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| | purD | KEGG: pol:Bpro_1969 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (428 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa) |
| | atpA | ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (519 aa) |
| | atpH | ATP synthase F1 subcomplex delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (287 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (326 aa) |
| | Ajs_0268 | PFAM: conserved hypothetical protein 701; KEGG: rfr:Rfer_3804 conserved hypothetical protein 701. (142 aa) |
| | Ajs_0266 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pol:Bpro_0245 porphobilinogen synthase; Belongs to the ALAD family. (335 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (236 aa) |
| | Ajs_0219 | PFAM: protein of unknown function DUF336; KEGG: reu:Reut_B5688 protein of unknown function DUF336. (143 aa) |
| | Ajs_0165 | Gluconolactonase; PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: rfr:Rfer_0479 senescence marker protein-30 (SMP-30). (316 aa) |
| | Ajs_0054 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: pol:Bpro_0120 acetoacetyl-CoA synthase. (754 aa) |
| | Ajs_0043 | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: pol:Bpro_0113 ATP--cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | Ajs_0037 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: dar:Daro_0521 sigma-70 region 2:sigma-70 region 4; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | Ajs_1830 | KEGG: rfr:Rfer_2040 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP C-terminal domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1187 aa) |
| | Ajs_1787 | TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mfa:Mfla_0997 phosphomethylpyrimidine kinase. (308 aa) |
| | Ajs_1785 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: rfr:Rfer_2465 thiamine biosynthesis protein ThiS. (65 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (270 aa) |
| | Ajs_1783 | KEGG: rfr:Rfer_2467 thiamine-phosphate diphosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase. (309 aa) |
| | Ajs_1768 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: pol:Bpro_2316 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (188 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (554 aa) |
| | moaA | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (378 aa) |
| | mobA | Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (211 aa) |
| | Ajs_1747 | Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (452 aa) |
| | Ajs_1718 | KEGG: rfr:Rfer_2256 DNA-directed DNA polymerase. (331 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (217 aa) |
| | Ajs_1698 | PFAM: GCN5-related N-acetyltransferase; KEGG: xcb:XC_0671 ElaA protein. (154 aa) |
| | Ajs_1674 | PFAM: BolA family protein; KEGG: pol:Bpro_2584 BolA-like protein; Belongs to the BolA/IbaG family. (92 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (352 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | Ajs_1556 | SMART: Phage P4 alpha, zinc-binding domain protein; KEGG: dar:Daro_2291 hypothetical protein. (334 aa) |
| | Ajs_1506 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: mmr:Mmar10_0190 ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (299 aa) |
| | Ajs_1430 | KEGG: ecs:pO157p35 similar to SwissProt accession number P19593. (129 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | Ajs_1195 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa) |
| | Ajs_1188 | PFAM: molybdopterin binding domain; KEGG: pol:Bpro_1806 molybdopterin binding domain. (273 aa) |
| | Ajs_1182 | PFAM: phosphoribosyltransferase; KEGG: pol:Bpro_2596 phosphoribosyltransferase. (174 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (458 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | Ajs_1105 | KEGG: sma:SAV1685 hypothetical protein. (108 aa) |
| | Ajs_1102 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (189 aa) |
| | Ajs_1098 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (199 aa) |
| | Ajs_1097 | PFAM: Cobyrinic acid a,c-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: pol:Bpro_2785 cobyrinic acid a,c-diamide synthase. (452 aa) |
| | Ajs_1092 | KEGG: pol:Bpro_1208 oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (665 aa) |
| | Ajs_1051 | TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; KEGG: rfr:Rfer_2889 molybdopterin binding domain. (202 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (629 aa) |
| | Ajs_1008 | PFAM: beta-lactamase domain protein; KEGG: pol:Bpro_3172 beta-lactamase-like. (260 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa) |
| | Ajs_1001 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa) |
| | Ajs_0995 | KEGG: pol:Bpro_3186 hypothetical protein. (154 aa) |
| | queG | Putative iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (361 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | Ajs_0931 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (470 aa) |
| | Ajs_0921 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (414 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (298 aa) |
