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thyA thyA udp udp YPO3650 YPO3650 YPO3590 YPO3590 pyrI pyrI pyrB pyrB cpdB cpdB nrdD nrdD YPO3378 YPO3378 pyrG pyrG surE surE ppnP ppnP tgt tgt nrdR nrdR ybbO ybbO hcaT hcaT YPO2884 YPO2884 ndk ndk YPO2873 YPO2873 upp upp nrdI nrdI nrdE nrdE nrdF nrdF YPO2559 YPO2559 YPO2295 YPO2295 pyrF pyrF tdk tdk YPO1669 YPO1669 tmk tmk b1062 b1062 b2065 b2065 b2066 b2066 cdd cdd rlmI rlmI rlmL rlmL pyrD pyrD cmk cmk YPO1226 YPO1226 dnaF dnaF ftsB ftsB YPO1179 YPO1179 pyrH pyrH YPO1033 YPO1033 YPO0995 YPO0995 YPO0936 YPO0936 YPO0627 YPO0627 b0033 b0033 b0032 b0032 b4384 b4384 crpB crpB codA codA YPO0141 YPO0141 dnaS dnaS pyrE pyrE YPO0009 YPO0009
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
YPO3650Putative metabolite transport protein; Similar to Escherichia coli proline/betaine transporter ProP SW:PROP_ECOLI (P30848) (500 aa) fasta scores: E(): 5.9e-26, 27.4% id in 449 aa. (454 aa)
YPO3590Conserved hypothetical protein; Similar to Salmonella typhimurium YjgF protein TR:Q9X445 (EMBL:AF095578) (128 aa) fasta scores: E(): 0,85.9% id in 128 aa, and to Escherichia coli hypothetical protein YjgF SW:YJGF_ECOLI (P39330) (127 aa) fasta scores: E(): 0, 84.9% id in 126 aa. Similar to YPO1669 (55.4% identity in 121 aa overlap) and to YPO0627 (48.4% identity in 126 aa overlap). (128 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa)
pyrBSimilar to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 84.8% id in 310 aa,and to Erwinia herbicola aspartate transcarbamylase catalytic subunit PyrB TR:Q9RMS8 (EMBL:AF190426) (311 aa) fasta scores: E(): 0, 85.9% id in 311 aa. (311 aa)
cpdBSimilar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor CpdB SW:CN16_ECOLI (P08331) (647 aa) fasta scores: E(): 0, 76.0% id in 646 aa, and to Yersinia enterocolitica 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor CpdB SW:CN16_YEREN (P53052) (652 aa) fasta scores: E(): 0, 91.3% id in 652 aa; Belongs to the 5'-nucleotidase family. (656 aa)
nrdDSimilar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase NrdD SW:NRDD_ECOLI (P28903) (712 aa) fasta scores: E(): 0, 86.0% id in 709 aa,and to Salmonella typhimurium anaerobic ribonucleoside-triphosphate reductase NrdD TR:Q9L646 (EMBL:AF242390) (712 aa) fasta scores: E(): 0, 87.2% id in 709 aa. (712 aa)
YPO3378Similar to Escherichia coli hypothetical protein MazG SW:MAZG_ECOLI (P33646) (263 aa) fasta scores: E(): 0,72.6% id in 266 aa, and to Vibrio cholerae MazG protein VC2450 TR:Q9KPC2 (EMBL:AE004315) (278 aa) fasta scores: E(): 0, 56.0% id in 268 aa. (280 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
surEStationary-phase survival protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (254 aa)
ppnPConserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (95 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (374 aa)
nrdRConserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa)
ybbOProbable short-chain dehydrogenase; Similar to Escherichia coli hypothetical oxidoreductase in ushA-tesA intergenic region YbbO SW:YBBO_ECOLI (P77388) (269 aa) fasta scores: E(): 0, 68.4% id in 256 aa, and to Vibrio cholerae oxidoreductase,short-chain dehydrogenase/reductase family Vc0979 TR:Q9KTC3 (EMBL:AE004179) (275 aa) fasta scores: E(): 0, 46.9% id in 271 aa; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)
hcaTPutative transport permease protein; Similar to Bacillus stearothermophilus maltose permease MalA SW:MALA_BACST (Q45632) (394 aa) fasta scores: E(): 4.2e-12, 26.1% id in 379 aa, and to Escherichia coli probable 3-phenylpropionic acid transporter HcaT SW:HCAT_ECOLI (Q47142) (379 aa) fasta scores: E(): 0, 66.6% id in 377 aa. (385 aa)
