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rpsE rpsE yabR yabR rpsL rpsL rpsG rpsG rpsJ rpsJ rpsS rpsS rpsC rpsC rpsQ rpsQ rpsNA rpsNA rpsH rpsH rpsM rpsM rpsK rpsK rpsI rpsI rpsNB rpsNB rpsP rpsP rpsB rpsB rpsO rpsO rpfA rpfA rpsT rpsT rpsD rpsD hpf hpf rpsR rpsR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations); Belongs to the universal ribosomal protein uS5 family. (166 aa)
yabRPutative RNA degradation protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the peptidase U57 family. (128 aa)
rpsLRibosomal protein S12 (BS12); With S4 and S5 plays an important role in translational accuracy. (138 aa)
rpsGRibosomal protein S7 (BS7); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJRibosomal protein S10 (BS13); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsSRibosomal protein S19 (BS19); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rpsCRibosomal protein S3 (BS3); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rpsQRibosomal protein S17 (BS16); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (87 aa)
rpsNARibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity). The major S14 protein in the ribosome. Required for binding of S2 and S3 to the 30S subunit and for association of the 30S with the 50S subunit; Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily. (61 aa)
rpsHRibosomal protein S8 (BS8); One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsMRibosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpsKRibosomal protein S11 (BS11); Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpsIRibosomal protein S9; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type s: structure. (130 aa)
rpsNBAlternative ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (89 aa)
rpsPRibosomal protein S16 (BS17); Evidence 1a: Function experimentally demonstrated in the studied strain; Product type f: factor. (90 aa)
rpsBRibosomal protein S2; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; structure. (246 aa)
rpsORibosomal protein S15 (BS18); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
rpfARNA degradation presenting factor (ribosomal protein S1 homolog); Plays a role in sporulation; Belongs to the bacterial ribosomal protein bS1 family. (382 aa)
rpsTRibosomal protein S20 (BS20); Binds directly to 16S ribosomal RNA; Belongs to the bacterial ribosomal protein bS20 family. (88 aa)
rpsDRibosomal protein S4 (BS4); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. S4 represses its own expression; it is not know if this is at the level of translation or of mRNA stability; Belongs to the universal ribosomal protein uS4 family. (200 aa)
hpfRibosome-associated sigma 54 modulation protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. May not be the only factor implicated. Might negatively regulate the activity of the sigma-54 factor (SigL). (189 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. (79 aa)
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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