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c0503 c0503 manA manA pfkB pfkB yniC yniC ydjJ ydjJ manX manX manY manY manZ manZ yedP yedP manB manB c2558 c2558 cpsG cpsG cpsB cpsB wcaG wcaG gmd gmd fbaB fbaB fruA fruA fruK fruK yfaU yfaU yfaW yfaW yfbT yfbT srlA srlA srlE srlE srlB srlB srlD srlD fucA fucA fucI fucI fba fba c3514 c3514 cmtA cmtA cmtB cmtB xylA xylA mtlA mtlA mtlD mtlD c4482 c4482 c4483 c4483 c4484 c4484 c4485 c4485 c4486 c4486 c4487 c4487 rhaD rhaD rhaA rhaA rhaB rhaB pfkA pfkA tpiA tpiA glpX glpX c4981 c4981 c4982 c4982 c4983 c4983 c4984 c4984 c4985 c4985 c4986 c4986 yjcT yjcT yjcU yjcU rpiB rpiB fbp fbp
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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c0503Hypothetical protein yajF; Escherichia coli K-12 ortholog: b0394; Escherichia coli O157:H7 ortholog: z0493. (348 aa)
manAMannose-6-phosphate isomerase; Escherichia coli K-12 ortholog: b1613; Escherichia coli O157:H7 ortholog: z2616; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa)
pfkB6-phosphofructokinase isozyme 2; Escherichia coli K-12 ortholog: b1723; Escherichia coli O157:H7 ortholog: z2752; Belongs to the carbohydrate kinase PfkB family. (310 aa)
yniCHypothetical protein yniC; Escherichia coli K-12 ortholog: b1727; Escherichia coli O157:H7 ortholog: z2756. (222 aa)
ydjJHypothetical zinc-type alcohol dehydrogenase-like protein ydjJ; Escherichia coli K-12 ortholog: b1774; Escherichia coli O157:H7 ortholog: z2812. (347 aa)
manXPTS system, mannose-specific IIAB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA. (323 aa)
manYPTS system, mannose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA. (266 aa)
manZPTS system, mannose-specific IID component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA. (286 aa)
yedPHypothetical protein yedP; Escherichia coli K-12 ortholog: b1955; Escherichia coli O157:H7 ortholog: z3045. (271 aa)
manBPhosphomannomutase; Escherichia coli K-12 ortholog: b2048; Escherichia coli O157:H7 ortholog: z3194. (456 aa)
c2558Mannose-1-phosphate guanylyltransferase; GDP; Escherichia coli K-12 ortholog: b2049; Escherichia coli O157:H7 ortholog: z3213; Belongs to the mannose-6-phosphate isomerase type 2 family. (483 aa)
cpsGPhosphomannomutase; Escherichia coli K-12 ortholog: b2048; Escherichia coli O157:H7 ortholog: z3212. (472 aa)
cpsBMannose-1-phosphate guanylyltransferase; GDP; Escherichia coli K-12 ortholog: b2049; Escherichia coli O157:H7 ortholog: z3213; Belongs to the mannose-6-phosphate isomerase type 2 family. (478 aa)
wcaGGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (373 aa)
fbaBFructose-bisphosphate aldolase class I; Escherichia coli K-12 ortholog: b2097; Escherichia coli O157:H7 ortholog: z3260. (374 aa)
fruAPTS system, fructose-specific IIBC component; EIIBC-Fru; Escherichia coli K-12 ortholog: b2167; Escherichia coli O157:H7 ortholog: z3425. (563 aa)
fruK1-phosphofructokinase; Escherichia coli K-12 ortholog: b2168; Escherichia coli O157:H7 ortholog: z3426; Belongs to the carbohydrate kinase PfkB family. (312 aa)
yfaUHypothetical protein yfaU; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. (267 aa)
yfaWHypothetical protein yfaW; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). (405 aa)
yfbTProtein yfbT; Escherichia coli K-12 ortholog: b2293; Escherichia coli O157:H7 ortholog: z3554. (216 aa)
srlAPTS system, glucitol/sorbitol-specific IIC2 component; EIIC2-GUT; Escherichia coli K-12 ortholog: b2702; Escherichia coli O157:H7 ortholog: z4005. (187 aa)
srlEPTS system, glucitol/sorbitol-specific IIBC component; EIIBC-GUT; Escherichia coli K-12 ortholog: b2703; Escherichia coli O157:H7 ortholog: z4009. (319 aa)
srlBPTS system, glucitol/sorbitol-specific IIA component; EIIA-gut; Escherichia coli K-12 ortholog: b2704; Escherichia coli O157:H7 ortholog: z4011. (123 aa)
srlDSorbitol-6-phosphate 2-dehydrogenase; Escherichia coli K-12 ortholog: b2705; Escherichia coli O157:H7 ortholog: z4012; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
