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| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (546 aa) |
| | thiD | Phosphomethylpyrimidine kinase ThiD; Involved in thiamine biosynthesis. catalyzes the phosphorylation of HMP-P to HMP-PP [catalytic activity: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4- amino-2-methyl-5-diphosphomethylpyrimidine]. (275 aa) |
| | thiG | Thiamin biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa) |
| | thiS | Part of the thiamine biosynthesis operon. ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. It is coded in the THICEFSGH operon in E. coli. (65 aa) |
| | thiO | Involved in thiamine biosynthesis. (339 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (220 aa) |
| | ackA | Acetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (388 aa) |
| | pta | Phosphate acetyltransferase Pta; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (694 aa) |
| | fadE7 | acyl-CoA dehydrogenase FadE7; Function unknown, but involved in lipid degradation. (395 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (445 aa) |
| | purA | Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | cya_1 | Membrane-anchored adenylyl cyclase Cya_1; Involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. (441 aa) |
| | upp | Uracil phosphoribosyltransferase Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AirC); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (404 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AirC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | tmk | Thymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (217 aa) |
| | pvdS | Transcriptional regulatory protein PvdS; Possibly involved in transcriptional mechanism (probably sigma factor promoting attachment of the RNA polymerase to specific initiation sites). (290 aa) |
| | MMAR_1339 | Conserved hypothetical protein. (321 aa) |
| | MMAR_1384 | Conserved hypothetical protein. (244 aa) |
| | cyaA_1 | Adenylate cyclase, CyaA_1; Possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. (242 aa) |
| | MMAR_1604 | Conserved hypothetical membrane protein; Function unknown but contains Cdd pfam03982, DAGAT, diacylglycerol acyltransferase domain. (296 aa) |
| | nrdF2 | Ribonucleoside-diphosphate reductase (beta chain) NrdF2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa) |
| | MMAR_1687 | Conserved hypothetical membrane protein. (278 aa) |
| | gpdA2 | Glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2; Involved in de novo phospholipid biosynthesis; glycerol-3 phosphate formation [catalytic activity: SN- glycerol 3-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (335 aa) |
| | thiL | Thiamine-monophosphate kinase ThiL; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (321 aa) |
| | kdtB | Phosphopantetheine adenylyltransferase KdtB; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (157 aa) |
| | purU | Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (298 aa) |
| | fdhD | Formate dehydrogenase family accessory protein, FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (273 aa) |
| | MMAR_5379 | Acyltransferase; Function unknown, probably involved in cellular metabolism. (259 aa) |
| | MMAR_5378 | Acyltransferase; Function unknown, probably involved in cellular metabolism. (251 aa) |
| | MMAR_5377 | Acyltransferase; Function unknown, probably involved in cellular metabolism. (261 aa) |
| | MMAR_5273 | Conserved hypothetical membrane protein. (268 aa) |
| | MMAR_5270 | Conserved hypothetical protein. (160 aa) |
| | MMAR_5257 | Membrane-anchored adenylyl cyclase; Involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase. (1058 aa) |
| | MMAR_5254 | Membrane-anchored adenylyl cyclase; Involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase. (1056 aa) |
| | MMAR_5172 | Conserved membrane protein; Function unknown, contains metallophosphoesterase domain. (337 aa) |
| | acs | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa) |
| | MMAR_5137 | Adenylate cyclase; C-term contains an adenylyl/guanylyl cyclase domain. may catalyze the formation of cyclic AMP/GMP from ATP/GTP. (529 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase Hpt; Involved in purine salvage [catalytic activity: imp + pyrophosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (guanine can replace hypoxanthine to produce GMP)]; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (202 aa) |
