| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HP15_2053 | HP15_2655 | HP15_2053 | HP15_2655 | PrpE protein. | Methylmalonate-semialdehyde dehydrogenase. | 0.937 |
| HP15_2053 | HP15_3945 | HP15_2053 | HP15_3945 | PrpE protein. | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | 0.875 |
| HP15_2053 | acsA | HP15_2053 | HP15_811 | PrpE protein. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.910 |
| HP15_2053 | aldH6A1 | HP15_2053 | HP15_906 | PrpE protein. | Methylmalonate-semialdehyde dehydrogenase. | 0.937 |
| HP15_2655 | HP15_2053 | HP15_2655 | HP15_2053 | Methylmalonate-semialdehyde dehydrogenase. | PrpE protein. | 0.937 |
| HP15_2655 | HP15_3945 | HP15_2655 | HP15_3945 | Methylmalonate-semialdehyde dehydrogenase. | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | 0.920 |
| HP15_2655 | acsA | HP15_2655 | HP15_811 | Methylmalonate-semialdehyde dehydrogenase. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.937 |
| HP15_2655 | aldH6A1 | HP15_2655 | HP15_906 | Methylmalonate-semialdehyde dehydrogenase. | Methylmalonate-semialdehyde dehydrogenase. | 0.905 |
| HP15_3945 | HP15_2053 | HP15_3945 | HP15_2053 | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | PrpE protein. | 0.875 |
| HP15_3945 | HP15_2655 | HP15_3945 | HP15_2655 | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | Methylmalonate-semialdehyde dehydrogenase. | 0.920 |
| HP15_3945 | acsA | HP15_3945 | HP15_811 | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.937 |
| HP15_3945 | aldH6A1 | HP15_3945 | HP15_906 | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | Methylmalonate-semialdehyde dehydrogenase. | 0.922 |
| acsA | HP15_2053 | HP15_811 | HP15_2053 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | PrpE protein. | 0.910 |
| acsA | HP15_2655 | HP15_811 | HP15_2655 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Methylmalonate-semialdehyde dehydrogenase. | 0.937 |
| acsA | HP15_3945 | HP15_811 | HP15_3945 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | 0.937 |
| acsA | aldH6A1 | HP15_811 | HP15_906 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Methylmalonate-semialdehyde dehydrogenase. | 0.937 |
| aldH6A1 | HP15_2053 | HP15_906 | HP15_2053 | Methylmalonate-semialdehyde dehydrogenase. | PrpE protein. | 0.937 |
| aldH6A1 | HP15_2655 | HP15_906 | HP15_2655 | Methylmalonate-semialdehyde dehydrogenase. | Methylmalonate-semialdehyde dehydrogenase. | 0.905 |
| aldH6A1 | HP15_3945 | HP15_906 | HP15_3945 | Methylmalonate-semialdehyde dehydrogenase. | Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. | 0.922 |
| aldH6A1 | acsA | HP15_906 | HP15_811 | Methylmalonate-semialdehyde dehydrogenase. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.937 |