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ACEE_09000 ACEE_09000 dnaA dnaA recF recF pilF pilF rpsF rpsF priB priB rpsR rpsR rplI rplI priA_2 priA_2 spsE spsE ACEE_01470 ACEE_01470 rpsO rpsO rpmI rpmI rplT rplT ACEE_01770 ACEE_01770 rpmE rpmE kdkA kdkA raiA raiA ACEE_02195 ACEE_02195 ACEE_02580 ACEE_02580 mreB_1 mreB_1 rarA_3 rarA_3 ACEE_03000 ACEE_03000 topB2 topB2 rpsA_1 rpsA_1 ihfB ihfB dnaB2_2 dnaB2_2 ACEE_03710 ACEE_03710 sspB_1 sspB_1 ACEE_03775 ACEE_03775 ACEE_03930 ACEE_03930 infB_1 infB_1 ihfA ihfA rpsI rpsI rplM rplM guaB_4 guaB_4 pdxS pdxS rpsB_1 rpsB_1 tadD tadD recO recO rplY rplY ACEE_04720 ACEE_04720 ACEE_04770 ACEE_04770 nth_1 nth_1 ACEE_05775 ACEE_05775 recQ_2 recQ_2 fis fis ACEE_06380 ACEE_06380 rnfC_1 rnfC_1 hupA hupA ACEE_07075 ACEE_07075 recR recR recN_3 recN_3 rpmA rpmA rplU rplU rpmG rpmG rpmB rpmB radC_2 radC_2 slmA slmA dtd dtd rpmH rpmH ACEE_08415 ACEE_08415 ACEE_08490 ACEE_08490 rpmJ rpmJ rpmE2 rpmE2 rpsP rpsP rplQ rplQ rpsD_2 rpsD_2 rpsK rpsK rpmJ-2 rpmJ-2 rplO rplO rpmD rpmD rpsE_1 rpsE_1 rplR rplR rplF_1 rplF_1 rpsH_2 rpsH_2 rpsN rpsN rplE_1 rplE_1 rplX rplX rplN_1 rplN_1 rpsQ rpsQ rplP rplP rpsC_1 rpsC_1 rplV rplV rpsS_1 rpsS_1 rplB rplB rplW rplW rplD rplD rplC_2 rplC_2 rpsJ rpsJ sxy sxy rpsT rpsT rplL rplL rplJ rplJ rplA rplA rplK rplK ACEE_09545 ACEE_09545 rpsG_2 rpsG_2 rpsU rpsU dnaG dnaG rpmF rpmF yfgE_1 yfgE_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ACEE_0900050S ribosomal protein L29; One of the stabilizing components for the large ribosomal subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
dnaAChromosomal replication initiation protein; Binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
recFRecombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (360 aa)
pilFFimbrial protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (124 aa)
priBPrimosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS). (124 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rplI50S ribosomal protein L9; In Escherichia coli this protein is wrapped around the base of the L1 stalk; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
priA_2Primosomal protein N; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)
spsEN-acetyl neuramic acid synthetase NeuB; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
ACEE_01470Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
rpsO30S ribosomal protein S15; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS15 family. (89 aa)
rpmI50S ribosomal protein L35; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
ACEE_01770Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (70 aa)
kdkACatalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
raiARibosome-associated inhibitor A; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
ACEE_02195Methanol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
ACEE_02580Propanediol utilization protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
mreB_1Rod shape-determining protein MreB; Functions in MreBCD complex in some organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
rarA_3Recombination factor protein RarA; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
ACEE_03000Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
topB2DNA topoisomerase III; Decatenates replicating daughter chromosomes; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
rpsA_130S ribosomal protein S1; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
ihfBIntegration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (93 aa)
dnaB2_2DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
ACEE_03710UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (862 aa)
sspB_1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
ACEE_03775Primosomal replication protein N; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
ACEE_03930Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (60 aa)
infB_1Translation initiation factor IF-2; Derived by automated computational analysis using gene prediction method: Protein Homology. (839 aa)
ihfAIntegration host factor subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa)
rpsI30S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (131 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
guaB_4Inosine-5-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (488 aa)
pdxSPyridoxal biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa)
rpsB_130S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (238 aa)
tadDNrfG protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (240 aa)
rplY50S ribosomal protein L25; The Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
ACEE_04720DNA helicase; Unwinds double stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
ACEE_04770DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (680 aa)
nth_1Endonuclease III; DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
ACEE_05775Cell envelope biogenesis protein TolA; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
recQ_2ATP-dependent DNA helicase RecQ; Functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
fisFis family transcriptional regulator; Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa)
ACEE_06380Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
rnfC_1Electron transporter RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (808 aa)
hupADNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
ACEE_07075Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection; Belongs to the YbaB/EbfC family. (109 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
recN_3Recombination and repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
rpmA50S ribosomal protein L27; Involved in the peptidyltransferase reaction during translation; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmG50S ribosomal protein L33; In Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; Derived by automated computational analysis using gene prediction method: Protein Homology. (56 aa)
rpmB50S ribosomal protein L28; Required for 70S ribosome assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
radC_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
slmADivision inhibitor protein; FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (144 aa)
rpmH50S ribosomal protein L34; In Escherichia coli transcription of this gene is enhanced by polyamines; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
ACEE_08415Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
ACEE_08490Ter macrodomain organizer matS-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
rpmJ50S ribosomal protein L36; Smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; Derived by automated computational analysis using gene prediction method: Protein Homology. (41 aa)
rpmE250S ribosomal protein L31 type B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL31 family. (91 aa)
rpsP30S ribosomal protein S16; Binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
rplQ50S ribosomal protein L17; Is a component of the macrolide binding site in the peptidyl transferase center; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
rpsD_230S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpmJ-250S ribosomal protein L36; Smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; Derived by automated computational analysis using gene prediction method: Protein Homology. (37 aa)
rplO50S ribosomal protein L15; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
rpmD50S ribosomal protein L30; L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; Derived by automated computational analysis using gene prediction method: Protein Homology. (59 aa)
rpsE_130S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplF_150S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. (177 aa)
rpsH_230S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
rpsN30S ribosomal protein S14; Located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
rplE_150S ribosomal protein L5; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
rplX50S ribosomal protein L24; Assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
rplN_150S ribosomal protein L14; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rpsQ30S ribosomal protein S17; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpsC_130S ribosomal protein S3; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS3 family. (234 aa)
rplV50S ribosomal protein L22; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
rpsS_130S ribosomal protein S19; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS19 family. (91 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (101 aa)
rplDL4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
rplC_250S ribosomal protein L3; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
sxyDNA transformation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
rpsT30S ribosomal protein S20; Binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (163 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplK50S ribosomal protein L11; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
ACEE_09545Adhesin; Derived by automated computational analysis using gene prediction method: Protein Homology. (682 aa)
rpsG_230S ribosomal protein S7; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
rpsU30S ribosomal protein S21; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
dnaGDNA primase; Synthesizes RNA primers at the replication forks; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
rpmFSome L32 proteins have zinc finger motifs consisting of CXXC while others do not; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
yfgE_1DNA replication protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DnaA family. (236 aa)
Your Current Organism:
Actinobacillus equuli
NCBI taxonomy Id: 202947
Other names: A. equuli subsp. equuli, Actinobacillus equuli subsp. equuli
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