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| | djlA | DnaJ-like protein DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. (276 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (425 aa) |
| | MCA0023 | Putative membrane protein; Identified by similarity to OMNI:NTL03PA00341; match to protein family HMM PF01925. (294 aa) |
| | slyD | Peptidyl-prolyl cis-trans isomerase, FKBP-type; Identified by similarity to SP:P30856; match to protein family HMM PF00254. (160 aa) |
| | mreB | Rod shape-determining protein MreB; Identified by similarity to SP:P13519; match to protein family HMM PF06723; match to protein family HMM TIGR00904. (347 aa) |
| | mreC | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (300 aa) |
| | mreD | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (163 aa) |
| | mrdA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (611 aa) |
| | rodA | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (377 aa) |
| | MCA0105 | D-alanyl-D-alanine carboxypeptidase; Identified by similarity to SP:P08506; match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family. (392 aa) |
| | MCA0107 | Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family. (87 aa) |
| | mgtE | Magnesium transporter; Acts as a magnesium transporter. (481 aa) |
| | lipB | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (207 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | MCA0111 | Conserved hypothetical protein; Identified by similarity to OMNI:MT0787. (200 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (454 aa) |
| | apaH | Bis(5'-nucleosyl)-tetraphosphatase, symmetrical; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (278 aa) |
| | MCA0170 | Fatty acid desaturase family protein; Identified by similarity to OMNI:NTL03PA00287; match to protein family HMM PF00487. (446 aa) |
| | MCA0171 | Putative lipoprotein; Identified by similarity to GP:17427325. (172 aa) |
| | MCA0172 | Mce family protein; Identified by similarity to GP:17427324; match to protein family HMM PF02470. (304 aa) |
| | MCA0173 | ABC transporter, ATP-binding protein; Identified by similarity to OMNI:NTL01SM01832; match to protein family HMM PF00005. (256 aa) |
| | MCA0174 | Putative ABC transporter, permease protein; Gene cluster is evidence for assignment as ABC transporter subunit; identified by match to protein family HMM PF02405. (406 aa) |
| | MCA0175 | Hypothetical protein; Identified by Glimmer2; putative. (51 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (195 aa) |
| | MCA0240 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00760; match to protein family HMM PF01571; Belongs to the GcvT family. (356 aa) |
| | apaG | apaG protein; Identified by similarity to SP:Q56017; match to protein family HMM PF04379. (126 aa) |
| | MCA0288 | Transglycosylase SLT domain protein; Identified by match to protein family HMM PF01464. (410 aa) |
| | mrcA | Penicillin-binding protein 1A; Identified by similarity to SP:P02918; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074. (830 aa) |
| | xerD | Tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (309 aa) |
| | lpxA-1 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Identified by similarity to SP:P10440; match to protein family HMM PF00132; match to protein family HMM TIGR01852. (260 aa) |
| | MCA0398 | Putative oxidoreductase, Gfo/Idh/MocA family; Identified by similarity to GP:1001423; match to protein family HMM PF01408; match to protein family HMM PF02894. (319 aa) |
| | MCA0399 | Aminotransferase, DegT/DnrJ/EryC1/StrS family; Identified by match to protein family HMM PF01041; Belongs to the DegT/DnrJ/EryC1 family. (364 aa) |
| | lpxB | Lipid A disaccharide synthase (lpxB); Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (384 aa) |
| | MCA0401 | Putative transcription elongation factor; Identified by similarity to OMNI:CC2202; match to protein family HMM PF01272. (166 aa) |
| | MCA0402 | Conserved domain protein; Identified by similarity to OMNI:DR2490; match to protein family HMM PF01863. (245 aa) |
| | MCA0403 | Putative suppressor for copper-sensitivity D; Identified by similarity to GP:2327006. (162 aa) |
| | MCA0435 | Conserved hypothetical protein; Identified by similarity to OMNI:VC1548. (223 aa) |
| | MCA0436 | MotA/TolQ/ExbB proton channel family protein; Identified by match to protein family HMM PF01618. (403 aa) |
