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aroE aroE HNE_0037 HNE_0037 asd asd hisE hisE hisF hisF hisA hisA hisH hisH hisB hisB aroK aroK aroB aroB HNE_0095 HNE_0095 aroA aroA argB argB dapD dapD dapB dapB pgsA pgsA hisS hisS HNE_0578 HNE_0578 hisG hisG argD argD argF argF HNE_0613 HNE_0613 HNE_0618 HNE_0618 HNE_0652 HNE_0652 HNE_0659 HNE_0659 tnaA tnaA aroC aroC hisC hisC hisD hisD phhA phhA HNE_1580 HNE_1580 HNE_1643 HNE_1643 trpC trpC trpD trpD trpG trpG trpE trpE HNE_1791 HNE_1791 aroQ aroQ argC argC HNE_2357 HNE_2357 pabA pabA pabB pabB dadA dadA dapA dapA hppD hppD aatA aatA HNE_3096 HNE_3096 HNE_3117 HNE_3117 argJ argJ hisI hisI HNE_3400 HNE_3400 lysA lysA argH argH trpA trpA cutA cutA trpB trpB trpF trpF argG argG dapF dapF
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (270 aa)
HNE_0037Chorismate mutase; Identified by match to protein family HMM PF01817; match to protein family HMM TIGR01795. (103 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
hisEphosphoribosyl-ATP diphosphatase; Identified by similarity to SP:P50935; match to protein family HMM PF01503; Belongs to the PRA-PH family. (120 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. (241 aa)
hisHImidazoleglycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa)
hisBImidazoleglycerol phosphate dehydratase; Identified by match to protein family HMM PF00475. (208 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (373 aa)
HNE_0095Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01409. (387 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (439 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (297 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Identified by match to protein family HMM TIGR00965; Belongs to the transferase hexapeptide repeat family. (275 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (276 aa)
pgsACDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identified by match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (217 aa)
hisShistidyl-tRNA synthetase; Identified by match to protein family HMM PF00587; match to protein family HMM PF03129; match to protein family HMM TIGR00442. (497 aa)
HNE_0578tRNA synthetase class II core domain protein; Identified by match to protein family HMM PF00587. (373 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (236 aa)
argDAcetylornithine/succinylornithine aminotransferase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (308 aa)
HNE_0613Decarboxylase, group II; Identified by match to protein family HMM PF00282. (494 aa)
HNE_0618Asparate kinase, monofunctional class; Identified by similarity to SP:P41403; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (415 aa)
HNE_0652Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. (396 aa)
HNE_0659Prephenate dehydratase; Identified by match to protein family HMM PF00800. (278 aa)
tnaAIdentified by match to protein family HMM PF01212; Belongs to the beta-eliminating lyase family. (454 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
hisCHistidinol-phosphate aminotransferase; Identified by similarity to SP:P17731; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
phhAPhenylalanine-4-hydroxylase; Identified by similarity to SP:P30967; match to protein family HMM PF00351; match to protein family HMM TIGR01267. (293 aa)
HNE_1580HAD hydrolase, IB family; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. (226 aa)
HNE_1643Aspartate kinase; Identified by match to protein family HMM PF00696; match to protein family HMM PF01842. (482 aa)
trpCIndole-3-glycerol phosphate synthase; Identified by similarity to SP:P20577; match to protein family HMM PF00218; Belongs to the TrpC family. (265 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa)
trpGAnthranilate synthase component II; Identified by similarity to GB:BAC65123.1; match to protein family HMM PF00117; match to protein family HMM TIGR00566. (190 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa)
HNE_1791Peptidylprolyl cis-trans isomerase, homolog; Identified by similarity to SP:P77241. (637 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (311 aa)
HNE_2357Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. (384 aa)
pabA4-amino-4-deoxychorismate synthase, glutamine amidotransferase subunit; Identified by similarity to SP:P28819; match to protein family HMM PF00117; match to protein family HMM TIGR00566. (194 aa)
pabB4-amino-4-deoxychorismate synthase, aminodeoxychorismate synthase subunit; Identified by similarity to SP:P05041; match to protein family HMM PF00425; match to protein family HMM PF04715. (452 aa)
dadAD-amino acid dehydrogenase, small subunit; Identified by similarity to SP:P29011; match to protein family HMM PF01266. (410 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
hppD4-hydroxyphenylpyruvate dioxygenase; Identified by similarity to SP:P80064; match to protein family HMM PF00903; match to protein family HMM TIGR01263. (366 aa)
aatAAspartate aminotransferase; Identified by similarity to SP:Q02635; match to protein family HMM PF00155. (403 aa)
HNE_3096Putative pterin-4a-carbinolamine dehydratase; Identified by match to protein family HMM PF01329. (96 aa)
HNE_3117Putative D-alanine aminotransferase; Identified by match to protein family HMM PF01063. (296 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (416 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (131 aa)
HNE_3400Prephenate dehydrogenase; Identified by match to protein family HMM PF01408; match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. (313 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (424 aa)
argHArgininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (465 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (275 aa)
cutADivalent-cation tolerance protein CutA; Identified by similarity to SP:P36654; match to protein family HMM PF03091. (106 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa)
trpFN-(5'phosphoribosyl)anthranilate isomerase; Identified by match to protein family HMM PF00697; Belongs to the TrpF family. (211 aa)
argGArgininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (269 aa)
Your Current Organism:
Hyphomonas neptunium
NCBI taxonomy Id: 228405
Other names: H. neptunium ATCC 15444, Hyphomonas neptunium ATCC 15444, Hyphomonas neptunium str. ATCC 15444, Hyphomonas neptunium strain ATCC 15444
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