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eif2g eif2g rpoE2 rpoE2 Abm4_0744 Abm4_0744 Abm4_0793 Abm4_0793 Abm4_0818 Abm4_0818 Abm4_0835 Abm4_0835 Abm4_0838 Abm4_0838 Abm4_0850 Abm4_0850 Abm4_0891 Abm4_0891 Abm4_0908 Abm4_0908 Abm4_0977 Abm4_0977 nikR nikR tfs1 tfs1 Abm4_1072 Abm4_1072 Abm4_1102 Abm4_1102 Abm4_1116 Abm4_1116 Abm4_1138 Abm4_1138 Abm4_1159 Abm4_1159 Abm4_1172 Abm4_1172 Abm4_1187 Abm4_1187 Abm4_1191 Abm4_1191 Abm4_1225 Abm4_1225 Abm4_1269 Abm4_1269 birA birA dphB dphB eif2b eif2b phoU2 phoU2 Abm4_1467 Abm4_1467 eif1a eif1a Abm4_1615 Abm4_1615 Abm4_1638 Abm4_1638 eif2a eif2a tfs2 tfs2 Abm4_1653 Abm4_1653 Abm4_1678 Abm4_1678 ef1b ef1b Abm4_0053 Abm4_0053 Abm4_0072 Abm4_0072 fwdH fwdH Abm4_0151 Abm4_0151 tbp tbp eif6 eif6 pelA pelA Abm4_0250 Abm4_0250 tfe tfe spt5 spt5 rpl1 rpl1 fusA fusA tuf tuf Abm4_0387 Abm4_0387 Abm4_0412 Abm4_0412 ahaH ahaH Abm4_0437 Abm4_0437 tfb tfb prf1 prf1 eif5a eif5a Abm4_0515 Abm4_0515 Abm4_0567 Abm4_0567 Abm4_0582 Abm4_0582 Abm4_0648 Abm4_0648 Abm4_0703 Abm4_0703 infB infB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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eif2gTranslation initiation factor aIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa)
rpoE2DNA-directed RNA polymerase subunit E'' RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (62 aa)
Abm4_0744Transcriptional regulator/CBS domain-containing protein. (300 aa)
Abm4_0793Hypothetical protein. (198 aa)
Abm4_0818ATP-binding protein. (227 aa)
Abm4_0835Transcriptional regulator HxlR family. (133 aa)
Abm4_0838Transcriptional regulator MarR family. (130 aa)
Abm4_0850Transcriptional regulator TetR family. (196 aa)
Abm4_0891Transcriptional regulator ArsR family. (114 aa)
Abm4_0908Iron-dependent repressor. (213 aa)
Abm4_0977HTH domain-containing protein. (163 aa)
nikRNickel responsive transcriptional regulator NikR; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (147 aa)
tfs1Transcription factor S Tfs1; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (106 aa)
Abm4_1072Transcriptional regulator TetR family. (208 aa)
Abm4_1102Transcriptional regulator TetR family. (192 aa)
Abm4_1116Transcriptional regulator MarR family. (151 aa)
Abm4_1138Transcriptional regulator MarR family. (270 aa)
Abm4_1159Transcriptional regulator TetR family. (202 aa)
Abm4_1172Transcriptional regulator ArsR family. (105 aa)
Abm4_1187Transcriptional regulator TetR family. (189 aa)
Abm4_1191HTH domain-containing protein. (125 aa)
Abm4_1225Transcriptional regulator MarR family. (147 aa)
Abm4_1269Translation initiation factor aSUI1; Belongs to the SUI1 family. (115 aa)
birAbiotin-acetyl-CoA-carboxylase ligase BirA. (303 aa)
dphBDiphthine synthase DphB; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (264 aa)
eif2bTranslation initiation factor aIF-2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (137 aa)
phoU2Phosphate uptake regulator PhoU2. (296 aa)
Abm4_1467Transcriptional regulator. (151 aa)
eif1aTranslation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (104 aa)
Abm4_1615Transcriptional regulator ArsR family. (181 aa)
Abm4_1638Transcriptional regulator ArsR family. (114 aa)
eif2aTranslation initiation factor aIF-2 alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (265 aa)
tfs2Transcription factor S Tfs2; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa)
Abm4_1653Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (336 aa)
Abm4_1678Transcriptional regulator ArsR family. (273 aa)
ef1bTranslation elongation factor aEF-1 beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa)
Abm4_0053Transcriptional regulator MarR family. (157 aa)
Abm4_0072HTH domain-containing protein. (65 aa)
fwdHTungsten formylmethanofuran dehydrogenase subunit H FwdH. (155 aa)
Abm4_0151Transcriptional regulator LysR family. (291 aa)
tbpTATA-box binding protein Tbp; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (181 aa)
eif6Translation initiation factor aIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (224 aa)
pelACell division protein pelota PelA; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (353 aa)
Abm4_0250HD domain-containing protein. (164 aa)
tfeTranscription initiation factor TFIIE alpha subunit Tfe; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabili [...] (151 aa)
spt5Ribosomal protein L24 family; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (160 aa)
rpl1Ribosomal protein L1P Rpl1p; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
fusATranslation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (730 aa)
tufTranslation elongation factor aEF-1 alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (413 aa)
Abm4_0387Hypothetical protein. (246 aa)
Abm4_0412HTH domain-containing protein. (312 aa)
ahaHA1A0 archaeal ATP synthase subunit H AhaH. (104 aa)
Abm4_0437Transcriptional regulator ArsR family. (112 aa)
tfbTranscription initiation factor TFIIB Tfb; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (310 aa)
prf1Peptide chain release factor aRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (411 aa)
eif5aTranslation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (135 aa)
Abm4_0515Hypothetical protein. (211 aa)
Abm4_0567Transcriptional regulator TetR family. (187 aa)
Abm4_0582Transcriptional regulator MarR family. (151 aa)
Abm4_0648Transcriptional regulator TetR family. (199 aa)
Abm4_0703Iron-dependent repressor. (241 aa)
infBTranslation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (595 aa)
Your Current Organism:
Methanobrevibacter sp. AbM4
NCBI taxonomy Id: 224719
Other names: M. sp. AbM4
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