fucAL-fuculose phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa)
fucIL-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (591 aa)
fbaFructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (387 aa)
c3514Putative oxidoreductase; Escherichia coli K-12 ortholog: b2931; Escherichia coli O157:H7 ortholog: z4276. (425 aa)
cmtAPTS system, mannitol (Cryptic)-specific IIBC component; EIIBC-(C)MTL; Escherichia coli K-12 ortholog: b2933; Escherichia coli O157:H7 ortholog: z4277. (462 aa)
cmtBPTS system, mannitol (Cryptic)-specific IIA component; EIIA-(C)MTL; Escherichia coli K-12 ortholog: b2934; Escherichia coli O157:H7 ortholog: z4278. (147 aa)
xylAXylose isomerase; Escherichia coli K-12 ortholog: b3565; Escherichia coli O157:H7 ortholog: z4990; Belongs to the xylose isomerase family. (444 aa)
mtlAPTS system, mannitol-specific IIABC component; EIIABC-MTL; Escherichia coli K-12 ortholog: b3599; Escherichia coli O157:H7 ortholog: z5023. (637 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase; Escherichia coli K-12 ortholog: b3600; Escherichia coli O157:H7 ortholog: z5024. (442 aa)
c4482Hypothetical protein yajF; Escherichia coli K-12 ortholog: b0394; Escherichia coli O157:H7 ortholog: z0493. (321 aa)
c4483Putative aldolase; Escherichia coli O157:H7 ortholog: z5687. (286 aa)
c4484Putative aldolase; Residues 1 to 283 of 283 are 39.78 pct identical to residues 1 to 283 of 284 from GenPept.129 : >emb|CAD00212.1| (AL591982) similar to fructose-1,6-biphosphate aldolase type II [Listeria monocytogenes]. (283 aa)
c4485Putative PTS enzyme-ii fructose; Residues 11 to 358 of 363 are 53.10 pct identical to residues 5 to 355 of 363 from GenPept.129 : >emb|CAC97469.1| (AL596171) similar to PTS system, fructose-specific enzyme IIC component [Listeria innocua]. (363 aa)
c4486PTS system, fructose-like-2 IIB component 1; Phosphotransferase enzyme II, B component; Escherichia coli K-12 ortholog: b3950; Escherichia coli O157:H7 ortholog: z5506. (104 aa)
c4487Putative phosphotransferase system (PTS), fructose-specific; Residues 1 to 149 of 156 are 48.32 pct identical to residues 6 to 154 of 157 from GenPept.129 : >emb|CAC97471.1| (AL596171) similar to PTS system, fructose-specific enzyme IIA component [Listeria innocua]. (156 aa)
rhaDRhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (305 aa)
rhaAL-rhamnose isomerase; Escherichia coli K-12 ortholog: b3903; Escherichia coli O157:H7 ortholog: z5447. (421 aa)
rhaBRhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. (489 aa)
pfkA6-phosphofructokinase isozyme I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (352 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
glpXProtein glpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate; Belongs to the FBPase class 2 family. (336 aa)
c4981Putative oxidoreductase; Escherichia coli K-12 ortholog: b2931; Escherichia coli O157:H7 ortholog: z5613. (409 aa)
c4982PTS system, mannose-specific IID component; EIID-Man; Escherichia coli K-12 ortholog: b1819; Escherichia coli O157:H7 ortholog: z5614. (284 aa)
c4983PTS system, mannose-specific IIC component; EIIC-Man; Escherichia coli K-12 ortholog: b1818; Escherichia coli O157:H7 ortholog: z5615. (265 aa)
c4984Putative sorbose PTS component; Escherichia coli O157:H7 ortholog: z5616. (164 aa)
c4985Putative sorbose PTS component; Escherichia coli O157:H7 ortholog: z5617. (135 aa)
c4986D-glucitol-6-phosphate dehydrogenase; Escherichia coli O157:H7 ortholog: z5618; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (268 aa)
yjcTD-allose kinase; Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate. (309 aa)
yjcUD-allulose-6-phosphate 3-epimerase; Escherichia coli K-12 ortholog: b4085. (233 aa)
rpiBRibose 5-phosphate isomerase B; Escherichia coli K-12 ortholog: b4090. (149 aa)
fbpFructose-1,6-bisphosphatase; Escherichia coli K-12 ortholog: b4232; Escherichia coli O157:H7 ortholog: z5842. (353 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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