| | exbB2 | MotA/TolQ/ExbB proton channel family domain protein; Identified by match to protein family HMM PF01618. (165 aa) |
| | MCA0438 | Biopolymer transport protein, ExbD/TolR family; Identified by similarity to SP:Q05606; match to protein family HMM PF02472. (137 aa) |
| | MCA0439 | TonB domain protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (215 aa) |
| | MCA0440 | Putative TonB-dependent receptor; Identified by similarity to OMNI:NTL03PA03268; match to protein family HMM PF00593; match to protein family HMM PF07715. (775 aa) |
| | MCA0441 | TonB domain protein; Identified by match to protein family HMM PF03544; match to protein family HMM TIGR01352. (248 aa) |
| | MCA0442 | MotA/TolQ/ExbB proton channel family protein; Identified by similarity to OMNI:NTL03PA00199; match to protein family HMM PF01618. (218 aa) |
| | MCA0443 | Biopolymer transport protein, ExbD/TolR family; Identified by similarity to SP:P05829; match to protein family HMM PF02472. (136 aa) |
| | MCA0471 | Identified by match to protein family HMM PF02366. (583 aa) |
| | dsbC | Thiol:disulfide interchange protein DsbC; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (210 aa) |
| | MCA0598 | Aminotransferase; Identified by similarity to SP:P77434; match to protein family HMM PF00155. (358 aa) |
| | MCA0599 | Identified by similarity to GP:4545244; match to protein family HMM PF00483. (232 aa) |
| | MCA0600 | Conserved hypothetical protein; Identified by similarity to GP:4545243. (341 aa) |
| | lptD | Putative organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (1091 aa) |
| | surA | Peptidyl-prolyl cis-trans isomerase SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (454 aa) |
| | pdxA | Pyridoxal phosphate biosynthetic protein PdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (330 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (257 aa) |
| | MCA0630 | Hypothetical protein; Identified by Glimmer2; putative. (169 aa) |
| | MCA0631 | MotA/TolQ/ExbB proton channel family domain protein; Identified by match to protein family HMM PF01618. (204 aa) |
| | MCA0632 | Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472. (141 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (336 aa) |
| | MCA0634 | Conserved hypothetical protein; Identified by similarity to OMNI:VC1876; match to protein family HMM PF03966; Belongs to the UPF0434 family. (70 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (257 aa) |
| | MCA0636 | Conserved hypothetical protein; Identified by similarity to SP:P76631. (142 aa) |
| | MCA0668 | TonB domain protein; Identified by match to protein family HMM PF03544; match to protein family HMM TIGR01352. (193 aa) |
| | MCA0669 | MotA/TolQ/ExbB proton channel family protein; Identified by similarity to OMNI:NTL03PA00199; match to protein family HMM PF01618. (218 aa) |
| | MCA0670 | Biopolymer transport protein, ExbD/TolR family; Identified by similarity to OMNI:NTL03PA00200; match to protein family HMM PF02472. (136 aa) |
| | MCA0672 | Putative lipoprotein. (235 aa) |
| | hpnR | Radical SAM domain/B12 binding domain protein; Required for methylation of hopanoids at the C-3 position. (515 aa) |
| | MCA0739 | Conserved hypothetical protein; Displays ATPase and GTPase activities. (295 aa) |
| | yfiA | Ribosomal subunit interface protein; Identified by similarity to GP:6141572; match to protein family HMM PF02482; match to protein family HMM TIGR00741. (98 aa) |
| | MCA0742 | ABC transporter, ATP-binding family protein; Identified by similarity to SP:P45073; match to protein family HMM PF00005. (241 aa) |
| | lptA | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (177 aa) |
| | MCA0744 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA04460; match to protein family HMM PF06835. (174 aa) |
| | MCA0745 | Phosphatase, YrbI family; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (191 aa) |
| | MCA0746 | Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393. (330 aa) |
| | rlpA | Putative rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (135 aa) |
| | erpA2 | HesB/YadR/YfhF family protein; Required for insertion of 4Fe-4S clusters for at least IspG. (130 aa) |
| | MCA0806 | Conserved hypothetical protein; Identified by similarity to OMNI:NMB1963. (216 aa) |
| | comL | Competence lipoprotein ComL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (286 aa) |
| | tolQ | tolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (225 aa) |
