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hemF hemF hemH hemH cobQ cobQ Sde_0629 Sde_0629 cobT cobT cobS cobS Sde_0632 Sde_0632 Sde_0654 Sde_0654 hemL hemL Sde_0831 Sde_0831 Sde_1084 Sde_1084 Sde_1473 Sde_1473 Sde_1663 Sde_1663 Sde_1664 Sde_1664 Sde_1668 Sde_1668 Sde_1669 Sde_1669 cysG cysG cysS cysS Sde_2013 Sde_2013 Sde_2014 Sde_2014 Sde_2015 Sde_2015 cysC cysC cysN cysN cysD cysD Sde_2239 Sde_2239 Sde_2356 Sde_2356 Sde_2483 Sde_2483 Sde_2675 Sde_2675 orn orn Sde_2678 Sde_2678 psd psd hemE hemE Sde_2901 Sde_2901 Sde_3202 Sde_3202 Sde_3203 Sde_3203 Sde_3204 Sde_3204 Sde_3205 Sde_3205 hemA hemA cysQ cysQ Sde_3663 Sde_3663 Sde_3664 Sde_3664 Sde_3665 Sde_3665 Sde_3666 Sde_3666 hemC hemC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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textmining
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Your Input:
hemFCoproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (303 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (371 aa)
cobQAdenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (485 aa)
Sde_0629Corrinoid adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (217 aa)
cobTNicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (347 aa)
cobSCobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (302 aa)
Sde_0632Phosphoglycerate mutase. (177 aa)
Sde_0654Porphobilinogen synthase; Belongs to the ALAD family. (333 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (423 aa)
Sde_0831Conserved hypothetical protein 701. (141 aa)
Sde_1084Serine O-acetyltransferase. (277 aa)
Sde_1473Flavodoxin/nitric oxide synthase. (149 aa)
Sde_1663Pyridoxal phosphate-dependent deaminase. (336 aa)
Sde_1664Amino acid carrier protein. (452 aa)
Sde_1668Conserved hypothetical protein. (111 aa)
Sde_1669Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. (241 aa)
cysGuroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (458 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (459 aa)
Sde_2013Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. (554 aa)
Sde_2014Uncharacterised conserved protein UCP030820. (165 aa)
Sde_2015Sodium/hydrogen exchanger. (388 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (471 aa)
cysDSulfate adenylyltransferase subunit 2. (303 aa)
Sde_2239Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (296 aa)
Sde_2356uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (262 aa)
Sde_2483Oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (484 aa)
Sde_2675Major facilitator superfamily MFS_1. (411 aa)
ornExonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (181 aa)
Sde_2678Rhodanese-like protein. (276 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (286 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
Sde_2901Cysteine synthase. (317 aa)
Sde_3202ABC transporter related. (254 aa)
Sde_3203Transport system permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (354 aa)
Sde_3204Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa)
Sde_3205Periplasmic binding protein. (309 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (425 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (271 aa)
Sde_3663Hypothetical protein. (175 aa)
Sde_3664Metal dependent phosphohydrolase. (403 aa)
Sde_3665Protein of unknown function DUF513, hemX. (494 aa)
Sde_3666Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (290 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (308 aa)
Your Current Organism:
Saccharophagus degradans
NCBI taxonomy Id: 203122
Other names: Microbulbifer degradans 2-40, Microbulbifer sp. 2-40, S. degradans 2-40, Saccharophagus degradans 2-40, Saccharophagus degradans ATCC 43961, Saccharophagus degradans str. 2-40, Saccharophagus degradans strain 2-40, bacterium 2-40
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