| | folE | GTP cyclohydrolase I FolE; Involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + -amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyldihydropteridine triphosphate]. (202 aa) |
| | coaX | Conserved protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (272 aa) |
| | idsA1 | Multifunctional geranylgeranyl pyrophosphate synthetase IdsA1; Involved in the biosynthesis of membrane ether- linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [catalytic activity1: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate] [catalytic activity2: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans- farnesyl diphosphate] [catalytic activity3: trans-trans- farnesyl diphosphate + isopentenyl diphosphate [...] (346 aa) |
| | MMAR_1824 | Conserved hypothetical membrane protein. (316 aa) |
| | pyrH | Uridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (265 aa) |
| | MMAR_1216 | Acid phosphatase; Involved in cellular metabolism: acting on ester bonds [catalytic activity: an orthophosphoric monoester + H(2)O = an alcohol + orthophosphate]. (295 aa) |
| | cdsA | Integral membrane phosphatidate cytidylyltransferase CdsA; Involved in the phospholipid biosynthesis [catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol]; Belongs to the CDS family. (304 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (402 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (387 aa) |
| | MMAR_1860 | Conserved hypothetical sugar phosphate isomerase. (224 aa) |
| | MMAR_1861 | Conserved hypothetical protein. (240 aa) |
| | ribF | Bifunctional fad synthetase/riboflavin biosynthesis protein RibF; Involved in fad biosynthesis [catalytic activity 1: ATP + riboflavin = ADP + FMN] [catalytic activity 2: ATP + FMN = diphosphate + fad]; Belongs to the ribF family. (324 aa) |
| | thyA | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa) |
| | thyX | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa) |
| | pgsA3 | PGP synthase PgsA3; Involved in acidic phospholipid biosynthesis. this protein probably catalyzes the committed step to the synthesis of the acidic phospholipids [catalytic activity: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3- phosphatidyl)-glycerol 1-phosphate]; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa) |
| | suhB | Extragenic suppressor protein SuhB; In E. coli, SuhB mutation (SuhB2) enhances the synthesis of sigma(32) and suppresses temperature- sensitive growth of the RpoH15 mutant. may affect some step(S) of protein synthesis by facilitating the function of GroE or other heat shock proteins; Belongs to the inositol monophosphatase superfamily. (289 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | dxs1 | 1-deoxy-D-xylulose 5-phosphate synthase Dxs1; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa) |
| | pgsA1 | Pi synthase PgsA1; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. (234 aa) |
| | pimA | Alpha-mannosyltransferase PimA; Involved in the first mannosylation step in phosphatidylinositol mannoside biosynthesis (transfer of mannose residues onto pi, leading to the synthesis of phosphatidylinositol monomannoside). (374 aa) |
| | snzP | Pyridoxine biosynthesis protein, SnzP; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (282 aa) |
| | snoP | Glutamine amidotransferase SnoP; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (198 aa) |
| | apt | Adenine phosphoribosyltransferase, Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (184 aa) |
| | relA | GTP pyrophosphokinase RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (787 aa) |
| | pyrB | Aspartate carbamoyltransferase PyrB; Involved in pyrimidine biosynthesis (second step) [catalytic activity : carbamoyl phosphate + l-aspartate = phosphate + N-carbamoyl-L-aspartate]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | pyrC | Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa) |
| | MMAR_2197 | Secreted protein. (173 aa) |
| | carA | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. (375 aa) |
| | carB | Carbamoyl-phosphate synthase large chain CarB; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.]; Belongs to the CarB family. (1145 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase PyrF; Involved in the biosynthesis of pyrimidines [catalytic activity : orotidine 5'-phosphate = ump + CO(2)]; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa) |
