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rpmA rpmA rsmG rsmG rlmN rlmN rplS rplS KGL13508.1 KGL13508.1 mnmA mnmA chuR chuR rlmH rlmH tgt tgt rpmH rpmH pheT pheT pheS pheS KGL13324.1 KGL13324.1 KGL13313.1 KGL13313.1 KGL13310.1 KGL13310.1 rsmH rsmH rplY rplY rpmE rpmE rsmI rsmI trmU trmU rluD rluD hypC hypC rpsT rpsT prfA prfA KGL13182.1 KGL13182.1 rpsA rpsA ksgA ksgA gltX_1 gltX_1 infA infA rplO rplO rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ fusA fusA rpsG rpsG rpsL rpsL rpoBC rpoBC rplL rplL rplJ rplJ rplA rplA rplK rplK nusG nusG rpmG rpmG tuf tuf cmoB cmoB cysS cysS gltX_2 gltX_2 rpsP rpsP rimM rimM rpoZ rpoZ tyrS tyrS trmD trmD truA truA rpsO rpsO KGL13804.1 KGL13804.1 tilS tilS KGL13786.1 KGL13786.1 rluB rluB rpoD rpoD rplQ rplQ rpoA rpoA rpsD rpsD rpsM rpsM hypE hypE hypA hypA ydiB ydiB rbfA rbfA gidA gidA rimO rimO glyS glyS yheS yheS moeB_1 moeB_1 thrS thrS infC infC rpmI rpmI rplT rplT rho rho queH queH lepB lepB trmL trmL cmoA cmoA smpB smpB nusA nusA gatC gatC hypD hypD KGL12698.1 KGL12698.1 KGL12699.1 KGL12699.1 KGL12700.1 KGL12700.1 fusA-2 fusA-2 KGL12703.1 KGL12703.1 KGL12704.1 KGL12704.1 KGL12705.1 KGL12705.1 KGL12706.1 KGL12706.1 KGL12707.1 KGL12707.1 KGL12708.1 KGL12708.1 KGL12709.1 KGL12709.1 KGL12710.1 KGL12710.1 KGL12712.1 KGL12712.1 tuf-2 tuf-2 KGL12755.1 KGL12755.1 gatB gatB KGL12733.1 KGL12733.1 lysS lysS hyaD hyaD proS proS tsf tsf rpsB rpsB truB truB rpoN rpoN rluA_2 rluA_2 fmt fmt fliA fliA KGL12454.1 KGL12454.1 rpsR rpsR KGL12438.1 KGL12438.1 rpsU rpsU rplI rplI prfB prfB KGL12427.1 KGL12427.1 alaS alaS trmE trmE lepA lepA KGL12369.1 KGL12369.1 aspS aspS KGL12697.1 KGL12697.1 KGL12696.1 KGL12696.1 KGL12695.1 KGL12695.1 KGL12694.1 KGL12694.1 KGL12693.1 KGL12693.1 rpmC rpmC KGL12691.1 KGL12691.1 KGL12690.1 KGL12690.1 rplX-2 rplX-2 KGL12688.1 KGL12688.1 rpsN-2 rpsN-2 KGL12686.1 KGL12686.1 KGL12685.1 KGL12685.1 KGL12684.1 KGL12684.1 KGL12683.1 KGL12683.1 KGL12682.1 KGL12682.1 infA-2 infA-2 miaB_2 miaB_2 rplM rplM rpsI rpsI rnc rnc serS serS ileS ileS argS argS gatA gatA metG metG rlmB rlmB hisS hisS frr frr leuS leuS KGL12885.1 KGL12885.1 def def rpmB rpmB glyQ glyQ htpX htpX trpS trpS infB infB rpmF rpmF KGL13380.1 KGL13380.1 rplU rplU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rpmA50S ribosomal protein L27; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
rsmGHypothetical protein; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (179 aa)
rlmN50S rRNA methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (367 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (124 aa)
KGL13508.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
mnmAATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
chuRHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
rlmHHypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (178 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (378 aa)
rpmH50S ribosomal protein L34; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL34 family. (45 aa)
pheTphenylalanine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (806 aa)
pheSphenylalanyl-tRNA synthetase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (330 aa)
KGL13324.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (81 aa)
KGL13313.1Hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (257 aa)
KGL13310.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
rsmHS-adenosyl-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (293 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (178 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (67 aa)
rsmIHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
trmUThiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (308 aa)
rluDPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RluA family. (346 aa)
hypCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (99 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (90 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (353 aa)
KGL13182.1Fibronectin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
rpsA30S ribosomal protein S1; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
ksgAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (272 aa)
gltX_1glutamate--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (456 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (74 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (137 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (146 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (181 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (74 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (226 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (118 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (93 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (204 aa)
rplC50S ribosomal protein L3; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (692 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (127 aa)
rpoBCDNA-directed RNA polymerase subunit beta/beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2887 aa)
rplL50S ribosomal protein L7; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (124 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (162 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (235 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
nusGAntitermination protein NusG; Participates in transcription elongation, termination and antitermination. (177 aa)
rpmG50S ribosomal protein L33; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL33 family. (57 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
cmoBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
cysScysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (483 aa)
gltX_2glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (482 aa)
rpsP30S ribosomal protein S16; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bS16 family. (76 aa)
rimMHypothetical protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (225 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (72 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (396 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (223 aa)
truAtRNA pseudouridine synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (250 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (91 aa)
KGL13804.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
tilSHypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (268 aa)
KGL13786.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
rluBPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (267 aa)
rpoDRNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (637 aa)
rplQ50S ribosomal protein L17; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (337 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (120 aa)
hypEHydrogenase assembly protein HupF; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (115 aa)
ydiBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
rbfARibosome-binding factor A; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
gidAGlucose-inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (666 aa)
rimORibosomal protein S12 methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (430 aa)
glySglycyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (731 aa)
yheSABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
moeB_1Thiamine biosynthesis protein ThiF; Catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
thrSthreonyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. (621 aa)
