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| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (288 aa) |
| | hcgA | BioB family protein HcgA. (333 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase RibB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (212 aa) |
| | ribK | Riboflavin kinase RibK; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (126 aa) |
| | Abm4_0018 | Cobyrinic acid a,c-diamide synthase-related protein. (507 aa) |
| | leuA | 2-isopropylmalate synthase LeuA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (514 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (468 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | ilvD | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (551 aa) |
| | argF | Ornithine carbamoyltransferase ArgF; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (302 aa) |
| | ilvB1 | Acetolactate synthase large subunit IlvB1. (566 aa) |
| | cbiB | Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (369 aa) |
| | cbiG | Cobalamin biosynthesis protein CbiG. (344 aa) |
| | cbiH | precorrin-3B C17-methyltransferase CbiH. (356 aa) |
| | thiL | Thiamine monphosphate kinase ThiL; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (344 aa) |
| | Abm4_1723 | UbiD family decarboxylase. (428 aa) |
| | ribH | 6,7-dimethyl-8- ribityllumazine synthase RibH; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (141 aa) |
| | Abm4_1713 | Nucleotide sugar dehydrogenase. (442 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | leuB | 3-isopropylmalate dehydrogenase LeuB. (329 aa) |
| | Abm4_1699 | CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (373 aa) |
| | glyA | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa) |
| | afpA | Archaeoflavoprotein AfpA. (235 aa) |
| | cbiL | Precorrin-2 C20-methyltransferase CbiL; Belongs to the precorrin methyltransferase family. (231 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (281 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (286 aa) |
| | apt | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (191 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase HisE. (96 aa) |
| | Abm4_1608 | Radical SAM domain-containing protein. (333 aa) |
| | argG | Argininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (391 aa) |
| | Abm4_1570 | 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (171 aa) |
| | queE | Radical SAM domain-containing protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (233 aa) |
| | pheA | Prephenate dehydratase PheA. (234 aa) |
| | comC | L-sulfolactate dehydrogenase ComC. (342 aa) |
| | cofG | FO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (379 aa) |
| | comB | 2-phosphosulfolactate phosphatase ComB. (232 aa) |
| | cobY | GTP:adenosylcobinamide-phosphate guanylyltransferase CobY. (206 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase Gap. (337 aa) |
| | thi4 | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (262 aa) |
| | Abm4_1455 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (244 aa) |
| | trpE | Anthranilate synthase component I TrpE. (415 aa) |
| | trpG | Anthranilate synthase component II TrpG. (188 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase TrpC. (265 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Belongs to the TrpF family. (222 aa) |
| | trpB | Tryptophan synthase subunit beta TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase alpha subunit TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (355 aa) |
| | Abm4_1381 | Hypothetical protein. (220 aa) |
| | nadA | Quinolinate synthetase A protein NadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | Abm4_1357 | Pyridoxamine 5'-phosphate oxidase family protein. (130 aa) |
| | Abm4_1317 | Translation initiation factor aIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (309 aa) |
| | pycA | Pyruvate carboxylase subunit A PycA. (495 aa) |
| | dapL | Diaminopimelate aminotransferase DapL; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa) |
| | thiD | Phosphomethylpyrimidine kinase ThiD. (247 aa) |
| | Abm4_1201 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (241 aa) |
| | Abm4_1200 | Adhesin-like protein. (600 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (454 aa) |
| | cysKM | Cysteine synthase CysKM. (329 aa) |
| | cysE | Serine O-acetyltransferase CysE. (227 aa) |
| | Abm4_1185 | O-acetylhomoserine/O-acetylserine sulfhydrylase. (451 aa) |
| | Abm4_1182 | Metallo-beta-lactamase superfamily protein. (283 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa) |
| | Abm4_1166 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (216 aa) |
| | Abm4_1149 | Hydrolase HAD superfamily. (231 aa) |
| | hemD | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (261 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Belongs to the SAICAR synthetase family. (246 aa) |
| | serS | seryl-tRNA synthetase SerS. (425 aa) |
| | Abm4_1087 | Hexapeptide repeat-containing acetyltransferase. (190 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (418 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | aksF | Isohomocitrate dehydrogenase AksF. (337 aa) |
| | pdxT | Pyridoxine biosynthesis glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | gltA | Glutamate synthase alpha subunit GltA; Belongs to the glutamate synthase family. (497 aa) |
| | Abm4_0989 | SAM-dependent methyltransferase. (274 aa) |
| | Abm4_0983 | D-alanine-D-alanine ligase. (376 aa) |
| | cimA | Citramalate synthase CimA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa) |
| | hisAF | hisA/hisF family protein HisAF; Belongs to the HisA/HisF family. (228 aa) |
| | pdxS | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa) |
| | Abm4_0901 | Thioesterase. (135 aa) |
| | aroD | 3-dehydroquinate dehydratase type I AroD; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (230 aa) |
| | panE | 2-dehydropantoate 2-reductase PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (315 aa) |
| | Abm4_0812 | Hexapeptide repeat-containing acetyltransferase. (213 aa) |
| | Abm4_0811 | Hexapeptide repeat-containing acetyltransferase. (212 aa) |