| | gmk | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (197 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein, Dfp; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | MMAR_2234 | Conserved hypothetical protein. (267 aa) |
| | MMAR_2325 | Conserved hypothetical protein. (212 aa) |
| | plsB1 | Acyltransferase, PlsB1; Function unknown, but thought to be involved in lipid metabolism; Belongs to the GPAT/DAPAT family. (624 aa) |
| | nadA | Quinolinate synthetase NadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (352 aa) |
| | nadB | L-aspartate oxidase NadB; Catalyzes the oxidation of L-aspartate to iminoaspartate. (524 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphatase NadC; De novo biosynthesis of NAD and NADP [catalytic activity : nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D- ribose 1-diphosphate]; Belongs to the NadC/ModD family. (285 aa) |
| | impA | Inositol-monophosphatase ImpA; Involved in inositol phosphate metabolism. it is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. key enzyme of the phosphatidyl inositol signaling pathway [catalytic activity: inositol 1(or 4)-monophosphate + H(2)O = inositol + orthophosphate]. (270 aa) |
| | cya | Membrane-anchored adenylyl cyclase Cya; Involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (446 aa) |
| | coaE | dephospho-CoA kinase CoaE; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (408 aa) |
| | MMAR_2454 | Conserved hypothetical protein. (315 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase, PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (307 aa) |
| | MMAR_2502 | Conserved hypothetical membrane protein. (393 aa) |
| | pyrG | CTP synthase, PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (583 aa) |
| | MMAR_2508 | This is a family of myo-inositol-1-phosphate synthases. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction. (408 aa) |
| | cmk | Cytidylate kinase, Cmk; Catalyzes the transfer of a phosphate group from ATP to either CMP or ump to form CDP or UDP and ADP [catalytic activity: ATP + CMP = ADP + CDP]. (252 aa) |
| | MMAR_2550 | Conserved transmembrane protein. (431 aa) |
| | idsB | Polyprenyl synthetase IdsB; Involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of; Belongs to the FPP/GGPP synthase family. (328 aa) |
| | MMAR_2610 | Interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]. this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor. (481 aa) |
| | pgsA2 | CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase PgsA2; Thought to be involved in cardiolipin biosynthesis; generates cardiolipin from phosphatidylglycerol and CDP- diacylglycerol [catalytic activity : may be: phosphatidylglycerol + phosphatidylglycerol -> cardiolipin + glycerol, or: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate]; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (209 aa) |
| | guaB1 | Inosine-5'-monophosphate dehydrogenase GuaB1; Involved in GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'- phosphate + NADH]. (478 aa) |
| | cinA | Competence/damage-inducible protein CinA; CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation. (425 aa) |
| | MMAR_2826 | Conserved hypothetical membrane protein. (274 aa) |
| | MMAR_2875 | Aldehyde dehydrogenase; Thought to oxidize a wide variety of aliphatic and aromatic aldehydes. (507 aa) |
| | nadR | Predicted ATPase/kinase, NadR; Involved in NAD metabolism [coenzyme metabolism]. (340 aa) |
| | folE_1 | GTP cyclohydrolase I FolE_1; Involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)DiHYD ro pteridine triphosphate]. (242 aa) |
| | pncA | Pyrazinamidase/nicotinamidase, PncA; Converts amides such as nicotinamide to corresponding acid. (186 aa) |
| | MMAR_3042 | Conserved hypothetical protein; Function unknown. contains adenylate cyclase domain. (248 aa) |
| | MMAR_3043 | Adenylate cyclase. (1075 aa) |
| | pyrD | Dihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (360 aa) |
| | idsA2 | Geranylgeranyl pyrophosphate synthetase IdsA2; Involved in lipid biosynthesis; Belongs to the FPP/GGPP synthase family. (340 aa) |
| | idsB_2 | Polyprenyl synthetase IdsB_2; Involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; Belongs to the FPP/GGPP synthase family. (345 aa) |
| | pksG | Hydroxymethylglutaryl-coenzyme A synthase, PksG; Part of the mevalonate pathway for isoprenoid synthesis: conversion: acetyl-CoA + H(2)O + acetoacetyl- CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. (388 aa) |