| | tolR | tolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (146 aa) |
| | MCA1228 | Putative TolA protein; Identified by similarity to SP:P50600; match to protein family HMM PF06519; match to protein family HMM TIGR01352. (467 aa) |
| | tolB | tolB protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (424 aa) |
| | pal | OmpA family protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (215 aa) |
| | cpoB | Conserved hypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (285 aa) |
| | queE | Radical activating enzyme family protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (223 aa) |
| | MCA1275 | Putative membrane protein; Identified by similarity to OMNI:NTL02ML6584; match to protein family HMM PF01594. (354 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (271 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (449 aa) |
| | lpxH | Putative UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (241 aa) |
| | MCA1337 | Putative membrane protein; Identified by similarity to OMNI:NTL03PA03747; match to protein family HMM PF01578. (273 aa) |
| | MCA1363 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA03804. (294 aa) |
| | MCA1403 | Membrane-bound lytic murein transglycosylase; Identified by similarity to SP:P23931; match to protein family HMM PF01464. (401 aa) |
| | rlpB | Rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. (172 aa) |
| | MCA1454 | Identified by match to protein family HMM PF01656. (258 aa) |
| | MCA1576 | Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073. (713 aa) |
| | MCA1672 | Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (759 aa) |
| | MCA1693 | Conserved domain protein. (201 aa) |
| | MCA1695 | Putative cell division protein FtsK; Identified by similarity to SP:P46889; match to protein family HMM PF01580. (844 aa) |
| | rfaE | Lipopolysaccharide biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (473 aa) |
| | lolA | Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (208 aa) |
| | MCA1957 | Putative TonB-dependent receptor; Identified by similarity to OMNI:CC1750; match to protein family HMM PF00593; match to protein family HMM PF07715. (638 aa) |
| | sspB | Identified by similarity to SP:P25663; match to protein family HMM PF04386. (130 aa) |
| | sspA | Identified by match to protein family HMM PF00043; match to protein family HMM PF02798. (217 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | MCA1966 | STAS domain protein; Identified by match to protein family HMM PF01740. (120 aa) |
| | MCA1967 | Conserved hypothetical protein; Identified by similarity to GP:4336800; match to protein family HMM PF02470. (166 aa) |
| | MCA1968 | Conserved hypothetical protein TIGR00056; Identified by similarity to OMNI:VC2519; match to protein family HMM PF02405; match to protein family HMM TIGR00056. (263 aa) |
| | MCA1969 | ABC transporter, ATP-binding family protein; Identified by similarity to SP:P45393; match to protein family HMM PF00005. (275 aa) |
| | MCA2008 | Transglycosylase SLT domain protein; Identified by similarity to GP:17427990; match to protein family HMM PF01464. (214 aa) |
| | MCA2028 | Putative membrane-bound lytic murein transglycosylase; Identified by similarity to SP:P23931; match to protein family HMM PF01464; match to protein family HMM PF01476. (562 aa) |
| | MCA2029 | Conserved domain protein. (246 aa) |
| | kdtA | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa) |
| | MCA2051 | Hydrolase, HAD-superfamily, subfamily IIIA; Identified by match to protein family HMM TIGR01656; match to protein family HMM TIGR01662. (179 aa) |
| | vacJ | vacJ lipoprotein; Identified by similarity to SP:P76506; match to protein family HMM PF04333. (284 aa) |
| | MCA2100 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA03828; match to protein family HMM PF03739. (339 aa) |
| | MCA2101 | Putative membrane protein; Identified by similarity to SP:P39341; match to protein family HMM PF03739. (356 aa) |
| | MCA2138 | Conserved hypothetical protein; Identified by similarity to SP:Q46868; match to protein family HMM PF04380. (83 aa) |
| | mviN | Membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (513 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (309 aa) |
| | lspA | Signal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (158 aa) |
| | MCA2255 | Hypothetical protein; Identified by Glimmer2; putative. (115 aa) |
