(14 nodes) Helix_turn_helix, Lux Regulon, and Histidine kinase network (Mycobacterium marinum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMAR_0132	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain. (220 aa)
	MMAR_0133	Sensor part of the two-component regulatory system. (364 aa)
	devR	Regulator part of the two-component regulatory system DevR/DevS. controls HspX\|Acr expression. (216 aa)
	devS	Sensor part of the two-component regulatory system DevR/DevS. thought to control HspX\|Acr expression. (585 aa)
	MMAR_2876	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators. (395 aa)
	MMAR_3479	Sensor part of a two-component regulatory system. (549 aa)
	MMAR_3480	Regulator part of a two-component regulatory system. (217 aa)
	argE	Acetylornithine deacetylase ArgE; Deacetylates acetylornithine and hydrolyses N- acetylmethionine. (441 aa)
	MMAR_3958	Two-component sensor kinase; Involved in unknown signal transduction mechanism. (380 aa)
	MMAR_3959	Regulator part of the two-component regulatory system. (218 aa)
	MMAR_3960	Conserved hypothetical protein. (621 aa)
	MMAR_4781	Possible sensor part of a two-component regulatory system. (405 aa)
	narL	Nitrate/nitrite response regulator protein NarL. (216 aa)
	MMAR_4783	Possible sensor part of a two-component regulatory system. (513 aa)

Your Current Organism:

Mycobacterium marinum

NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMAR_0132	MMAR_0133	MMAR_0132	MMAR_0133	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Sensor part of the two-component regulatory system.	0.884
MMAR_0132	MMAR_2876	MMAR_0132	MMAR_2876	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	0.681
MMAR_0132	MMAR_3479	MMAR_0132	MMAR_3479	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Sensor part of a two-component regulatory system.	0.897
MMAR_0132	MMAR_3958	MMAR_0132	MMAR_3958	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Two-component sensor kinase; Involved in unknown signal transduction mechanism.	0.517
MMAR_0132	MMAR_4781	MMAR_0132	MMAR_4781	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Possible sensor part of a two-component regulatory system.	0.883
MMAR_0132	MMAR_4783	MMAR_0132	MMAR_4783	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Possible sensor part of a two-component regulatory system.	0.884
MMAR_0132	devS	MMAR_0132	MMAR_1517	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Sensor part of the two-component regulatory system DevR/DevS. thought to control HspX\|Acr expression.	0.880
MMAR_0132	narL	MMAR_0132	MMAR_4782	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Nitrate/nitrite response regulator protein NarL.	0.924
MMAR_0133	MMAR_0132	MMAR_0133	MMAR_0132	Sensor part of the two-component regulatory system.	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	0.884
MMAR_0133	MMAR_2876	MMAR_0133	MMAR_2876	Sensor part of the two-component regulatory system.	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	0.789
MMAR_0133	MMAR_3480	MMAR_0133	MMAR_3480	Sensor part of the two-component regulatory system.	Regulator part of a two-component regulatory system.	0.876
MMAR_0133	MMAR_3959	MMAR_0133	MMAR_3959	Sensor part of the two-component regulatory system.	Regulator part of the two-component regulatory system.	0.854
MMAR_0133	MMAR_4781	MMAR_0133	MMAR_4781	Sensor part of the two-component regulatory system.	Possible sensor part of a two-component regulatory system.	0.762
MMAR_0133	MMAR_4783	MMAR_0133	MMAR_4783	Sensor part of the two-component regulatory system.	Possible sensor part of a two-component regulatory system.	0.765
MMAR_0133	devR	MMAR_0133	MMAR_1516	Sensor part of the two-component regulatory system.	Regulator part of the two-component regulatory system DevR/DevS. controls HspX\|Acr expression.	0.877
MMAR_0133	devS	MMAR_0133	MMAR_1517	Sensor part of the two-component regulatory system.	Sensor part of the two-component regulatory system DevR/DevS. thought to control HspX\|Acr expression.	0.471
MMAR_0133	narL	MMAR_0133	MMAR_4782	Sensor part of the two-component regulatory system.	Nitrate/nitrite response regulator protein NarL.	0.876
MMAR_2876	MMAR_0132	MMAR_2876	MMAR_0132	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	0.681
MMAR_2876	MMAR_0133	MMAR_2876	MMAR_0133	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	Sensor part of the two-component regulatory system.	0.789
MMAR_2876	MMAR_3479	MMAR_2876	MMAR_3479	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	Sensor part of a two-component regulatory system.	0.843