YPO2884Putative exported protein; No significant database matches. (806 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
YPO2873Similar to Vibrio cholerae hypothetical protein VC0765 TR:Q9KTW5 (EMBL:AE004162) (77 aa) fasta scores: E(): 5e-09, 36.5% id in 74 aa, and to C-terminal region of Escherichia coli hypothetical protein YfgJ SW:YFGJ_ECOLI (P76575) (83 aa) fasta scores: E(): 4.8e-16, 64.1% id in 64 aa. (74 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
nrdINrdI protein homologue; Probably involved in ribonucleotide reductase function. (134 aa)
nrdERibonucleoside-diphosphate reductase 2 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (693 aa)
nrdFRibonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
YPO2559Conserved hypothetical protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (197 aa)
YPO2295Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. (224 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa)
tdkThymidine kinase; Similar to Escherichia coli thymidine kinase Tdk SW:KITH_ECOLI (P23331) (205 aa) fasta scores: E(): 0, 76.4% id in 191 aa, and to Vibrio cholerae thymidine kinase VC1167 TR:Q9KST9 (EMBL:AE004197) (192 aa) fasta scores: E(): 0, 72.6% id in 190 aa. (196 aa)
YPO1669YjgF-family lipoprotein; Similar to Salmonella typhimurium YjgF TR:Q9X445 (EMBL:AF095578) (128 aa) fasta scores: E(): 1.1e-21, 54.5% id in 121 aa, and to Escherichia coli protein YjgF SW:YJGF_ECOLI (P39330) (127 aa) fasta scores: E(): 8e-22,55.4% id in 121 aa. Similar to YPO3590 (55.4% identity in 121 aa overlap). In S. typhimurium YjgF mutants do not require the pentose phosphate pathway for the function of the alternative pyrimidine biosynthetic pathway. J Bacteriol 1998, 180(24):6519-28. (125 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. 5-bromo-2'deoxyuridine monophosphate is also a good phosphate acceptor; Belongs to the thymidylate kinase family. (212 aa)
b1062Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
b2065Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
b2066Uridine kinase; Similar to Escherichia coli uridine kinase SW:URK_ECOLI (P31218) (213 aa) fasta scores: E(): 0, 91.1% id in 213 aa, and to Vibrio cholerae uridine kinase vc1038 TR:Q9KT67 (EMBL:AE004185) (219 aa) fasta scores: E(): 0,75.0% id in 208 aa. (213 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
rlmIConserved hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (396 aa)
rlmLConserved hypothetical protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (706 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
cmkCytidylate kinase; Similar to Escherichia coli cytidylate kinase Cmk SW:KCY_ECOLI (P23863) (227 aa) fasta scores: E(): 0, 84.5% id in 226 aa, and to Vibrio cholerae cytidylate kinase VC1916 TR:Q9KQT2 (EMBL:AE004267) (229 aa) fasta scores: E(): 0, 67.0% id in 224 aa. (230 aa)
YPO1226Putative transport protein; Weakly similar to many sugar transporters eg. Escherichia coli melibiose carrier protein MelB SW:MELB_ECOLI (P02921) (469 aa) fasta scores: E(): 7.4e-13,23.6% id in 478 aa. (498 aa)
dnaFRibonucleoside-diphosphate reductase 1 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (762 aa)
ftsBSimilar to Escherichia coli ribonucleoside-diphosphate reductase 1 beta chain NrdB or FtsB SW:RIR2_ECOLI (P00453) (375 aa) fasta scores: E(): 0,88.3% id in 375 aa, and to Bacteriophage T4 ribonucleoside-diphosphate reductase beta chain NrdB SW:RIR2_BPT4 (P11156) (388 aa) fasta scores: E(): 0, 51.4% id in 385 aa. (376 aa)