| | MCA2337 | Putative TonB-dependent receptor; Identified by similarity to GP:17429800; match to protein family HMM TIGR01352. (279 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (304 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (382 aa) |
| | ftsA | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (411 aa) |
| | ftsQ | Putative cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (273 aa) |
| | ddL | D-alanine--D-alanine ligase; Cell wall formation. (309 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (472 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (354 aa) |
| | ftsW | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (398 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (459 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (479 aa) |
| | ftsI | Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (575 aa) |
| | ftsL | Putative cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (85 aa) |
| | rsmH | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (301 aa) |
| | mraZ | mraZ protein; Identified by match to protein family HMM PF02381; match to protein family HMM TIGR00242; Belongs to the MraZ family. (152 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (673 aa) |
| | MCA2439 | Putative cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. (222 aa) |
| | queF | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (129 aa) |
| | MCA2442 | MOSC domain protein; Identified by similarity to OMNI:NTL01BH0617; match to protein family HMM PF03473. (211 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (193 aa) |
| | lpxA-2 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (264 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | MCA2446 | Putative outer membrane protein OmpH; Identified by similarity to SP:P31519; match to protein family HMM PF03938; Belongs to the skp family. (168 aa) |
| | bamA | Outer membrane protein, OMP85 family; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (796 aa) |
| | kdsA | 3-deoxy-8-phosphooctulonate synthase; Identified by similarity to OMNI:NTL01XF01290; match to protein family HMM PF00793; match to protein family HMM TIGR01362; Belongs to the KdsA family. (252 aa) |
| | ftsB | Septum formation initiator family protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (122 aa) |
| | MCA2528 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01XF01262. (157 aa) |
| | lpxD | UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (354 aa) |
| | dsbA | Thiol:disulfide interchange protein DsbA; Identified by similarity to SP:P32557; match to protein family HMM PF01323. (216 aa) |
| | smpA | Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (161 aa) |
| | MCA2624 | Lipoprotein ABC transporter, permease protein LolE; Identified by similarity to SP:P75958; match to protein family HMM PF02687; match to protein family HMM TIGR02212. (415 aa) |
| | lolD | Lipoprotein ABC transporter, ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (224 aa) |
| | pepP | Xaa-pro aminopeptidase; Identified by similarity to SP:P15034; match to protein family HMM PF00557; match to protein family HMM PF05195; Belongs to the peptidase M24B family. (436 aa) |
| | MCA2771 | Conserved hypothetical protein; Identified by similarity to SP:Q9HTW5; match to protein family HMM TIGR02292; Belongs to the UPF0149 family. (178 aa) |
| | MCA2772 | Conserved hypothetical protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (97 aa) |
| | MCA2792 | Conserved hypothetical protein; Identified by similarity to OMNI:CC3693; match to protein family HMM PF05494. (217 aa) |
| | smg | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01XF00924; match to protein family HMM PF04361; Belongs to the Smg family. (155 aa) |
| | dsbB | Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (164 aa) |
| | MCA3064 | Hypothetical protein; Identified by Glimmer2; putative. (112 aa) |
| | minC | Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (240 aa) |
| | minD | Septum site-determining protein MinD; Identified by similarity to SP:P18197; match to protein family HMM PF01656; match to protein family HMM TIGR01968. (269 aa) |
| | minE | Cell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (93 aa) |
| | MCA3069 | Conserved hypothetical protein. (71 aa) |
| | MCA3090 | Conserved domain protein; Identified by similarity to OMNI:NTL03PA05053; match to protein family HMM PF05036. (213 aa) |