| | prs | Transcriptional regulator, Fis family; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa) |
| | Ajs_0879 | PFAM: GTP cyclohydrolase I; KEGG: pol:Bpro_0869 GTP cyclohydrolase I. (241 aa) |
| | Ajs_0876 | Dihydroneopterin triphosphate pyrophosphatase; PFAM: NUDIX hydrolase; KEGG: rfr:Rfer_1298 NUDIX hydrolase. (156 aa) |
| | Ajs_0863 | D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: pae:PA0316 D-3-phosphoglycerate dehydrogenase. (434 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (436 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (380 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | Ajs_0787 | KEGG: rfr:Rfer_2962 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (351 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (450 aa) |
| | cobS | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (270 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the t [...] (476 aa) |
| | Ajs_0540 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | Ajs_0538 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (292 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (258 aa) |
| | Ajs_0523 | PFAM: CBS domain containing protein; transporter-associated region; KEGG: rfr:Rfer_3698 CBS. (306 aa) |
| | Ajs_0508 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: rfr:Rfer_1087 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (190 aa) |
| | Ajs_0499 | KEGG: rfr:Rfer_0811 hypothetical protein. (64 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | Ajs_0408 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; KEGG: xcb:XC_2733 UDP-glucose dehydrogenase. (446 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (288 aa) |
| | queA | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (366 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: pol:Bpro_4451 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (266 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (519 aa) |
| | apaG | PFAM: ApaG domain protein; KEGG: pol:Bpro_4467 ApaG. (137 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa) |
| | Ajs_0354 | PFAM: CinA domain protein; KEGG: pol:Bpro_4476 CinA-like; Belongs to the CinA family. (179 aa) |
| | Ajs_0352 | PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); KEGG: bbr:BB1554 putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase. (433 aa) |
| | Ajs_0348 | RNA polymerase, sigma 54 subunit, RpoN/SigL; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (525 aa) |
| | Ajs_0311 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: reu:Reut_B3895 DNA ligase (ATP). (559 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa) |
| | Ajs_4160 | KEGG: pol:Bpro_0009 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease. (218 aa) |
| | Ajs_4145 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (184 aa) |
| | Ajs_4103 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_4286 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa) |
| | Ajs_4093 | KEGG: dar:Daro_3715 twin-arginine translocation pathway signal. (583 aa) |
| | Ajs_4080 | Conserved hypothetical protein; KEGG: gvi:glr1927 unknown protein. (397 aa) |
| | Ajs_4077 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: bbr:BB1167 riboflavin synthase alpha chain. (238 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: rfr:Rfer_3776 orotidine 5'-phosphate decarboxylase subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily. (306 aa) |
| | moaC-2 | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (166 aa) |
| | moaC | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | Ajs_4026 | KEGG: pol:Bpro_4662 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (459 aa) |
| | Ajs_3966 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3-methyltransferase; KEGG: pol:Bpro_4772 3-demethylubiquinone-9 3-methyltransferase. (142 aa) |
| | Ajs_3946 | PFAM: thiamineS protein; KEGG: rfr:Rfer_2848 thiamineS. (84 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purC | KEGG: pol:Bpro_4629 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (306 aa) |
| | Ajs_3915 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; KEGG: rfr:Rfer_0760 DNA polymerase III, delta subunit. (348 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (196 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1374 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1409 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (390 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (739 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (370 aa) |
| | Ajs_3852 | PFAM: Creatininase; KEGG: rfr:Rfer_3746 creatininase. (289 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (237 aa) |
| | Ajs_3804 | Flagellar protein export ATPase FliI; KEGG: rfr:Rfer_0553 ATPase FliI/YscN; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; SMART: AAA ATPase. (455 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (347 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (493 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (498 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (614 aa) |
| | Ajs_3653 | RNA polymerase, sigma subunit, ECF family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: bbr:BB1837 putative ECF-family RNA polymerase sigma factor. (243 aa) |
