STRINGSTRING
STY0076 STY0076 STY0077 STY0077 STY0353 STY0353 STY0718 STY0718 STY0886 STY0886 STY1000 STY1000 STY1159 STY1159 STY1272 STY1272 STY1536 STY1536 STY1815 STY1815 STY1820 STY1820 STY2561 STY2561 STY2592 STY2592 STY2834 STY2834 STY2911 STY2911 STY2912 STY2912 STY3259 STY3259 STY3470 STY3470 STY3510 STY3510 STY3511 STY3511 STY3750 STY3750 STY3874 STY3874 STY3901 STY3901 STY3917 STY3917 aspA aspA purA purA pyrI pyrI pyrB pyrB STY4866 STY4866
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0076Carbamoyl-phosphate synthase small chain; Orthologue of E. coli carA (CARA_ECOLI); Fasta hit to CARA_ECOLI (382 aa), 93% identity in 382 aa overlap; Belongs to the CarA family. (382 aa)
STY0077Carbamoyl-phosphate synthase large chain; Orthologue of E. coli carB (CARB_ECOLI); Fasta hit to CARB_ECOLI (1072 aa), 98% identity in 1072 aa overlap. (1075 aa)
STY0353Possible hydrolase; Similar to many hypothetical proteins e.g. Escherichia coli hypothetical protein in agr operon TR:Q9R2E1 (EMBL:D83536) (259 aa) fasta scores: E(): 0, 82.0% id in 255 aa, and to Bacillus subtilis YkrU protein ykrU TR:O31664 (EMBL:Z99111) (259 aa) fasta scores: E(): 4.3e-25, 32.7% id in 251 aa; Orthologue of E. coli YAFV_ECOLI; Fasta hit to YAFV_ECOLI (256 aa), 82% identity in 253 aa overlap. (255 aa)
STY0718Asparagine synthetase B; Orthologue of E. coli asnB (ASNB_ECOLI); Fasta hit to ASNB_ECOLI (553 aa), 95% identity in 553 aa overlap. (554 aa)
STY0886Similar to Escherichia coli putative L-asparaginase precursor ybiK SW:ASGX_ECOLI (P37595; P75795) (321 aa) fasta scores: E(): 0, 88.2% id in 313 aa, and to Arabidopsis thaliana L-asparaginase SW:ASPG_ARATH (P50287) (315 aa) fasta scores: E(): 0, 44.8% id in 299 aa, and to Lupinus luteus L-asparaginase SW:ASPG_LUPLU (Q9ZSD6) (325 aa) fasta scores: E(): 6.5e-16, 45.5% id in 308 aa; Orthologue of E. coli ybiK (ASGX_ECOLI); Fasta hit to ASGX_ECOLI (321 aa), 88% identity in 313 aa overlap. (313 aa)
STY1000Aspartate aminotransferase; Fasta hit to TYRB_ECOLI (397 aa), 43% identity in 397 aa overlap; Orthologue of E. coli aspC (AAT_ECOLI); Fasta hit to AAT_ECOLI (396 aa), 96% identity in 396 aa overlap; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
STY1159Proline dehydrogenase (proline oxidase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1320 aa)
STY1272Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
STY1536Similar to Escherichia coli aldehyde-dehydrogenase like protein YneI yneI SW:YNEI_ECOLI (P76149; P78220) (462 aa) fasta scores: E(): 0, 79.6% id in 353 aa, and to Escherichia coli aldehyde dehydrogenase A aldA SW:ALDA_ECOLI (P25553) (478 aa) fasta scores: E(): 0, 36.8% id in 348 aa. Contains C-terminal truncation. (375 aa)
STY1815NADP-specific glutamate dehydrogenase; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. (447 aa)
STY1820Orthologue of E. coli ansA (ASG1_ECOLI); Fasta hit to ASG1_ECOLI (338 aa), 94% identity in 338 aa overlap. (338 aa)
STY2561Putative aminotransferase; Similar to Methylobacillus flagellatum aspartate aminotransferase aat TR:Q9RAN0 (EMBL:L78665) (429 aa) fasta scores: E(): 0, 62.1% id in 404 aa and to many putative aminotransferases; Orthologue of E. coli YFBQ_ECOLI; Fasta hit to YFBQ_ECOLI (405 aa), 97% identity in 404 aa overlap. (404 aa)
STY2592Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
STY2834L-aspartate oxidase (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa)
