STRINGSTRING
STY0254 STY0254 STY0285 STY0285 STY0528 STY0528 STY0530 STY0530 STY0697 STY0697 STY1240 STY1240 STY2082 STY2082 STY2102 STY2102 ruvA ruvA STY2106 STY2106 STY2825 STY2825 STY2950 STY2950 recD recD recB recB recC recC STY3198 STY3198 STY3775 STY3775 STY3881 STY3881 STY3941 STY3941 STY3942 STY3942 STY4048 STY4048 ssb ssb ssB ssB priB priB holC holC dnaT dnaT holD holD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0254DNA polymerase III, alpha chain; Orthologue of E. coli dnaE (DP3A_ECOLI); Fasta hit to DP3A_ECOLI (1160 aa), 97% identity in 1160 aa overlap. (1160 aa)
STY0285DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'- 5' exonuclease (By similarity). (243 aa)
STY0528DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (642 aa)
STY0530Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
STY0697DNA polymerase III, delta subunit; Orthologue of E. coli holA (HOLA_ECOLI); Fasta hit to HOLA_ECOLI (343 aa), 90% identity in 343 aa overlap. (343 aa)
STY1240DNA polymerase III, delta' subunit; Orthologue of E. coli holB (HOLB_ECOLI); Fasta hit to HOLB_ECOLI (334 aa), 79% identity in 334 aa overlap. (334 aa)
STY2082DNA polymerase III, theta subunit; Orthologue of E. coli holE (HOLE_ECOLI); Fasta hit to HOLE_ECOLI (76 aa), 88% identity in 76 aa overlap. (76 aa)
STY2102Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa)
ruvAHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
STY2106Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (173 aa)
STY2825DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. Belongs to the RecO family. (242 aa)
STY2950RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
recDExonuclease V alpha-subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Hol [...] (611 aa)
recBExonuclease V subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzym [...] (1181 aa)
recCExonuclease V subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzym [...] (1123 aa)
STY3198Single-stranded DNA-specific exonuclease; Orthologue of E. coli recJ (RECJ_ECOLI); Fasta hit to RECJ_ECOLI (577 aa), 91% identity in 577 aa overlap. (577 aa)
STY3775Primosomal protein replication factor; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa)
STY3881DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (928 aa)
STY3941DNA polymerase III beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
STY3942recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). (357 aa)
STY4048ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa)
ssbSingle-strand DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (176 aa)
ssBPreviously sequenced Salmonella typhi single strand binding protein ssB TR:Q9RHF4 (EMBL:AF000001) (178 aa) fasta scores: E(): 0, 100.0% id in 178 aa. Also highly similar to other single-stranded DNA-binding proteins including: Escherichia coli SW:SSB_ECOLI () (177 aa) fasta scores: E(): 0, 71.8% id in 177 aa and Bacteriophage P1 single-stranded DNA-binding protein Ssb-p1 ssb-p1 TR:Q9XJG4 (EMBL:AF125376) (162 aa) fasta scores: E(): 0, 67.7% id in 164 aa. (178 aa)
priBPrimosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT; Belongs to the PriB family. (104 aa)
holCSimilar to Escherichia coli DNA polymerase III, chi subunit HolC SW:HOLC_ECOLI (P28905) (147 aa) fasta scores: E(): 0, 95.2% id in 147 aa and to Haemophilus influenzae DNA polymerase III, chi subunit HolC SW:HOLC_HAEIN (P43749) (144 aa) fasta scores: E(): 1.4e-26, 48.6% id in 142 aa. (160 aa)
dnaTPrimosomal protein I; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'. (179 aa)
holDDNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (145 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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