| | hom | Homoserine dehydrogenase Hom. (340 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolyzing) AsnB. (516 aa) |
| | Abm4_0804 | O-acetylhomoserine/O-acetylserine sulfhydrylase. (429 aa) |
| | metX1 | Homoserine O-acetyltransferase MetX1; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (490 aa) |
| | arfB | Creatinine amidohydrolase ArfB; Catalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy). (230 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa) |
| | hisS | histidyl-tRNA synthetase HisS; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | aroE | Shikimate 5-dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (293 aa) |
| | cofH | FO synthase subunit 2 CofH; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (374 aa) |
| | cbiT | precorrin-6Y C5,15- methyltransferase (decarboxylating) CbiT; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (188 aa) |
| | ribC | Riboflavin synthase RibC. (152 aa) |
| | cbiN2 | Cobalt transport protein CbiN2; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (97 aa) |
| | cbiM2 | Cobalamin biosynthesis protein CbiM2; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (226 aa) |
| | Abm4_0726 | Hexapeptide repeat-containing acetyltransferase. (205 aa) |
| | argH | Argininosuccinate lyase ArgH. (469 aa) |
| | thrC | Threonine synthase ThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (401 aa) |
| | comD | Sulfopyruvate decarboxylase alpha subunit ComD. (168 aa) |
| | comE | Sulfopyruvate decarboxylase beta subunit ComE. (178 aa) |
| | Abm4_0692 | Methanogenesis marker protein 16. (426 aa) |
| | comA | Phosphosulfolactate synthase ComA. (257 aa) |
| | proC | Pyrroline-5-carboxylate reductase ProC. (271 aa) |
| | cpgS | Cyclic 2,3-diphosphoglycerate synthetase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (456 aa) |
| | cbiC | precorrin-8X methylmutase CbiC. (213 aa) |
| | hisD | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase UppS; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (254 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine reductase RibD. (219 aa) |
| | aroA-2 | Phospho-2-dehydro-3-deoxyheptonate aldolase/fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (378 aa) |
| | cbiX2 | Cobalamin biosynthesis protein CbiX2. (307 aa) |
| | cbiX1 | Cobalamin biosynthesis protein CbiX1; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (152 aa) |
| | cbiF | Precorrin-4 C11-methyltransferase CbiF. (251 aa) |
| | Abm4_0612 | Hypothetical protein. (136 aa) |
| | metE | Methionine synthase MetE. (321 aa) |
| | cbiP | Cobyric acid synthase CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (525 aa) |
| | Abm4_0588 | Pyridoxamine 5'-phosphate oxidase family protein. (134 aa) |
| | Abm4_0585 | Hypothetical protein. (221 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | dapA | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | ask | Aspartate kinase Ask; Belongs to the aspartokinase family. (408 aa) |
| | aroK | Shikimate kinase AroK. (286 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (382 aa) |
| | aksE | Homoaconitase small subunit AksE; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD [...] (161 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA. (246 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | Abm4_0466 | Pyridoxal/pyridoxine/pyridoxamine kinase. (282 aa) |
| | Abm4_0435 | Hypothetical protein. (134 aa) |
| | Abm4_0434 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (267 aa) |
| | serA | Phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa) |
| | carB | Carbamoylphosphate synthase large subunit CarB; Belongs to the CarB family. (1065 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit CarA; Belongs to the CarA family. (369 aa) |
| | cbiJ | Precorrin-6x reductase CbiJ. (273 aa) |
| | thiM | Hydroxyethylthiazole kinase ThiM; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (291 aa) |
| | thiE | Thiamine monophosphate synthase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (208 aa) |
| | tpiA | Triosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa) |
| | cobS | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (288 aa) |
| | queC | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (226 aa) |
| | Abm4_0312 | Hexapeptide repeat-containing acetyltransferase. (210 aa) |
| | pycB | Pyruvate carboxylase subunit B PycB. (569 aa) |
| | Abm4_0310 | Myo-inositol-1-phosphate synthase. (368 aa) |
| | Abm4_0301 | Hexapeptide repeat-containing acetyltransferase. (166 aa) |
| | fbp | Fructose 1,6-bisphosphatase Fbp; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | thiI | Thiamine biosynthesis ATP pyrophosphatase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (382 aa) |
| | tyrA | Prephenate dehydrogenase TyrA. (435 aa) |
| | thiC2 | Thiamine biosynthesis protein ThiC2; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa) |
| | hisC | Histidinol-phosphate aminotransferase HisC. (365 aa) |
| | mtnP | Methylthioadenosine phosphorylase MtnP; Purine nucleoside phosphorylase involved in purine salvage. (251 aa) |
| | mptE | Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (242 aa) |
| | Abm4_0211 | Aminotransferase class V family. (381 aa) |
| | serB | Phosphoserine phosphatase SerB. (499 aa) |
| | aksD | Homoaconitase large subunit AksD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa) |
| | Abm4_0179 | Chorismate lyase. (189 aa) |
| | glnA | Glutamine synthetase GlnA. (446 aa) |
| | thiC1 | Thiamine biosynthesis protein ThiC1; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (434 aa) |
| | Abm4_0123 | Hydrogenase expression/formation related protein. (457 aa) |
| | hisH | Imidazole glycerol phosphate synthase glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa) |
| | cbiE | Precorrin-6y C5,15-methyltransferase (decarboxylating) CbiE. (213 aa) |
| | cobT | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase CobT; Belongs to the UPF0284 family. (353 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | ilvN | Acetolactate synthase small subunit IlvN. (161 aa) |