| | MMAR_3216 | Diphosphomevalonate decarboxylase; Key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate + isopentenyl diphosphate + CO(2). (336 aa) |
| | idi | Isopentenyl-diphosphate delta-isomerase Idi; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (174 aa) |
| | idsB_1 | Polyprenyl synthetase IdsB_1; Involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; Belongs to the FPP/GGPP synthase family. (345 aa) |
| | MMAR_3225 | Conserved hypothetical integral membrane protein. (427 aa) |
| | MMAR_3226 | 1-acylglycerol-3-phosphate O-acyltransferase; Transfer of fatty acyl groups. (243 aa) |
| | MMAR_3257 | Adenylate cyclase. (381 aa) |
| | MMAR_3323 | Pyruvate dehydrogenase E1 component (alpha subunit); Involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]. (353 aa) |
| | MMAR_3345 | Conserved hypothetical protein. (320 aa) |
| | MMAR_3388 | Conserved hypothetical carboxylase. (492 aa) |
| | MMAR_3409 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (336 aa) |
| | MMAR_3426 | Conserved hypothetical membrane protein; Function unknown; contains putative acyltransferase domain. (272 aa) |
| | cdh | CDP-diacylglycerol pyrophosphatase Cdh; Involved in phospholipid biosynthesis [catalytic activity: CDP-diacylglycerol + H(2)O = CMP + phosphatidate]. (264 aa) |
| | acs_1 | Activates acetate to acetyl-coenzyme A [catalytic activity: ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA]. (599 aa) |
| | pdhA-2 | Pyruvate dehydrogenase E1 component (alpha subunit); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (334 aa) |
| | MMAR_3499 | Flavodoxin oxidoreductase; Function unknown; involved in electron transfer. (285 aa) |
| | MMAR_3556 | Oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; Belongs to the aldehyde dehydrogenase family. (496 aa) |
| | MMAR_3640 | Adenylate cyclase; Thought to play an essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'- cyclic AMP + pyrophosphate]. (642 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (215 aa) |
| | MMAR_3755 | Adenylate or guanylate cyclase; Generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp. (730 aa) |
| | MMAR_3757 | Adenylate or guanylate cyclase; Generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp. (719 aa) |
| | nadE | Glutamine-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (680 aa) |
| | ndkA | Nucleoside diphosphate kinase NdkA; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa) |
| | MMAR_3795 | Adenylate cyclase; Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]. (549 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein a MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (201 aa) |
| | plsB2 | Glycerol-3-phosphate acyltransferase PlsB2; Involved in phospholipid biosynthesis (at the first step). may also function in the regulation of membrane biogenesis [catalytic activity: acyl-CoA + SN-glycerol 3- phosphate = CoA + 1-acyl-SN-glycerol 3-phosphate]; Belongs to the GPAT/DAPAT family. (788 aa) |
| | plsC | Bifunctional transmembrane phospholipid biosynthesis enzyme PlsC; N-terminus: could be generate serine and phosphate from phosphoserine; may catalyze the last step in the biosynthesis of serine from carbohydrates (the reaction mechanism could be proceed via the formation of a phosphoryl-enzyme intermediates) [catalytic activity 1: phosphoserine + H(2)O = serine + phosphate]. mid-section: involved in phospholipid biosynthesis (at the second step); converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [catalytic activity 2: acyl-CoA + [...] (651 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component (alpha subunit) PdhA; Involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]. (363 aa) |
| | MMAR_3953 | Conserved hypothetical protein; Function unknown but domain identity suggests PlsC, phosphate acyltransferase. these enzymes function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2- acylglycerolphosphoethanolamine acyltransferase activities. (294 aa) |
| | MMAR_3965 | NAD-dependent aldehyde dehydrogenase; Thought to oxidize a wide variety of aliphatic and aromatic aldehydes; Belongs to the aldehyde dehydrogenase family. (496 aa) |
| | pncB | Nicotinic acid phosphoribosyltransferase PncB; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (438 aa) |
| | MMAR_4078 | Adenylate cyclase; Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]. (550 aa) |
| | MMAR_4079 | Adenylate cyclase; Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]. (534 aa) |
