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| | MMAR_0036 | DNA-binding protein. (135 aa) |
| | leuS | leucyl-tRNA synthetase LeuS; Involved in translation mechanism [catalytic activity: ATP + L-leucine + tRNA(leu) = AMP + diphosphate + L-leucyl-tRNA(leu)]; Belongs to the class-I aminoacyl-tRNA synthetase family. (976 aa) |
| | rpsF | 30S ribosomal protein S6 RpsF; Binds together with S18 to 16S ribosomal RNA. (96 aa) |
| | rpsR1 | 30S ribosomal protein S18-1 RpsR1; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (84 aa) |
| | rplI | 50S ribosomal protein L9 RplI; Binds to the 23S rRNA. (152 aa) |
| | rpsR2 | Ribosomal protein S18 RpsR2; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (87 aa) |
| | rpsN2 | Ribosomal protein S14 RpsN2; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpmG1 | Ribosomal protein L33 RpmG1; Involved in translation; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | rpmB2 | 50S ribosomal protein L28 RpmB2; Involved in ribosome activity; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | rpmE_1 | 50S ribosomal protein L31 RpmE_1; Involved in translation; Belongs to the bacterial ribosomal protein bL31 family. (90 aa) |
| | fusA2 | Elongation factor G FusA2; Involved in translation mechanism. this protein may promote the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. (718 aa) |
| | MMAR_0828 | Conserved hypothetical protein. (33 aa) |
| | rpmG2 | 50S ribosomal protein L33 type 2, RpmG2; Belongs to the bacterial ribosomal protein bL33 family. (55 aa) |
| | secE | Preprotein translocase (tail-anchored membrane protein), SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (162 aa) |
| | nusG | Transcription antitermination protein, NusG; Participates in transcription elongation, termination and antitermination. (237 aa) |
| | rplK | 50S ribosomal protein L11, RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa) |
| | rplA | 50S ribosomal protein L1, RplA; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (235 aa) |
| | rplJ | 50S ribosomal protein L10, RplJ; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (206 aa) |
| | rplL | 50S ribosomal protein L7/L12, RplL; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (130 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit, RpoB; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1176 aa) |
| | rpoC | DNA-directed RNA polymerase, beta chain, RpoC; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1316 aa) |
| | rpsL | 30S ribosomal protein S12, RpsL; With S4 and S5 plays an important role in translational accuracy. (124 aa) |
| | rpsG | 30S ribosomal protein S7, RpsG; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA1 | Elongation factor G, FusA1; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (701 aa) |
| | tuf | Iron-regulated elongation factor Ef-tu, Tuf; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa) |
| | rpsJ | 30S ribosomal protein S10, RpsJ; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (101 aa) |
| | rplC | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (217 aa) |
| | rplD | 50S ribosomal protein L4, RplD; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (224 aa) |
| | rplW | 50S ribosomal protein L23, RplW; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa) |
| | rplB | 50S ribosomal protein L2, RplB; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa) |
| | rpsS | 50S ribosomal protein S19, RpsS; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa) |
| | rplV | 50S ribosomal protein L22, RplV; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (176 aa) |
| | rpsC | 30S ribosomal protein S3, RpsC; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (275 aa) |
| | rplP | 50S ribosomal protein L16, RplP; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa) |
| | rpmC | 50S ribosomal protein L29, RpmC; Involved in translation; Belongs to the universal ribosomal protein uL29 family. (80 aa) |
| | rpsQ | 30S ribosomal protein S17, RpsQ; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (119 aa) |
| | rplN | 50S ribosomal protein L14, RplN; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | 50S ribosomal protein L24, RplX; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (107 aa) |
| | rplE | 50S ribosomal protein L5, RplE; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (190 aa) |
| | rpsN | 30S ribosomal protein S14, RpsN; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | 30S ribosomal protein S8, RpsH; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rplF | 50S ribosomal protein L6, RplF; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa) |
| | rplR | 50S ribosomal protein L18, RplR; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (135 aa) |
| | rpsE | 30S ribosomal protein S5, RpsE; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (224 aa) |
| | rpmD | 50S ribosomal protein L30, RpmD. (72 aa) |
| | rplO | 50S ribosomal protein L15, RplO; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | secY | Preprotein translocase, SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (441 aa) |
| | infA | Translation initiation factor IF-1, InfA; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa) |
| | rpmJ | 50S ribosomal protein L36 RpmJ; Ribosome function; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | 30S ribosomal protein S13, RpsM; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (124 aa) |
| | rpsK | 30S ribosomal protein S11, RpsK; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (138 aa) |