YPO1179Similar to Escherichia coli hypothetical protein YajD SW:YAJD_ECOLI (P19678) (109 aa) fasta scores: E(): 0,84.7% id in 98 aa. (113 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
YPO1033Similar to Escherichia coli hypothetical protein YgdH SW:YGDH_ECOLI (P37350) (454 aa) fasta scores: E(): 0,82.6% id in 454 aa, and to Vibrio cholerae hypothetical protein VC0899 TR:Q9KTK3 (EMBL:AE004173) (457 aa) fasta scores: E(): 0, 69.9% id in 455 aa. (454 aa)
YPO0995Sodium:galactoside symporter family protein; Similar to Salmonella typhimurium melibiose permease MelB SW:MELB_SALTY (P30878) (476 aa) fasta scores: E(): 8.4e-25, 31.3% id in 451 aa, and to Bacillus subtilis hypothetical symporter YnaJ SW:YNAJ_BACSU (P94488) (463 aa) fasta scores: E(): 0, 31.5% id in 445 aa. (477 aa)
YPO0936Conserved hypothetical protein; Similar to Escherichia coli protein YqgE SW:YQGE_ECOLI (P52049) (187 aa) fasta scores: E(): 0, 66.8% id in 187 aa, and to Vibrio cholerae hypothetical protein VC0467 TR:Q9KUP8 (EMBL:AE004133) (200 aa) fasta scores: E(): 0, 51.6% id in 190 aa; Belongs to the UPF0301 (AlgH) family. (187 aa)
YPO0627Similar to Homo sapiens translational inhibitor protein YER057c/YJGF SW:UK14_HUMAN (P52758) (137 aa) fasta scores: E(): 1.9e-18, 45.2% id in 124 aa, and to Bacillus halodurans possible translation initiation inhibitor BH0063 TR:Q9KGJ8 (EMBL:AP001507) (124 aa) fasta scores: E(): 6e-21, 53.2% id in 126 aa. CDS DNA has a low G+C content,35.43%. Possible horizontally acquired gene. (126 aa)
b0033Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB SW:CARB_ECOLI (P00968) (1072 aa) fasta scores: E(): 0, 92.6% id in 1072 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase large chain CarB SW:CARB_SALTY (P14846) (1074 aa) fasta scores: E(): 0, 92.7% id in 1072 aa. (1077 aa)
b0032Similar to Escherichia coli carbamoyl-phosphate synthase small chain CarA SW:CARA_ECOLI (P00907) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase small chain CarA SW:CARA_SALTY (P14845) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa; Belongs to the CarA family. (391 aa)
b4384Similar to Escherichia coli purine nucleoside phosphorylase DeoD SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 91.1% id in 236 aa, and to Klebsiella pneumoniae purine nucleoside phosphorylase DeoD SW:DEOD_KLEPN (Q59482) (239 aa) fasta scores: E(): 0, 88.7% id in 238 aa. (239 aa)
crpB10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
codASimilar to Escherichia coli cytosine deaminase CodA SW:CODA_ECOLI (P25524) (426 aa) fasta scores: E(): 0, 80.5% id in 425 aa. (436 aa)
YPO0141Similar to Escherichia coli hypothetical protein YrfG SW:YRFG_ECOLI (P45801) (222 aa) fasta scores: E(): 0,67.0% id in 221 aa. (226 aa)
dnaSDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)
YPO0009Putative membrane transport protein; Similar to many proteins belonging to the major facilitator family of drug resistance translocases e.g. Neisseria gonorrhoeae efflux transporter membrane protein AgrA TR:BAB13740 (EMBL:AB032563) (468 aa) fasta scores: E(): 0, 45.4% id in 460 aa Also highly similar to Escherichia coli hypothetical 51.5 kDa protein in rbsr-rrsc intergenic region yieO SW:YIEO_ECOLI (P31474) (475 aa) fasta scores: E(): 0, 74.2% id in 457 aa. (474 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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