STY2911Succinate-semialdehyde dehydrogenase; Fasta hit to ALDA_ECOLI (478 aa), 39% identity in 464 aa overlap; Fasta hit to FEAB_ECOLI (499 aa), 36% identity in 480 aa overlap; Fasta hit to YNEI_ECOLI (462 aa), 32% identity in 445 aa overlap; Fasta hit to ALDB_ECOLI (512 aa), 33% identity in 490 aa overlap; Fasta hit to DHAB_ECOLI (489 aa), 37% identity in 481 aa overlap; Fasta hit to DHAL_ECOLI (495 aa), 34% identity in 485 aa overlap; Fasta hit to ASTD_ECOLI (492 aa), 32% identity in 470 aa overlap; Fasta hit to YDCW_ECOLI (474 aa), 37% identity in 477 aa overlap; Orthologue of E. coli gabD [...] (482 aa)
STY29124-aminobutyrate aminotransferase; Fasta hit to GSA_ECOLI (426 aa), 32% identity in 421 aa overlap; Fasta hit to ARGM_ECOLI (406 aa), 34% identity in 404 aa overlap; Fasta hit to ARGD_ECOLI (405 aa), 36% identity in 411 aa overlap; Fasta hit to BIOA_ECOLI (429 aa), 32% identity in 353 aa overlap; Fasta hit to GOAG_ECOLI (421 aa), 53% identity in 421 aa overlap; Orthologue of E. coli gabT (GABT_ECOLI); Fasta hit to GABT_ECOLI (426 aa), 89% identity in 426 aa overlap; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
STY3259L-asparaginase; Highly similar to Escherichia coli L-asparaginase II precursor AnsB SW:ASG2_ECOLI (P00805) (348 aa) fasta scores: E(): 0, 92.8% id in 348 aa. Contains a possible N-terminal signal sequence; Belongs to the asparaginase 1 family. (348 aa)
STY3470Argininosuccinate synthetase; Orthologue of E. coli argG (ASSY_ECOLI); Fasta hit to ASSY_ECOLI (446 aa), 96% identity in 446 aa overlap; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (469 aa)
STY3510Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 0, 95.4% id in 1486 aa and to Pseudomonas aeruginosa glutamate synthase large subunit GltB TR:P95456 (EMBL:U81261) (1482 aa) fasta scores: E(): 0, 60.9% id in 1476 aa. (1486 aa)
STY3511Glutamate synthase (NADPH) small chain; Fasta hit to P76440 (412 aa), 33% identity in 443 aa overlap; Orthologue of E. coli gltD (GLTD_ECOLI); Fasta hit to GLTD_ECOLI (471 aa), 95% identity in 471 aa overlap. (472 aa)
STY3750Argininosuccinate lyase; Orthologue of E. coli argH (ARLY_ECOLI); Fasta hit to ARLY_ECOLI (457 aa), 95% identity in 456 aa overlap. (458 aa)
STY3874Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
STY3901Asparagine synthetase A; Orthologue of E. coli asnA (ASNA_ECOLI); Fasta hit to ASNA_ECOLI (330 aa), 95% identity in 330 aa overlap; Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily. (330 aa)
STY3917Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
aspASimilar to Escherichia coli Aspartate ammonia-lyase aspA SW:ASPA_ECOLI (P04422) (478 aa) fasta scores: E(): 0, 97.1% id in 478 aa, and to Serratia marcescens Aspartate ammonia-lyase aspA SW:ASPA_SERMA (P33109) (478 aa) fasta scores: E(): 0, 89.7% id in 478 aa. (478 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
pyrBSimilar to Salmonella typhimurium aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_SALTY (P08420) (309 aa) fasta scores: E(): 0, 98.4% id in 310 aa, and to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 95.2% id in 310 aa; Fasta hit to OTC2_ECOLI (333 aa), 32% identity in 298 aa overlap; Fasta hit to OTC1_ECOLI (333 aa), 32% identity in 295 aa overlap. (311 aa)
STY4866Similar to Desulfurococcus sp aspartate racemase TR:P71164 (EMBL:D84067) (235 aa) fasta scores: E(): 1.2e-25, 34.9% id in 235 aa, and to Thermococcus sp aspartate racemase TR:O93779 (EMBL:AB015880) (232 aa) fasta scores: E(): 8.4e-26, 36.4% id in 225 aa; Belongs to the aspartate/glutamate racemases family. (244 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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