| | rpsD | 30S ribosomal protein S4, RpsD; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa) |
| | rpoA | DNA-directed RNA polymerase (alpha chain), RpoA; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa) |
| | rplQ | 50S ribosomal protein L17, RplQ; Involved in translation mechanism. (189 aa) |
| | rplM | 50S ribosomal protein L13, RplM; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa) |
| | rpsI | Ribosomal protein S9, RpsI; Involved in translation mechanism. this protein is one of the assembly proteins of the 50S ribosomal subunit; Belongs to the universal ribosomal protein uS9 family. (152 aa) |
| | MMAR_1128 | Conserved hypothetical membrane protein. (145 aa) |
| | hpf | Conserved protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (229 aa) |
| | secA1 | Preprotein translocase SecA1 1 subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (950 aa) |
| | whiB7 | Transcriptional regulatory protein Whib-like WhiB7; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (91 aa) |
| | gltS | glutamyl-tRNA synthetase GltS; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (489 aa) |
| | rpmB2_1 | 50S ribosomal protein L28 RpmB2_1; Involved in ribosome activity; Belongs to the bacterial ribosomal protein bL28 family. (64 aa) |
| | ftsY | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (458 aa) |
| | ffh | Signal recognition particle protein Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (529 aa) |
| | rpsP | 30S ribosomal protein S16 RpsP; Involved in translation mechanism; Belongs to the bacterial ribosomal protein bS16 family. (161 aa) |
| | rimM | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (174 aa) |
| | trmD | tRNA (guanine-N1)-methyltransferase TrmD; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (230 aa) |
| | rplS | 50S ribosomal protein L19 RplS; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (113 aa) |
| | lepB | Signal peptidase I LepB; Cleavage of N-terminal leader sequences from secreted protein precursors; Belongs to the peptidase S26 family. (287 aa) |
| | rnhB | Ribonuclease HII protein RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (239 aa) |
| | rpsB | 30S ribosomal protein S2 RpsB; Involved in translation mechanism; Belongs to the universal ribosomal protein uS2 family. (276 aa) |
| | tsf | Elongation factor Tsf; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (271 aa) |
| | pyrH | Uridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (265 aa) |
| | frr | Ribosome recycling factor Frr; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | mapB | Methionine aminopeptidase MapB; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (285 aa) |
| | proS | prolyl-tRNA synthetase ProS; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involve [...] (582 aa) |
| | rimP | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (177 aa) |
| | nusA | N utilization substance protein a NusA; Participates in both transcription termination and antitermination. (347 aa) |
| | MMAR_1893 | Conserved hypothetical protein. (126 aa) |
| | infB | Translation initiation factor IF-2 InfB; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (947 aa) |
| | rbfA | Ribosome-binding factor a RbfA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (175 aa) |
| | MMAR_1896 | Conserved hypothetical protein. (324 aa) |
| | dinF | DNA-damage-inducible protein F DinF; Function unknown, induction by DNA damage. (445 aa) |
| | rpsO | 30S ribosomal protein S15 RpsO; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | hflX | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (504 aa) |
| | ideR | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. (230 aa) |
| | sigB | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (333 aa) |
| | sigA | RNA polymerase sigma factor SigA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (501 aa) |
| | yajC | Conserved membrane protein secretion factor YajC; Thought to be involved in secretion apparatus. (113 aa) |
| | secD | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (615 aa) |
| | secF | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (446 aa) |
| | hisS | histidyl-tRNA synthetase HisS; Involved in translation mechamism [catalytic activity: ATP + L-histidine + tRNA(his) = AMP + pyrophosphate + l-histidyl-tRNA(his)]. (420 aa) |
| | efp | Elongation factor P Efp; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (187 aa) |
| | nusB | N utilization substance protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (173 aa) |
| | mihF | Integration host factor MihF. (111 aa) |
| | rpoZ | DNA-directed RNA polymerase (omega chain) RpoZ; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (110 aa) |
| | secG | Protein-export membrane protein (translocase subunit) SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (77 aa) |
| | MMAR_2325 | Conserved hypothetical protein. (212 aa) |
| | ileS | isoleucyl-tRNA synthetase IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1066 aa) |
| | MMAR_2362 | Pseudouridine synthase, RluA-family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (303 aa) |
| | lysX | lysyl-tRNA synthetase 2 LysX; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lys [...] (1097 aa) |
| | infC | Initiation factor IF-3 InfC; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (167 aa) |
| | rpmL | 50S ribosomal protein L35, RpmL; Translation; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | rplT | 50S ribosomal protein L20 RplT; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (129 aa) |