| | Ajs_3638 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | Ajs_3633 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (396 aa) |
| | Ajs_3632 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (972 aa) |
| | Ajs_3596 | KEGG: sat:SYN_02013 hypothetical cytosolic protein. (158 aa) |
| | purH | IMP cyclohydrolase; KEGG: rfr:Rfer_1582 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. (533 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pol:Bpro_1133 glutamate-1-semialdehyde-2,1-aminomutase. (434 aa) |
| | Ajs_3580 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pol:Bpro_1134 putative phosphomethylpyrimidine kinase. (314 aa) |
| | Ajs_3573 | PFAM: protein of unknown function DUF179; KEGG: pol:Bpro_1142 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (199 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: pol:Bpro_1145 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | Ajs_3569 | Dihydroorotase; PFAM: amidohydrolase; KEGG: rfr:Rfer_1381 amidohydrolase. (431 aa) |
| | Ajs_3539 | KEGG: pol:Bpro_1243 biotin synthesis protein BioC. (302 aa) |
| | Ajs_3528 | PFAM: cytochrome oxidase assembly; KEGG: rfr:Rfer_1688 cytochrome oxidase assembly. (396 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (306 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (321 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa) |
| | Ajs_3507 | [sulfur carrier protein ThiS] adenylyltransferase; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: rfr:Rfer_1307 UBA/ThiF-type NAD/FAD binding protein. (254 aa) |
| | Ajs_3498 | KEGG: pol:Bpro_0902 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (307 aa) |
| | Ajs_3497 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (374 aa) |
| | Ajs_3493 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (529 aa) |
| | Ajs_3469 | KEGG: pol:Bpro_0932 hypothetical protein. (193 aa) |
| | Ajs_3464 | PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: rfr:Rfer_3261 twin-arginine translocation pathway signal; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (989 aa) |
| | fdhD | Formate dehydrogenase, subunit FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (296 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (442 aa) |
| | Ajs_3398 | FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: pol:Bpro_3848 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (347 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (194 aa) |
| | cobD-2 | Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa) |
| | Ajs_3348 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: rfr:Rfer_1410 transcriptional coactivator/pterin dehydratase. (112 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (922 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (399 aa) |
| | queF | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (281 aa) |
| | Ajs_3274 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: pol:Bpro_3643 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (211 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (259 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | trpB-2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (422 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: rfr:Rfer_1789 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (247 aa) |
| | priB | Putative primosomal replication protein; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (96 aa) |
| | Ajs_3212 | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (472 aa) |
| | Ajs_3204 | TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: pol:Bpro_2192 molybdopterin-guanine dinucleotide biosynthesis protein B. (183 aa) |
| | Ajs_3203 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (414 aa) |
| | Ajs_3202 | TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein; KEGG: rfr:Rfer_1916 molybdopterin converting factor, subunit 1. (87 aa) |
| | Ajs_3199 | PFAM: molybdopterin biosynthesis MoaE; KEGG: rfr:Rfer_1917 molybdopterin biosynthesis MoaE. (158 aa) |
| | Ajs_3190 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (325 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (493 aa) |
| | Ajs_3177 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: dar:Daro_0141 nitroreductase. (253 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (352 aa) |
| | Ajs_3165 | KEGG: rme:Rmet_3997 hypothetical protein. (121 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (797 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (653 aa) |
| | Ajs_3116 | KEGG: pol:Bpro_3228 secreted hydrolase-like. (380 aa) |
| | Ajs_3076 | Serine palmitoyltransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; aminotransferase class-III; KEGG: neu:NE1655 aminotransferase class-I. (393 aa) |
| | Ajs_3069 | KEGG: ccr:CC1153 hypothetical protein. (268 aa) |
| | Ajs_3030 | PFAM: SMC domain protein; KEGG: cch:Cag_0257 ATPase. (406 aa) |
| | Ajs_3029 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: eba:ebA5887 probable NAD dependent epimerase/dehydratase, possibly involved in polysaccharide biosynthesis. (383 aa) |