| | MMAR_4080 | Adenylate cyclase; Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]. (539 aa) |
| | atpC | ATP synthase epsilon chain AtpC; Produces ATP from ADP in the presence of a proton gradient across the membrane. (121 aa) |
| | atpD | ATP synthase beta chain AtpD; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (483 aa) |
| | atpG | ATP synthase gamma chain AtpG; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (304 aa) |
| | atpA | ATP synthase alpha chain AtpA; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (549 aa) |
| | atpH | ATP synthase delta chain AtpH; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (445 aa) |
| | atpF | ATP synthase B chain AtpF; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (170 aa) |
| | atpE | ATP synthase C chain AtpE; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpB | ATP synthase a chain AtpB; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (250 aa) |
| | MMAR_4120 | Adenylate cyclase; Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]. (527 aa) |
| | MMAR_4173 | Adenylate cyclase; Possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. (393 aa) |
| | fbiC | F420 biosynthesis protein FbiC; Essential for coenzyme F420 production: participates in a portion of the F420 biosynthetic pathway between pyrimidinedione and fo (biosynthesis intermediate), before the deazaflavin ring is formed. (856 aa) |
| | lpqW | Conserved lipoprotein LpqW. (635 aa) |
| | MMAR_4292 | Conserved transmembrane protein. (422 aa) |
| | MMAR_4340 | Conserved hypothetical protein. (274 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (332 aa) |
| | MMAR_4370 | Conserved hypothetical transmembrane protein. (502 aa) |
| | coaA | Pantothenate kinase CoaA; Coenzyme A (CoA) biosynthesis [catalytic activity : ATP + pantothenate = ADP + D-4'- phosphopantothenate.]. (312 aa) |
| | MMAR_4438 | Conserved hypothetical transmembrane protein. (510 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (492 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (307 aa) |
| | moeA1 | Molybdopterin biosynthesis protein MoeA1; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (429 aa) |
| | moaB2 | Pterin-4-alpha-carbinolamine dehydratase MoaB2; Thought to be involved in molybdopterin biosynthesis. catalyzes the dehydratation of 4A- hydroxytetrahydropterins [catalytic activity: (6R)-6-(L- erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro -4 A- hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)- 7,8-dihydro-6H-pterin + H(2)O.]. (181 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH; Involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide]. (523 aa) |
| | purN | 5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (219 aa) |
| | MMAR_4645 | Conserved protein. (152 aa) |
| | moaA2 | Molybdenum cofactor biosynthesis protein A2 MoaA2; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (360 aa) |
| | moaD2 | Involved in molybdenum cofactor biosynthesis. (89 aa) |
| | moaE2 | Possibly a molybdenum biosynthesis cofactor. conversion of molybdopterin precursor Z into molybdopterin requires transfer of two sulfur atoms to precursor Z (to generate the dithiolene group). this is catalyzed by the converting factor composed of a small and large subunit. (141 aa) |
| | mog | Involved in molybdopterin biosynthesis; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes. (161 aa) |
| | moaC2 | Molybdenum cofactor biosynthesis protein C 2 MoaC2; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (178 aa) |
| | MMAR_4784 | Dehydrogenase. (304 aa) |
| | purM | 5'-phosphoribosyl-5-aminoimidazole synthetase, PurM; Involved in de novo purine biosynthesis (at the fifth step) [catalytic activity: ATP + 5'- phosphoribosylformylglycinamidine = ADP + phosphate + 5'- phosphoribosyl-5-aminoimidazole]. (367 aa) |
| | purF | Amidophosphoribosyltransferase, PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II, PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to a [...] (765 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I, PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to as [...] (224 aa) |
| | purS | Conserved protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammon [...] (81 aa) |
| | purC | Phosphoribosylaminoimidazole- succinocarboxamide synthase, PurC; Involved in de novo purine biosynthesis (at the seventh step) [catalytic activity: ATP + 1-(5- phosphoribosyl)-4-carboxy-5-aminoimidazole + l-aspartate = ADP + phosphate + 1-(5-phosphoribosyl)-4-(N-succino- carboxamide)-5-aminoimidazole]; Belongs to the SAICAR synthetase family. (297 aa) |