| | tsnR | 23S rRNA methyltransferase TsnR; rRNA modification; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (275 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha chain PheS; Charging Phe tRNA [catalytic activity : ATP + L- phenylalanine + tRNA(Phe) = AMP + diphosphate + L- phenylalanyl-tRNA(Phe)]; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (347 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta chain PheT; Charging phe-tRNA [catalytic activity : ATP + L- phenylalanine + tRNA(Phe) = AMP + diphosphate + L- phenylalanyl-tRNA(Phe)]; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (829 aa) |
| | MMAR_2578 | Metal cation transporter p-type ATPase a, CtpF; Metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]. (818 aa) |
| | secA2 | Preprotein translocase ATPase SecA2; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (806 aa) |
| | MMAR_2900 | Iron-regulated elongation factor tu Tuf-like protein; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. (86 aa) |
| | rbpA | Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family. (101 aa) |
| | tatC | Sec-independent protein translocase transmembrane protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (317 aa) |
| | tatA | Sec-independent protein translocase membrane- bound protein, TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (88 aa) |
| | rpsT | 30S ribosomal protein S20 RpsT; Binds directly to 16S ribosomal RNA. (87 aa) |
| | rsfS | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (129 aa) |
| | obg | GTP1/OBG-family GTP-binding protein Obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (479 aa) |
| | rpmA | 50S ribosomal protein L27 RpmA; Involved in translation mechanisms; Belongs to the bacterial ribosomal protein bL27 family. (88 aa) |
| | rplU | 50S ribosomal protein L21 RplU; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | tig | Trigger factor (TF) protein Tig; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (484 aa) |
| | atpC | ATP synthase epsilon chain AtpC; Produces ATP from ADP in the presence of a proton gradient across the membrane. (121 aa) |
| | atpD | ATP synthase beta chain AtpD; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (483 aa) |
| | atpG | ATP synthase gamma chain AtpG; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (304 aa) |
| | atpA | ATP synthase alpha chain AtpA; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (549 aa) |
| | atpH | ATP synthase delta chain AtpH; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (445 aa) |
| | atpF | ATP synthase B chain AtpF; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (170 aa) |
| | atpE | ATP synthase C chain AtpE; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpB | ATP synthase a chain AtpB; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (250 aa) |
| | rpmE | 50S ribosomal protein L31 RpmE; Binds the 23S rRNA. (81 aa) |
| | argS | arginyl-tRNA synthetase ArgS; Involved in translation mechanism [catalytic activity: ATP + L-arginine + tRNA(arg) = AMP + diphosphate + L-arginyl-tRNA(arg)]. (550 aa) |
| | tatB | Involved in proteins export. this sec-independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity). (121 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (164 aa) |
| | rplY | 50S ribosomal protein L25 RplY; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (214 aa) |
| | ksgA | Dimethyladenosine transferase KsgA; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (274 aa) |
| | rpfB | Resuscitation-promoting factor RpfB; Thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulates the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis. (362 aa) |
| | tatD | Deoxyribonuclease TatD; DNAse involved in proteins export. this sec- independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity). (282 aa) |
| | metS | methionyl-tRNA synthetase MetS; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (518 aa) |
| | rpmF | 50S ribosomal protein L32 RpmF; Involved in translation mechanism; Belongs to the bacterial ribosomal protein bL32 family. (57 aa) |
| | MMAR_5061 | Conserved hypothetical secreted protein. (135 aa) |
| | MMAR_5079 | tRNA/rRNA methyltransferase; Function unknown role in tRNA and rRNA base modification by methylation; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (310 aa) |
| | cysS1 | cysteinyl-tRNA synthetase 1 CysS1; Involved in translation [catalytic activity: ATP + L-cysteine + tRNA(Cys) = AMP + pyrophosphate + L-cysteinyl- tRNA(Cys)]; Belongs to the class-I aminoacyl-tRNA synthetase family. (468 aa) |
| | MMAR_5083 | Conserved transcriptional regulatory protein; Function unknown role in regulation. (162 aa) |
| | lysS | lysyl-tRNA synthetase 1 LysS; Involved in translation [catalytic activity: ATP + L-lysine + tRNA(lys) = AMP + pyrophosphate + L-lysyl- tRNA(lys)]; Belongs to the class-II aminoacyl-tRNA synthetase family. (498 aa) |
| | ppa | Inorganic pyrophosphatase Ppa; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (162 aa) |
| | selB | Selenocysteine-specific translation elongation factor, SelB; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. (571 aa) |
| | serS | seryl-tRNA synthetase SerS; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (419 aa) |
| | rpmH | 50S ribosomal protein L34 RpmH; Involved in translation mechanism. this protein is one of the early assembly proteins of the 50S ribosomal subunit; Belongs to the bacterial ribosomal protein bL34 family. (47 aa) |