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (174 aa)
rpmI50S ribosomal protein L35; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (465 aa)
queHHypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (405 aa)
lepBSignal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family. (308 aa)
trmLHypothetical protein; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (191 aa)
cmoAHypothetical protein; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). (278 aa)
smpBSingle-stranded DNA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome t [...] (150 aa)
nusATranscription elongation factor NusA; Participates in both transcription termination and antitermination. (415 aa)
gatCglutamyl-tRNA amidotransferase; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (92 aa)
hypDHydrogenase formation protein HypD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family. (370 aa)
KGL12698.150S ribosomal protein L23; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
KGL12699.150S ribosomal protein L4; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
KGL12700.130S ribosomal protein S10; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
fusA-2Elongation factor G; EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; Derived by automated computational analysis using gene prediction method: Protein Homology. (692 aa)
KGL12703.130S ribosomal protein S7; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
KGL12704.130S ribosomal protein S12; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
KGL12705.1DNA-directed RNA polymerase subunit beta/beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; fusion of rpoB and rpoC; beta and beta' subunits are part of the catalytic core which binds with a sigma factor to produce the holoenzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (2887 aa)
KGL12706.150S ribosomal protein L7; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
KGL12707.150S ribosomal protein L10; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
KGL12708.150S ribosomal protein L1; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
KGL12709.150S ribosomal protein L11; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
KGL12710.1Antitermination protein NusG; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
KGL12712.150S ribosomal protein L33; Derived by automated computational analysis using gene prediction method: Protein Homology. (57 aa)
tuf-2Elongation factor Tu; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
KGL12755.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
gatBglutamyl-tRNA amidotransferase; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (475 aa)
KGL12733.1cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
lysSlysine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. (502 aa)
hyaDProtein hydD; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (574 aa)
tsfElongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (352 aa)
rpsB30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (275 aa)
truBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase TruB family. (304 aa)
rpoNRNA polymerase sigma54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (431 aa)
rluA_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
fmtHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
fliARNA polymerase sigma 70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (240 aa)
KGL12454.1glutamate--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (84 aa)
KGL12438.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
rpsU30S ribosomal protein S21; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bS21 family. (70 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (149 aa)
prfBPeptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (364 aa)
KGL12427.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TtcA family. (264 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (890 aa)
trmEtRNA modification GTPase mnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (463 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (597 aa)
KGL12369.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
aspSaspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (588 aa)
KGL12697.150S ribosomal protein L2; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
KGL12696.130S ribosomal protein S19; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
KGL12695.150S ribosomal protein L22; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
KGL12694.130S ribosomal protein S3; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
KGL12693.150S ribosomal protein L16; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
rpmC50S ribosomal protein L29; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL29 family. (65 aa)
KGL12691.130S ribosomal protein S17; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
KGL12690.150S ribosomal protein L14; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
rplX-250S ribosomal protein L24; Assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
KGL12688.150S ribosomal protein L5; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
rpsN-230S ribosomal protein S14; Located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; Derived by automated computational analysis using gene prediction method: Protein Homology. (61 aa)
KGL12686.130S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
KGL12685.150S ribosomal protein L6; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
KGL12684.150S ribosomal protein L18; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
KGL12683.130S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
KGL12682.150S ribosomal protein L15; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
infA-2Stimulates the activities of the other two initiation factors, IF-2 and IF-3; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
miaB_2(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (437 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
rpsI30S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (229 aa)
serSseryl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
ileSisoleucyl-tRNA synthase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (971 aa)
argSarginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
gatAglutamyl-tRNA amidotransferase; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (454 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (676 aa)
rlmBRNA methyltransferase TrmH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (234 aa)
hisShistidyl-tRNA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
frrRibosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
leuSleucyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (820 aa)
KGL12885.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (173 aa)
rpmB50S ribosomal protein L28; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL28 family. (65 aa)
glyQglycyl-tRNA synthetase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
htpXPeptidase M48; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (325 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (913 aa)
rpmF50S ribosomal protein L32; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL32 family. (49 aa)
KGL13380.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (106 aa)
Your Current Organism:
Helicobacter muridarum
NCBI taxonomy Id: 216
Other names: ATCC 49282, CCUG 29262, CIP 104248, DSM 22221, H. muridarum, LMG 13646, LMG:13646, NCTC 12714, strain ST1
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