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aroE aroE argJ argJ argB argB serB serB argG argG argF argF argD argD AFE_0407 AFE_0407 pabB pabB argA argA AFE_0665 AFE_0665 AFE_0666 AFE_0666 ispZ ispZ AFE_0668 AFE_0668 aroB aroB aroK aroK AFE_0756 AFE_0756 serC serC serA serA pheA pheA hisC-2 hisC-2 AFE_0899 AFE_0899 tyrA tyrA aroA aroA hisZ hisZ aroC aroC aspC aspC trpA trpA trpB trpB trpF trpF asd asd dapA dapA dapB dapB AFE_2671 AFE_2671 AFE_3031 AFE_3031 AFE_3032 AFE_3032 AFE_3033 AFE_3033 surA surA AFE_3037 AFE_3037 AFE_3038 AFE_3038 murA murA hisG hisG hisD hisD hisC-1 hisC-1 hisB hisB hisH hisH hisA hisA hisF hisF hisIE hisIE tatA tatA tatB tatB tatC tatC argC argC tatA-2 tatA-2 trpC trpC trpD trpD pabA pabA trpE trpE argH argH lysA lysA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (298 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa)
serBPhosphoserine phosphatase; Identified by similarity to SP:P06862; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (327 aa)
argGArgininosuccinate synthase; Identified by similarity to SP:Q9HY84; match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (311 aa)
argDAcetylornithine aminotransferase; Identified by similarity to SP:P54752; match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa)
AFE_0407Aspartate kinase, monofunctional class; Identified by similarity to SP:P41403; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00656; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (408 aa)
pabBPara-aminobenzoate synthase, component I; Identified by similarity to SP:P05041; match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553. (462 aa)
argAN-acetylglutamate synthase; Identified by similarity to SP:P08205; match to protein family HMM PF00583; match to protein family HMM PF00696; match to protein family HMM TIGR01890; Belongs to the acetyltransferase family. ArgA subfamily. (435 aa)
AFE_0665Identified by match to protein family HMM PF01722; Belongs to the BolA/IbaG family. (103 aa)
AFE_0666YCII-related domain protein; Identified by match to protein family HMM PF03795. (109 aa)
ispZIntracellular septation protein A; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. (185 aa)
AFE_0668Conserved hypothetical protein; Identified by similarity to GB:CAD86126.1; match to protein family HMM PF05673. (287 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (364 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa)
AFE_0756HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by similarity to GB:AAN70712.1; match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. (230 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
serAD-3-phosphoglycerate dehydrogenase; Identified by similarity to SP:P35136; match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
pheAChorismate mutase/prephenate dehydratase; Identified by similarity to SP:P27603; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807. (358 aa)
hisC-2Histidinol-phosphate aminotransferase; Identified by similarity to SP:P17731; match to protein family HMM PF00155; match to protein family HMM PF00266; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
AFE_0899Phospho-2-dehydro-3-deoxyheptonate aldolase; Identified by match to protein family HMM PF00793; match to protein family HMM TIGR01361. (338 aa)
tyrAPrephenate dehydrogenase; Identified by similarity to SP:P20692; match to protein family HMM PF02153. (301 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (400 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
aspCAspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. (393 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa)
trpFN-(5'phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:Q56320; match to protein family HMM PF00697; Belongs to the TrpF family. (205 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (276 aa)
AFE_2671Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; Identified by similarity to SP:P39912; match to protein family HMM PF00793. (372 aa)
AFE_3031Hypothetical protein; Identified by glimmer; putative. (144 aa)
AFE_3032Identified by match to protein family HMM PF00483. (229 aa)
AFE_3033Phosphotransferase, putative; Identified by match to protein family HMM PF01636. (342 aa)
surASurvival protein SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (436 aa)
AFE_3037Identified by match to protein family HMM PF01722; Belongs to the BolA/IbaG family. (110 aa)
AFE_3038Identified by match to protein family HMM PF00462; match to protein family HMM TIGR00365; Belongs to the glutaredoxin family. Monothiol subfamily. (110 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa)
hisC-1Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
hisBImidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. (199 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (223 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:O35006; match to protein family HMM PF00977; match to protein family HMM TIGR00007. (242 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisIEphosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; match to protein family HMM TIGR03456; In the N-terminal section; belongs to the PRA-CH family. (230 aa)
tatATwin-arginine translocation protein, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (72 aa)
tatBTwin-arginine translocation protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (122 aa)
tatCSec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (268 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa)
tatA-2Twin-arginine translocation protein, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (82 aa)
trpCIndole-3-glycerol phosphate synthase; Identified by similarity to SP:P20577; match to protein family HMM PF00218; Belongs to the TrpC family. (263 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
pabAPara-aminobenzoate synthase glutamine amidotransferase component II; Identified by similarity to PIR:A01122; match to protein family HMM PF00117; match to protein family HMM TIGR00566. (190 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (505 aa)
argHArgininosuccinate lyase; Identified by similarity to SP:O34858; match to protein family HMM PF00206; match to protein family HMM TIGR00838. (462 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa)
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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