherichia coli O157:H7 ortholog: z0859; Belongs to the DNA photolyase family. (472 aa) |
| | nei | Endonuclease VIII; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (673 aa) |
| | dinG | Probable ATP-dependent helicase dinG; DNA-dependent ATPase and 5'-3' DNA helicase. (716 aa) |
| | c0941 | DNA adenine methylase; Escherichia coli K-12 ortholog: b3387; Escherichia coli O157:H7 ortholog: z4740. (285 aa) |
| | helD | Helicase IV; Escherichia coli K-12 ortholog: b0962; Escherichia coli O157:H7 ortholog: z1313. (715 aa) |
| | c1168 | Unknown in IS1N; Escherichia coli O157:H7 ortholog: z1562. (130 aa) |
| | c1225 | Transposase insE for insertion sequence IS3A/B/C/D/E/fA/fB; Escherichia coli K-12 ortholog: b2088. (74 aa) |
| | c1271 | Hypothetical protein; Residues 1 to 80 of 98 are 48.75 pct identical to residues 19 to 92 of 520 from GenPept.129 : >emb|CAA31541.1| (X13145) hsdM protein (AA 1-520) [Escherichia coli]. (98 aa) |
| | holB | DNA polymerase III, delta' subunit; Escherichia coli K-12 ortholog: b1099; Escherichia coli O157:H7 ortholog: z1738. (334 aa) |
| | ycfH | Putative deoxyribonuclease ycfH; Escherichia coli K-12 ortholog: b1100; Escherichia coli O157:H7 ortholog: z1739. (285 aa) |
| | c1400 | Prophage lambda integrase; Int(Lambda); Escherichia coli K-12 ortholog: b1140; Escherichia coli O157:H7 ortholog: z1764; Belongs to the 'phage' integrase family. (372 aa) |
| | recE | Exodeoxyribonuclease VIII; Escherichia coli K-12 ortholog: b1350. (813 aa) |
| | c1519 | Prophage lambda integrase; Int(Lambda); Escherichia coli K-12 ortholog: b1140; Escherichia coli O157:H7 ortholog: z1866; Belongs to the 'phage' integrase family. (380 aa) |
| | c1555 | Putative DNA N-6-adenine-methyltransferase of bacteriophage; Escherichia coli O157:H7 ortholog: z1454. (185 aa) |
| | rus | Crossover junction endodeoxyribonuclease rusA; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC (By similarity); Belongs to the RusA family. (120 aa) |
| | c1704 | Transposase insG for insertion sequence element IS4; Escherichia coli K-12 ortholog: b4278. (401 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (879 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | xthA | Exodeoxyribonuclease III; Escherichia coli K-12 ortholog: b1749; Escherichia coli O157:H7 ortholog: z2781. (272 aa) |
| | sms | DNA repair protein radA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (476 aa) |
| | holD | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (137 aa) |
| | c5424 | Putative restriction modification enzyme M subunit; Methylase; Escherichia coli O157:H7 ortholog: z5947. (507 aa) |
| | c5378 | Hypothetical protein; Residues 1 to 1090 of 1092 are 60.92 pct identical to residues 1 to 1088 of 1089 from GenPept.129 : >gb|AAK02780.1| (AE006106) unknown [Pasteurella multocida]. (1092 aa) |
| | c5373 | Hypothetical protein; Residues 2 to 668 of 670 are 43.91 pct identical to residues 3 to 634 of 636 from GenPept.129 : >gb|AAK02782.1| (AE006106) unknown [Pasteurella multocida]. (670 aa) |
| | c5372 | Hypothetical protein; Residues 1 to 1022 of 1023 are 51.23 pct identical to residues 1 to 1041 of 1043 from GenPept.129 : >gb|AAK02783.1| (AE006106) unknown [Pasteurella multocida]. (1023 aa) |
| | holC | DNA polymerase III, chi subunit; Escherichia coli K-12 ortholog: b4259; Escherichia coli O157:H7 ortholog: z5871. (147 aa) |
| | mutL | DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (616 aa) |
| | c5196 | Transposase insC for insertion element IS2A/D/F/H/I/K; Escherichia coli K-12 ortholog: b1997. (96 aa) |
| | c5176 | Putative Transposase within prophage; Required for the transposition of the insertion element. (260 aa) |
| | topB | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (667 aa) |
| | holE | DNA polymerase III, theta subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). (105 aa) |
| | ruvB | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa) |
| | ruvA | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity). (174 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity). (610 aa) |
| | dcm | DNA-cytosine methyltransferase; Escherichia coli K-12 ortholog: b1961; Escherichia coli O157:H7 ortholog: z3054. (472 aa) |
| | c2472 | Transposase; Residues 1 to 88 of 88 are 71.59 pct identical to residues 1 to 88 of 88 from SwissProt.40 : >sp|Q00931|LCRS_YERPE Low calcium response locus protein S. (88 aa) |
| | c2503 | Transposase; Residues 6 to 393 of 398 are 58.82 pct identical to residues 3 to 393 of 405 from SwissProt.40 : >sp|P19780|YIS1_STRCO Insertion element IS110 hypothetical 43.6 kDa protein. (398 aa) |