| | purM | KEGG: pol:Bpro_3566 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (349 aa) |
| | Ajs_2990 | KEGG: bpa:BPP3629 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (167 aa) |
| | Ajs_2963 | KEGG: cvi:CV3228 hypothetical protein. (162 aa) |
| | Ajs_2893 | PFAM: HemY domain protein; KEGG: pol:Bpro_3661 putative porphyrin biosynthesis related protein. (427 aa) |
| | Ajs_2892 | PFAM: protein of unknown function DUF513, hemX; KEGG: rfr:Rfer_1717 protein of unknown function DUF513, HemX. (358 aa) |
| | Ajs_2891 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (272 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (320 aa) |
| | Ajs_2843 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rfr:Rfer_2883 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (269 aa) |
| | Ajs_2842 | PFAM: glycosyl transferase, family 3; KEGG: pol:Bpro_3280 glycosyl transferase, family 3. (309 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (177 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribB-2 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (373 aa) |
| | Ajs_2746 | RNA polymerase, sigma subunit, ECF family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: bps:BPSL1130 putative sigma factor. (295 aa) |
| | Ajs_2745 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (222 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (239 aa) |
| | Ajs_2739 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa) |
| | Ajs_2689 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: pol:Bpro_1193 ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (299 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (381 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (494 aa) |
| | Ajs_2554 | RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: rfr:Rfer_2548 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (171 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (538 aa) |
| | Ajs_2541 | Plasmid and phage iteron-binding protein; PFAM: replication C family protein; KEGG: pau:PA14_15400 putative replication protein, RepC. (289 aa) |
| | Ajs_2523 | Bifunctional non-homologous end joining protein LigD; PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: tbd:Tbd_2247 DNA ligase, ATP-dependent, putative. (837 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (398 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (371 aa) |
| | Ajs_2415 | RNA polymerase, sigma subunit, ECF family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: rfr:Rfer_4146 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (222 aa) |
| | Ajs_2410 | PFAM: protein of unknown function DUF336; KEGG: rfr:Rfer_2775 protein of unknown function DUF336. (135 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: rfr:Rfer_2004 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (390 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: pol:Bpro_2678 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1053 aa) |
| | Ajs_2382 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (420 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (679 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (262 aa) |
| | Ajs_2265 | PFAM: 3-demethylubiquinone-9 3-methyltransferase; KEGG: nha:Nham_3665 3-demethylubiquinone-9 3-methyltransferase. (150 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (223 aa) |
| | Ajs_2219 | PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein; KEGG: ppu:PP_3868 group II intron-encoding maturase. (473 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (237 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (351 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (217 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (350 aa) |
| | Ajs_2025 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: nfa:nfa6270 hypothetical protein. (193 aa) |
| | Ajs_2016 | propionyl-CoA synthetase; TIGRFAM: propionate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: rfr:Rfer_2322 propionate--CoA ligase. (631 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1064 aa) |
| | Ajs_1926 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: pol:Bpro_2956 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (335 aa) |
| | Ajs_1922 | PFAM: DNA polymerase III chi subunit, HolC; KEGG: rfr:Rfer_2117 DNA polymerase III chi subunit, HolC. (146 aa) |
| | Ajs_1918 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: rfr:Rfer_2113 cobalamin (vitamin B12) biosynthesis CbiX protein. (127 aa) |
| | Ajs_1913 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: net:Neut_1002 uroporphyrin-III C-methyltransferase. (282 aa) |
| | Ajs_1909 | KEGG: tbd:Tbd_0074 possible transcriptional regulator, AsnC family. (348 aa) |
| | Ajs_1908 | Transcriptional regulator, AsnC family; KEGG: eba:ebA880 NirG protein precursor. (160 aa) |
| | Ajs_1907 | Transcriptional regulator, AsnC family; KEGG: dar:Daro_3267 regulatory proteins, AsnC/Lrp. (160 aa) |
| | Ajs_1906 | PFAM: Radical SAM domain protein; KEGG: tbd:Tbd_0071 elongator protein 3/MiaB/NifB. (406 aa) |
| | hemF | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (334 aa) |