| | purB | Adenylosuccinate lyase, PurB; Involved in de novo purine biosynthesis (at the eight step) catalytic activity: 1-(5-phosphoribosyl)-4-(N- succino-carboxamide) -5-aminoimidazole = fumarate + 5'- phosphoribosyl-5-amino-4-imidazolecarboxamide (also catalyzes: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa) |
| | purD | Phosphoribosylamine-glycine ligase, PurD; Involved in de novo purine biosynthesis (at the second step) [catalytic activity: ATP + 5- phosphoribosylamine + glycine = ADP + phosphate + 5'- phosphoribosylglycinamide]; Belongs to the GARS family. (422 aa) |
| | MMAR_5034 | Conserved hypothetical protein. (128 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (165 aa) |
| | ispD | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (227 aa) |
| | pyrE | Orotate phosphoribosyltransferase PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa) |
| | MMAR_0647 | Conserved secreted protein. (284 aa) |
| | dcd | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (190 aa) |
| | MMAR_0574 | Conserved hypothetical protein. (366 aa) |
| | MMAR_0569 | Conserved hypothetical transmembrane protein. (498 aa) |
| | MMAR_0472 | Aldehyde dehydrogenase; Thought to oxidize a wide variety of aliphatic and aromatic aldehydes; Belongs to the aldehyde dehydrogenase family. (488 aa) |
| | lipJ | Lignin peroxidase LipJ; Function unknown, probably involved in cellular metabolism. (458 aa) |
| | idsB_3 | Polyprenyl synthetase IdsB_3; Involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; Belongs to the FPP/GGPP synthase family. (329 aa) |
| | lytB2 | LytB-related protein LytB2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (333 aa) |
| | dxs2 | 1-deoxy-D-xylulose 5-phosphate synthase Dxs2; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (617 aa) |
| | gcpE_2 | GcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (387 aa) |
| | cyaA | Adenylate cyclase, CyaA; Possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. (374 aa) |
| | ino1 | Myo-inositol-1-phosphate synthase Ino1; Involved in phosphatidylinositol (pi) biosynthetic pathway [catalytic activity: d-glucose 6-phosphate = 1L- myo-inositol 1-phosphate]. (372 aa) |
| | MMAR_0053 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. (201 aa) |
| | thyA_1 | Thymidylate synthase, ThyA_1; Involved in deoxyribonucleotide biosynthesis. provides the sole de novo source of dTMP for dana biosynthesis [catalytic activity: 5,10- methylenetetrahydrofolate + dump = dihydrofolate + dTMP]. (316 aa) |
| | add | Adenosine deaminase Add; Catalyzes hydrolytic deamination of adenosine and generates inosine [catalytic activity: adenosine + H(2)O = inosine + NH(3) (also may act on deoxyadenosine)]; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (362 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa) |
| | guaA | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB3 | Inosine-5'-monophosphate (imp) dehydrogenase, GuaB3; Catalyses the first reaction unique to GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH]. (375 aa) |
| | guaB2 | Inosine-5'-monophosphate (imp) dehydrogenase, GuaB2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (532 aa) |
| | adk | Adenylate kinase (ATP-AMP transphosphorylase), Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa) |
| | MMAR_0935 | Adenylate cyclase. (274 aa) |
| | embR_2 | Transcriptional regulatory protein EmbR_2; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB. (276 aa) |
| | gpdA1 | Glycerol-3-phosphate dehydrogenase, GpdA1; Involved in de novo phospholipid biosynthesis; glycerol-3 phosphate formation [catalytic activity: SN- glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (341 aa) |
| | pimB | Mannosyltransferase, PimB; Involved in lipoarabinomannan (lam) biosynthesis. (383 aa) |
| | MMAR_0830 | Conserved protein. (355 aa) |
| | moeA2 | Molybdopterin biosynthesis protein MoeA2; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (401 aa) |
| | psd | Phosphatidylserine decarboxylase Psd; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (240 aa) |
| | pssA | CDP-diacylglycerol--serine o- phosphatidyltransferase PssA; Involved in phospholipid biosynthesis. generates phosphatidylserine [catalytic activity: CDP-diacylglycerol + L-serine = CMP + O-SN-phosphatidyl-L-serine]; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (272 aa) |