| | c2512 | Transposase; Residues 1 to 340 of 340 are 99.70 pct identical to residues 1 to 340 of 340 from GenPept.129 : >emb|CAC43410.1| (X16664) Y1093 protein [Escherichia coli]. (340 aa) |
| | sbcB | Escherichia coli K-12 ortholog: b2011; Escherichia coli O157:H7 ortholog: z3173. (491 aa) |
| | alkA | DNA-3-methyladenine glycosylase II; Escherichia coli K-12 ortholog: b2068; Escherichia coli O157:H7 ortholog: z3237. (282 aa) |
| | nfo | Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (285 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (875 aa) |
| | yfcB | Hypothetical adenine-specific methylase yfcB; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (421 aa) |
| | lig | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa) |
| | xseA | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (458 aa) |
| | ung | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (229 aa) |
| | pinR | Putative DNA-invertase from lambdoid prophage Rac; Escherichia coli K-12 ortholog: b1374; Escherichia coli O157:H7 ortholog: z5885; Belongs to the site-specific recombinase resolvase family. (196 aa) |
| | c3189 | Hypothetical protein; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC; Belongs to the rusA family. (129 aa) |
| | recA | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa) |
| | mutS | DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (853 aa) |
| | exo | Exodeoxyribonuclease IX; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. (281 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (608 aa) |
| | recB | Exodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...] (1183 aa) |
| | recC | Exodeoxyribonuclease V gamma chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (1122 aa) |
| | c3432 | Transposase; Residues 1 to 112 of 112 are 96.42 pct identical to residues 41 to 152 of 152 from SwissProt.40 : >sp|Q57334|T200_SALTY Transposase for insertion sequence element IS200. (112 aa) |
| | xerD | Integrase/recombinase xerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges [...] (298 aa) |
| | endA | Endonuclease I precursor; Escherichia coli K-12 ortholog: b2945; Escherichia coli O157:H7 ortholog: z4290. (236 aa) |
| | mutY | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (360 aa) |
| | c3560 | Unknown protein encoded by ISEc8 within prophage; Escherichia coli O157:H7 ortholog: z5096. (134 aa) |
| | c3576 | Unknown in IS; Escherichia coli O157:H7 ortholog: z1589. (100 aa) |
| | c3577 | Unknown protein encoded by ISEc8 within prophage; Escherichia coli O157:H7 ortholog: z5096. (133 aa) |
| | c3596 | Hypothetical protein in IS; Escherichia coli O157:H7 ortholog: z5879. (108 aa) |
| | c3612 | Transposase insC for insertion element IS2A/D/F/H/I/K; Escherichia coli K-12 ortholog: b4272. (124 aa) |
| | c3617 | Unknown in putative ISEc8; Escherichia coli O157:H7 ortholog: z1648. (145 aa) |
| | c3640 | Unknown in ISEc8; Escherichia coli O157:H7 ortholog: z1598. (120 aa) |
| | c3659 | Unknown protein encoded by ISEc8; Escherichia coli O157:H7 ortholog: z4315. (215 aa) |
| | c3703 | Transposase insG for insertion sequence element IS4; Escherichia coli K-12 ortholog: b4278. (449 aa) |
| | parC | Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (752 aa) |
| | parE | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa) |
| | c3803 | Putative Transposase; Escherichia coli O157:H7 ortholog: z5815. (150 aa) |
| | ygjF | G/U mismatch-specific DNA glycosylase; Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells; Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. (168 aa) |
| | yrdD | Hypothetical protein yrdD; Escherichia coli K-12 ortholog: b3283; Escherichia coli O157:H7 ortholog: z4654. (180 aa) |
| | dam | DNA adenine methylase; Escherichia coli K-12 ortholog: b3387; Escherichia coli O157:H7 ortholog: z4740. (278 aa) |
| | tag | DNA-3-methyladenine glycosylase I; Escherichia coli K-12 ortholog: b3549; Escherichia coli O157:H7 ortholog: z4974. (242 aa) |
| | mutM | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa) |
| | yicF | Hypothetical DNA ligase-like protein yicF; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. (562 aa) |
| | recG | ATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (704 aa) |
| | c4498 | IS1 protein InsB; Escherichia coli O157:H7 ortholog: z1632. (105 aa) |
| | insB | Insertion element IS1 1/5/6 protein insB; Escherichia coli K-12 ortholog: b3445; Escherichia coli O157:H7 ortholog: z1562. (119 aa) |
| | insI | Transposase insI for insertion sequence element IS30B/C/D; Escherichia coli K-12 ortholog: b4284; Escherichia coli O157:H7 ortholog: z2993. (383 aa) |
| | c4552 | Transposase insC for insertion element IS2A/D/F/H/I/K; Escherichia coli K-12 ortholog: b4272. (111 aa) |
