STRINGSTRING
Acid_0058 Acid_0058 aroK aroK Acid_0987 Acid_0987 Acid_1065 Acid_1065 katG katG Acid_1182 Acid_1182 Acid_1183 Acid_1183 Acid_1323 Acid_1323 Acid_2030 Acid_2030 aroC aroC Acid_3092 Acid_3092 Acid_3339 Acid_3339 trpD trpD aroE aroE Acid_3849 Acid_3849 hisF hisF hisH hisH hisB hisB Acid_3853 Acid_3853 hisC hisC hisD hisD hisG hisG hisI hisI Acid_3954 Acid_3954 Acid_4098 Acid_4098 hisC-2 hisC-2 Acid_4167 Acid_4167 Acid_4459 Acid_4459 Acid_4482 Acid_4482 Acid_5081 Acid_5081 Acid_5239 Acid_5239 Acid_5467 Acid_5467 Acid_6097 Acid_6097 Acid_6369 Acid_6369 Acid_6516 Acid_6516 Acid_6517 Acid_6517 hmgA hmgA Acid_7054 Acid_7054 aroD aroD Acid_7274 Acid_7274 aroA aroA aroB aroB Acid_7884 Acid_7884 Acid_7885 Acid_7885 Acid_7886 Acid_7886 trpA trpA trpB-2 trpB-2 trpF trpF trpC trpC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Acid_0058Aminotransferase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: dps:DP2938 probable aspartate aminotransferase. (402 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa)
Acid_0987Anthranilate synthase, component II / anthranilate synthase, component I; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: ava:Ava_4890 glutamine amidotransferase of anthranilate synthase. (723 aa)
Acid_10653-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: aba:Acid345_3110 phospho-2-dehydro-3-deoxyheptonate aldolase. (345 aa)
katGCatalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (743 aa)
Acid_1182PFAM: Pyridoxal-dependent decarboxylase; KEGG: tyrosine decarboxylase, putative. (470 aa)
Acid_1183PFAM: Pyrrolo-quinoline quinone; KEGG: gcd-1; glucose dehydrogenase. (706 aa)
Acid_1323KEGG: bur:Bcep18194_B2301 hypothetical protein. (200 aa)
Acid_2030PFAM: aminotransferase, class I and II; KEGG: ccr:CC1071 histidinol-phosphate aminotransferase, putative. (372 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa)
Acid_3092PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein; KEGG: rso:RSp1398 shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (286 aa)
Acid_3339PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_3031 aminotransferase class I and II. (381 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (285 aa)
Acid_38491-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis; KEGG: aba:Acid345_3688 histidine biosynthesis. (227 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (186 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aba:Acid345_3685 imidazoleglycerol-phosphate dehydratase. (195 aa)
Acid_3853TIGRFAM: HAD superfamily (subfamily IA) hydrolase, TIGR01548; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sru:SRU_2236 HAD superfamily (subfamily IA) hydrolase, TIGR01548. (220 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: aba:Acid345_3684 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (423 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa)
Acid_3954PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_3031 aminotransferase class I and II. (388 aa)
Acid_4098Phenylalanine 4-hydroxylase; PFAM: aromatic amino acid hydroxylase; KEGG: bur:Bcep18194_A3259 phenylalanine-4-hydroxylase, monomeric form. (306 aa)
hisC-2Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: pfo:Pfl_4075 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa)
Acid_4167KEGG: sru:SRU_1370 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (375 aa)
Acid_4459PFAM: aminotransferase, class I and II; KEGG: ccr:CC1071 histidinol-phosphate aminotransferase, putative. (383 aa)
Acid_4482KEGG: bur:Bcep18194_B2301 hypothetical protein. (184 aa)
Acid_5081PFAM: tyrosinase. (340 aa)
Acid_5239PFAM: transcriptional coactivator/pterin dehydratase; KEGG: cyb:CYB_2873 putative pterin-4A-carbinolamine dehydratase. (95 aa)
Acid_54673-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase, class II; KEGG: xcb:XC_3313 family II 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (471 aa)
Acid_6097KEGG: bur:Bcep18194_B2301 hypothetical protein. (202 aa)
Acid_6369Tryptophanase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: aba:Acid345_3931 tryptophanase. (448 aa)
Acid_6516Fumarylacetoacetate hydrolase; KEGG: aba:Acid345_2007 fumarylacetoacetase; TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase. (402 aa)
Acid_6517KEGG: aba:Acid345_2006 hypothetical protein. (262 aa)
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (426 aa)
Acid_7054PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: aba:Acid345_2043 prephenate dehydratase. (284 aa)
aroDShikimate dehydrogenase / 3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family. (509 aa)
Acid_7274PFAM: aminotransferase, class I and II; KEGG: aba:Acid345_0568 aminotransferase, class I and II. (397 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (357 aa)
Acid_7884PFAM: Prephenate dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: aba:Acid345_1162 prephenate dehydrogenase. (281 aa)
Acid_78853-deoxy-D-arabinoheptulosonate-7-phosphate synthase; KEGG: tte:TTE1013 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (337 aa)
Acid_7886PFAM: Chorismate mutase; KEGG: gme:Gmet_1955 chorismate mutase. (100 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
trpB-2Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: tbd:Tbd_1915 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: aba:Acid345_1156 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (262 aa)
Your Current Organism:
Solibacter usitatus
NCBI taxonomy Id: 234267
Other names: Acidobacteriaceae bacterium Ellin6076, Acidobacterium sp. Ellin6076, C. Solibacter usitatus Ellin6076, Candidatus Solibacter usitatus Ellin6076, Solibacter usitatus Ellin6076, bacterium Ellin6076
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